ID   A0A1I8IA72_9PLAT        Unreviewed;      1177 AA.
AC   A0A1I8IA72;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Amiloride-sensitive sodium channel {ECO:0000313|WBParaSite:maker-uti_cns_0010860-snap-gene-0.4-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0010860-snap-gene-0.4-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0010860-snap-gene-0.4-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR   AlphaFoldDB; A0A1I8IA72; -.
DR   WBParaSite; maker-uti_cns_0010860-snap-gene-0.4-mRNA-1; maker-uti_cns_0010860-snap-gene-0.4-mRNA-1; maker-uti_cns_0010860-snap-gene-0.4.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        840..860
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          242..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          516..558
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          645..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          708..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..558
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..782
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..814
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1177 AA;  129150 MW;  CA78F62C66920D27 CRC64;
     YDVVQLPVHT IRPDAAFPSV TICNQNPISL RGHRLLRQRG WPGPRDFFRL AWKRRTQMHP
     SNGGNLSKSD AGNLRNYISG LLSFNAYFAN LPKGSDPHEL GHSKEDLIRS CYLLVQSSTS
     GKEPPVNSPR CDHLGWWRQV YDQNRLNCYT YMADRQHEND AVVEMELRLF LGHELNFDCS
     DCVLMDVSSQ TRGATVVLHP NGTYPDVQRD GFTVYPGTLT EVTFATLNWT RLGPPYGNCD
     PNPPSYLNIA NTEGTDSSSA QNSNQNQQQQ QQRQEHRNHQ KLFAYTSRAC HKLSLLSRIQ
     SDCNCSFAFL LPHAPISSVQ PTVCESLDAD NTINFSSSGL LRAINRTRCG MLGAFANFDS
     GCREPCSHFS YQIATTQSQW PRESMLANIF KYELANDKDL DLNSNSSAEL SSQEWQLAEM
     YEQVRQLIPN STANASSLLK QLGLISDSFV TLKVTRKDFS VTQIAEKPVQ TLASTFSQVG
     GLLSMWIGLT FVWLVELLDL GLQLLQLLCR RLSTDGHRKS SSTESKSVRQ SRLSPGQLDS
     ADNGTAPSTF PGRAGNLTKA TTTTNSALTA LAAANLSQQN LFSGHGAHNL EYAVDVNRLG
     LPDAPVHDAG ANGSRLRYVT LGSTKLNETV TVCYWKKKTR PADASSAASV AVARPREPTG
     RPRQQRQFSK NCPSLVPIPV AAQEQRPALV ASEPPAQTLR HLHRLNQAAS THMRRLSEPA
     PTFPSSTSSS TSSSSSPASS SHMSQRTMTL TTTASLTSVG PFEGGNWRSR SSGGSRRRGR
     RSASASGSWR VAAGRSRSRR SATSRRLRRR ARGQHPDPVK RDPTAVVVVE LDVHQLPTGL
     GLLFIVVNFF GFIIGFRIVV ALMRTDGARV QGGQARRPIG ADSAAGWQLR HLAWHSSSSL
     VKYWCRLLGD PFKDTRYTSG GCTSFSTPEY HRPPAKASMC TEDANGLKAS PPSLPLLPAE
     AEAATTASLR CLDLLAWLCR PRLEDFSRLR LCCIRRHRAS ICATSCSQSL ASGMSLDPAL
     KSTRLTGLVS YLQPRLSTEL TAMSAASRHC CWSSSNCSRS TCCSKPATAH RMSHWRWPLL
     ADFASTTIAD VDEVAASIDD EAEAAESPLN LSVSRSGSIQ MMLHRLSLLP WKQASRPACL
     HVGAVHSQNA VTDPDAISFA EHDATARVLA ITIFNLI
//