ID A0A1I8IAM0_9PLAT Unreviewed; 1613 AA.
AC A0A1I8IAM0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 2 {ECO:0000313|WBParaSite:maker-uti_cns_0011293-snap-gene-0.2-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0011293-snap-gene-0.2-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0011293-snap-gene-0.2-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR WBParaSite; maker-uti_cns_0011293-snap-gene-0.2-mRNA-1; maker-uti_cns_0011293-snap-gene-0.2-mRNA-1; maker-uti_cns_0011293-snap-gene-0.2.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF355; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 24..233
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 336..522
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1360..1593
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 85..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 258..298
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 101..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1613 AA; 178067 MW; FA59DE7276B68C47 CRC64;
MQKAIRVNDS QLLLLSGKAR EPGCATLSGN LYKRSLDTGK WQLRYFVLYQ NLLFYYDSDR
CDRPSGVALL EGSYCDKQTA LKLPERGGRG RQQQWTVRRR AGGRTDGDLA VDGADRKLRG
AQEERRHPSN AAASSAAGRD WGGPGSHGFN RVVPLPLAFP LPNPNIPFIL FAHRTEERKL
LRGYPPRERG CKRRARHAFN IFYKKDGQRH YDLRAETDAD CTAWLQPAAR HQGGARTEEF
APAADHGERE RLSKWHYVKQ TEELMAEVAQ LRKEVRELKE LQHKETALSR TNSEETEELR
KIKKVQSFFR GWLCRRRWKN IVEEYIRSEH AEHMRKRNNI VFGLVECEEE YVQQITILVS
CFLRPCRMAA SAKKPIITHE DVNSIFLNAE TLLFLHQIFL QGLNSKMDNW PTLQLGDLFD
MLLPMLSIYQ EYVRNHHYSL QVLAEYKQKA EFTGLLKRYE EKSLCEGRSM ETFLTYPMHQ
IPRYIVTLHE LLAHTPHDHV DRQQLEFAKS KLEDLSHAMH DEVSETENIR KNLAIERMIV
EGCDILLDVN QIFVRQGCLT QLPIGEKGRN TRPRIGSFSS TFNKDSRKEA VRQVFLFTNH
LILTTRASNG RLHLVKLTVE AGQQRLEQRA ADYSGLDFRL IVDFKSGPPV TITLVANSAQ
EKAAWCSDIN QCIEQIHYSD LLNSSLAETS LVSMPHTIRS DPKLFRDDVD IKFSRTLNSC
KVPQIRHATV ERLLDRLTDL RFLSIDFLNT FLLTYRVFTE PKTVISALKR ILTNPEYGNL
DPRPSICLQS SLESETGGGG GGSGGGGFLH VKPELDKLRR ISTGMMRLEA SQASAAAGAG
SAGPSGVGGG GDGGGASSSS GADGGGGVDP YGATHRTGSL DAGACERLAA HHRSAPTYTV
EGGRLQPPPA GPPSYGGATS GDPAADPPEI LRELSEITAA AKAAARAAKA VRSSPQPALM
QTQPAESPPR MPLARMAPIA SCETMLDEAT RSSLSDSSGS EAAAEIATAT AAAEAKTVGV
RRVRISGVTE TEVCDSSSPP SPQRQPPASP TIRRPTKFDV PSMRIPESQL LDHTSLSPGG
SPQPKHRLAS PCHSPGHVRR ATSPTVAERI AGAAASIASR LGGATSPISH SASSPTVNQS
PFRGSVASGS GGPMKRTSCA ADSTAGDLSA GAPSSGRPSL ARSSDVDSPP CRAKAGAVVT
SSRASKRRSS NTAAALAFAA ATAGASTLPK SSVRIAVQEQ ESEVQMPQLM QHRPSESSSI
MVKRLSIICT AATMRVLNVV RHWVYKFGED IESDPTLRAD MIDLLEDLVC NQNLFPPDHK
AALQILLKLR EEPLAEADND LERILTPAWQ PSFESFETLS ALDIAEQITL IDHKLFRALK
SAELITQAWM KKNPEDRASS TVLQISKRFN ATSCLVVSEI ISCSDIDRRV ACIEKWAAIA
DICRCLHNYN GVLQICAALV NSSVFRLKKT WERLSKSTRQ MIDRLQLLVS SDGRFKNMRS
ALHNCDPPCI PYLGMYLTDL SFIEEGTSNV TEEGLINFCK MRMIAHIIRE IQQFQQTPYR
IEHNQRVCDY LLDTSRLIED ERAYAASLLL EPRVSICPES SPQTPGGRSG FKT
//
