ID   A0A1I8IEC7_9PLAT        Unreviewed;      1344 AA.
AC   A0A1I8IEC7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Reverse transcriptase domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0011665-snap-gene-0.3-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0011665-snap-gene-0.3-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0011665-snap-gene-0.3-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   WBParaSite; maker-uti_cns_0011665-snap-gene-0.3-mRNA-1; maker-uti_cns_0011665-snap-gene-0.3-mRNA-1; maker-uti_cns_0011665-snap-gene-0.3.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd15553; PHD_Cfp1; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 2.60.120.650; Cupin; 1.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR037869; Spp1/CFP1.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR002857; Znf_CXXC.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   PANTHER; PTHR46174; CXXC-TYPE ZINC FINGER PROTEIN 1; 1.
DR   PANTHER; PTHR46174:SF1; CXXC-TYPE ZINC FINGER PROTEIN 1; 1.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   Pfam; PF02008; zf-CXXC; 1.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS51058; ZF_CXXC; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00509}.
FT   DOMAIN          508..558
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          782..831
FT                   /note="CXXC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51058"
FT   REGION          469..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          575..787
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          842..869
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1214..1235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        480..499
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        580..614
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..707
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        740..757
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        758..775
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1344 AA;  145922 MW;  6E0DFD2A809FE4EB CRC64;
     MCNIYCYPPR RSSLPTEALR IHCVATEVAR VMNRVLSGEV APNEWTTAHI VAIPKKPGTT
     KLEEHRGICL QSCAAKLFNH MLLSRLQPVL DPYLRPEQNG FRPHRGTVTQ ILALRRVIEE
     AHIRQLTLIL IFVDFRKAFD SVVRDALPEV LRAYNVPELL ISAVMALYHG TTAAVSTPDG
     LSDFFETSSG RRSYLFWCLT GCYGLLCLPT TTASCCGDAW VDANRRDGSA CLATPMTLPC
     CPRPSRAPND SWIGWLPLRR ASAWWSTRRK TVVLCVPDDT EAAIFCRGAN GQASELPRCQ
     QFVYLGGLVP DVREDLRRRR GLAWAAFRSI RSVLQSEALP DRRCSRAALF QAVIETVLLY
     NAETWTLTDS LEAQVDAAHA GLLRAAFKIG NERVTNTALY HRAGLARPSD LLRRRRLQLA
     GHVIRAEAYC PEPVQEVLLL TLQAPYRRGQ ARTRRYVDCL LADAGAPDSA GGAAFKRGAA
     SKQRQQSGGG GTAASKKKSA SSASSDLQAW CVCRSTDIDR FMIACDKCEE WYHGDCIGVS
     SKDAAAINKF YCSKCLKKHP GLAIQYKKGR APVAVAQTGS ASRKRGQSQQ AGSEDKKTAA
     ASSAKASKSG ANHSGQPAAK RKRASEAAAA ASAPTPPARG RKRKSAATTD STSKQAAAVA
     AASNAAAPAG EPKKRGRRAA SAGKQQQQQQ QATKNSRKQQ QPSMPALVPN ANEDEDEDDF
     GLPQAEDLLL PAERRSRSSA ASSTETDDDH RRGISDDDDD SDDSDLDDDD IDDGLGVGGA
     GDGPAARRCG RCAPCLRVSD CGRCDFCLDM PKYGGRNRLL ERQRCRMRQC VTLDLALNAA
     GRRRRRKAAA VRPSGPGRAA RQPAAATSAS LWSDTPVPYA LPYADHTYCR HHGRGGTAAT
     SAGAAAGAAA SASPPAATGA VASSSRKSAL TAAAAAADMV GFYTLHPESD NLDITWPKDA
     DAERISLLAH PPQAAGQLAQ PLSPVVRPRQ PHDVPGTGDA FVVQPTNHAQ RRRQLPPIAA
     SVVVVGGCRL LRQVNAVLPD VRAADGERHE QVEGDLGELA ADADEGCQQE HRHGHCGRVE
     PFQRVMVMRD KDNVTRFRAW ARTAGRTAGR VRGAGISRQE VDETQTACLS PPVGCLQRQQ
     QHFLHRLWTL GLGSDDVASW SRGRRKSLLG RDRPASVRRI DLLFERIRQC PGLGVVQQDG
     LDHRLEQRRP LAVRQGLGLQ DSPHETEGNP SKSTATFDTC LSASRYSKHD GLLRVDPQAD
     ARSNAHKLVQ LALGAFDGRQ EETRRNRRIQ IRPHLSRLSN PSQLSESTSE LLHLSRLSGD
     PKARYWPMQV CSSSALAESR RAPH
//