ID A0A1I8IEE7_9PLAT Unreviewed; 976 AA.
AC A0A1I8IEE7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|WBParaSite:maker-uti_cns_0011892-snap-gene-0.3-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0011892-snap-gene-0.3-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0011892-snap-gene-0.3-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A1I8IEE7; -.
DR WBParaSite; maker-uti_cns_0011892-snap-gene-0.3-mRNA-1; maker-uti_cns_0011892-snap-gene-0.3-mRNA-1; maker-uti_cns_0011892-snap-gene-0.3.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0043933; P:protein-containing complex organization; IEA:UniProt.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 427..535
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 836..952
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 960..976
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..31
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 976 AA; 107112 MW; 39835A5BA0B8B843 CRC64;
PRFRSDLCPL APPGTGRPLP AAPLQPEPRP PVSRYELHPY ATRRLNTTIT PAAAAAAAAA
AAAAATVSLP EPGCTLICPP AEPIRSDLLP PAAALSASER YSTASQLPKT VSEQQLVANV
ANHRQNPQLH QPDPTKLANQ SDRQLLPASS SASSTAGRRP RVDEETGESL DKERVRVTLT
LTGLPGVMAN NMPSMMRSLS DMLGLEFDYE VQGAGGVGGS SAAARSWAPS PMQQHGSGPT
TPAPSPAASR HAEDPVSVSA LIASKQQHQP SVCAQCEAPV PPNCAVRRRL TAEGVEAPLA
PGAADSNSQL RSEDSNQPDY RRQLYIGDEL STVPVVLQSP LPTNRSKAME RQMSVGKSAM
QAGRRRTLSG EQRIGSQTKK WKGVRWRKYG SDFKPAQDFQ PLSPEEIGEL LGKMSGALKP
PAGLADLRVC VLCCQRGDLP ADGPGRLLNL HSGRWLHLNC ALWCFDVYET VSGGLVNVDT
AVRRALKTRC SHCNRLGAGL ACYRSRCTAV YHVICALESG CMLFTDRGMY CPAHRPKEHQ
LQLVSLEVPR RVYISRDEQT QVSAALMSDQ PDSTSLRIGG LRLRRLGQLL PAQISSGRFH
TNRHVYPVGY WSTRIYWSRL TVGQRCCYQC TIEESNGAPL FRVRVEETGR PTHELVADAC
DAVWRPLLVE IAQLRASAGL VKLFPRHLTG EDMFGLTESN VLRAIESLPG LDVLTDYAFK
YGRMQLIAEM PLAINPTGCA RSEPKMRTYF RRRHPICRCS APAPVGAASA GGPATIEEHR
GGVQMRAHLQ TGGSSSSRHA LPLSMANTIN ELAPYSKQYT HSKSSQYRRL KTEWRLNVYL
GRSRIQGLGL FAARDLERHA MVIEYIGEVI RNELGNRREK LYEAQNRGIY MFRLDDNWIV
DATISGGPAR YINHSCQPNC SAELVECDKE RKIIIVAGRR IDKGEELTYD YKFDFEDNAS
KIPCMCGAPQ CRKWMN
//
