ID   A0A1I8IEX6_9PLAT        Unreviewed;       246 AA.
AC   A0A1I8IEX6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=HIT domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0011880-snap-gene-0.3-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0011880-snap-gene-0.3-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0011880-snap-gene-0.3-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I8IEX6; -.
DR   WBParaSite; maker-uti_cns_0011880-snap-gene-0.3-mRNA-1; maker-uti_cns_0011880-snap-gene-0.3-mRNA-1; maker-uti_cns_0011880-snap-gene-0.3.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01276; PKCI_related; 1.
DR   Gene3D; 3.30.428.10; HIT-like; 2.
DR   InterPro; IPR019808; Histidine_triad_CS.
DR   InterPro; IPR001310; Histidine_triad_HIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR23089:SF33; ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT1; 1.
DR   PANTHER; PTHR23089; HISTIDINE TRIAD HIT PROTEIN; 1.
DR   Pfam; PF01230; HIT; 2.
DR   PRINTS; PR00332; HISTRIAD.
DR   SUPFAM; SSF54197; HIT-like; 2.
DR   PROSITE; PS00892; HIT_1; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
FT   DOMAIN          134..246
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           228..232
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601310-3,
FT                   ECO:0000256|PROSITE-ProRule:PRU00464"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        230
FT                   /note="Tele-AMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601310-1"
SQ   SEQUENCE   246 AA;  26804 MW;  8AECAD18212A3CE1 CRC64;
     MTSTASEPSE ASMGQCSLPG DSRKPSIFTK IIRREVPAKI LYEDEMVISF LGLPQNRVTP
     VQFLVVPKKQ LATLEEAHSC DEAALGRMFT VASLVAKQQG VTNGYRLVIN NASEPSEASM
     GQCSLPGDSR KPSIFTKIIR REVPAKILYE DELVISFLGL PQNRVTPVQF LVVPKKQLAT
     LEEANSCDEA ALGRMFTVAS LVAKQQGVTN GYRLVINNGN DAGQEVPHLH IHVFAGQPMS
     WPPGTD
//