ID   A0A1I8IFP3_9PLAT        Unreviewed;       393 AA.
AC   A0A1I8IFP3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Tetratricopeptide repeat protein 30 {ECO:0000256|RuleBase:RU367070};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0012438-snap-gene-0.4-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0012438-snap-gene-0.4-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC       role in anterograde intraflagellar transport (IFT), the process by
CC       which cilia precursors are transported from the base of the cilium to
CC       the site of their incorporation at the tip.
CC       {ECO:0000256|RuleBase:RU367070}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC       {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}.
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DR   AlphaFoldDB; A0A1I8IFP3; -.
DR   WBParaSite; maker-uti_cns_0012438-snap-gene-0.4-mRNA-1; maker-uti_cns_0012438-snap-gene-0.4-mRNA-1; maker-uti_cns_0012438-snap-gene-0.4.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; IEA:UniProtKB-UniRule.
DR   GO; GO:0042073; P:intraciliary transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR   PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR   Pfam; PF12895; ANAPC3; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW   ECO:0000256|RuleBase:RU367070};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367070};
KW   Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794,
KW   ECO:0000256|RuleBase:RU367070};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339,
KW   ECO:0000256|RuleBase:RU367070}.
FT   REPEAT          41..74
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   393 AA;  44526 MW;  8857F305B874F102 CRC64;
     MTHNIKEGQF TSTIYGMIKE HRYKEAVGAL NHQLTTHPDS RAALSLLGYC FYQMQDFVSA
     SDSYERLAQL CPESPEYQLY FAQSLYQAGL FQQAIKVVAQ IENPAYRSQM LKLEAAIKFG
     EEDFAGSRAL VDQCPKDDPD TLINIGCLLY KEGNYQEACA KFTQAMKVVS FRPDLAYNIA
     ICHYQMRQYA QALKFIADVI EKGIRDHPEL GVGMTTEGIE VRSVGNSLTL HETALVEAFN
     LKAAIEFNLH NVAQAQDALT DMPPRSEEEL DPVTLHNLGL MNMEADAAGG FQRLQFLLQQ
     ESFPPETLGN LLLLYVKFDY HDLAADVLAE STELAYKLLP SYLLDFLEAE AYRRLDEMAT
     RQTETLRKLT KMVQQARQKH DDEAVKRAVN EYD
//