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Database: UniProt
Entry: A0A1I8IFU9_9PLAT
LinkDB: A0A1I8IFU9_9PLAT
Original site: A0A1I8IFU9_9PLAT 
ID   A0A1I8IFU9_9PLAT        Unreviewed;       383 AA.
AC   A0A1I8IFU9;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   08-MAY-2019, entry version 12.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PAA65039.1, ECO:0000313|WBParaSite:maker-uti_cns_0012097-snap-gene-0.3-mRNA-1};
GN   ORFNames=BOX15_Mlig028496g2 {ECO:0000313|EMBL:PAA65039.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Platyhelminthes; Rhabditophora; Macrostomorpha;
OC   Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0012097-snap-gene-0.3-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0012097-snap-gene-0.3-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26392545; DOI=10.1073/pnas.1516718112;
RA   Wasik K., Gurtowski J., Zhou X., Ramos O.M., Delas M.J.,
RA   Battistoni G., El Demerdash O., Falciatori I., Vizoso D.B.,
RA   Smith A.D., Ladurner P., Scharer L., McCombie W.R., Hannon G.J.,
RA   Schatz M.;
RT   "Genome and transcriptome of the regeneration-competent flatworm,
RT   Macrostomum lignano.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:12462-12467(2015).
RN   [2] {ECO:0000313|WBParaSite:maker-uti_cns_0012097-snap-gene-0.3-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:PAA65039.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA65039.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA65039.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a
RT   flatworm model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; NIVC01001690; PAA65039.1; -; Genomic_DNA.
DR   WBParaSite; maker-uti_cns_0012097-snap-gene-0.3-mRNA-1; maker-uti_cns_0012097-snap-gene-0.3-mRNA-1; maker-uti_cns_0012097-snap-gene-0.3.
DR   Proteomes; UP000095280; Genome assembly.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095280,
KW   ECO:0000313|Proteomes:UP000215902};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     62     85       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    161       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       29    167       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      174    344       IRK_C. {ECO:0000259|Pfam:PF17655}.
SQ   SEQUENCE   383 AA;  43771 MW;  106F0C799E5141D7 CRC64;
     MEREYPKRKS STHPDRVGKR RRYKRLLFKN GDMNITQCSV KDRRRRYLAD IFTTLIDSKW
     TYAVLLFVAV FVLSWLIGGL IWLLVAFSRQ DTIPEKADSA RCVYGVSSFV TAFQFSLETQ
     HTIGYGTPRT ANSFCPEVVL FVMLQSVVGV LIQAFMTGFI FSKLTLPGKR AGAIMFSREA
     LVTKRDDQMV LLIRVGDMRR SQLMEASIKG TLVRKRITRE NEILPLEQFR VDFGASTGRD
     RLFLPFPAIV EHRIDEKSPF WDISADDLQH EQFELVVALA GVAESTGSTA EARTSYLPSE
     IRWGYNFERL VTYQKENGRY QIDFNKFNST RPTPLFPRMS ARQMAGLCEA NLRLFDAPAS
     AGSRISAIDE TQTVNPEEMD TYL
//
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