ID   A0A1I8IJS0_9PLAT        Unreviewed;       238 AA.
AC   A0A1I8IJS0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   22-FEB-2023, entry version 24.
DE   SubName: Full=UBIQUITIN_CONJUGAT_2 domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0013467-snap-gene-0.5-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0013467-snap-gene-0.5-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0013467-snap-gene-0.5-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC       {ECO:0000256|RuleBase:RU362109}.
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DR   AlphaFoldDB; A0A1I8IJS0; -.
DR   WBParaSite; maker-uti_cns_0013467-snap-gene-0.5-mRNA-1; maker-uti_cns_0013467-snap-gene-0.5-mRNA-1; maker-uti_cns_0013467-snap-gene-0.5.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd00195; UBCc; 1.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR023313; UBQ-conjugating_AS.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   PANTHER; PTHR24067:SF157; FI11905P; 1.
DR   PANTHER; PTHR24067; UBIQUITIN-CONJUGATING ENZYME E2; 1.
DR   Pfam; PF00179; UQ_con; 1.
DR   SMART; SM00212; UBCc; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   PROSITE; PS00183; UBC_1; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362109};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362109};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|RuleBase:RU362109}.
FT   DOMAIN          1..161
FT                   /note="UBC core"
FT                   /evidence="ECO:0000259|PROSITE:PS50127"
FT   REGION          183..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..238
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        82
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10133"
SQ   SEQUENCE   238 AA;  26576 MW;  DE675C7D4D995A10 CRC64;
     ALQQELKSLN EEPVEGFKVK LKNDENIFEW NVVIFGPPGT LYQGGYFKAL MVFPQDYPYS
     PPSISFVSKM FHPNIYDDGK VCISILHPPG EDPVSGELPS ERWNPTQNVR TILLSVISLL
     NEPNTSSPAN VDASVMFRKW KENKGDDYVK IVQKQVELTR KDADADGIVV PVRVEDYVVK
     SRTTSTSVGG GSGGFGGGSH ADQDNNDSDV PFEVYDDQID YDDDDDEDDE EEEDDEED
//