ID   A0A1I8ITL7_9PLAT        Unreviewed;      1203 AA.
AC   A0A1I8ITL7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Cadherin domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0015966-snap-gene-0.2-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0015966-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0015966-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I8ITL7; -.
DR   WBParaSite; maker-uti_cns_0015966-snap-gene-0.2-mRNA-1; maker-uti_cns_0015966-snap-gene-0.2-mRNA-1; maker-uti_cns_0015966-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 2.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   PANTHER; PTHR23049; MYOSIN REGULATORY LIGHT CHAIN 2; 1.
DR   PANTHER; PTHR23049:SF34; MYOSIN REGULATORY LIGHT CHAIN SQH; 1.
DR   Pfam; PF13499; EF-hand_7; 2.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        962..981
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          782..817
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          851..886
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          111..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          923..943
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          996..1045
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1002..1041
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1203 AA;  131284 MW;  7EDB069C8BE9C3D2 CRC64;
     AASEENGRHH FADAAIATKL ERSIFVVDNP LPTLLLGLMG RRSRPKRPPS NLGRHEVGEL
     NAGLHLVRAE LVGHPASGQL RHFKVLVQDL NDAAPTSQSP LTDLRLNGVE QQQRLRRTQS
     NSAANHEDRR PEWPSRSGSV QTTHTASTGM ALDPEEPHAA SGVMWLQSCP AETGPGLPLA
     CRGQSSVAAG RHHDSNGSWS DIQLAIKNRI LDSPAIGRSL GVQYRNWTDG THELSRLRAT
     PKHLRQSFPS YRIKRRPESN TELLQCQYIR IECRVPILNS QRLSDGRRIQ NAILDCQPNV
     APVAAQPDPL NSWLLLCTNS LYLALEFTLK QAPSSADLST PNWSSMAKVR GSNRLCRPLL
     KSNAATRPST CGGGDADGGG GELPSDASVL HTNLCLLWHL SLRSRPADSV TQFTVQSALS
     GEAGVQLDEA EPHRVEQLCR LAAVDSEAEL VHKVQLRLGE HRRQLRRVSL AVEVGLVEVG
     LKLRHHVALL VVQPPAAGTS ALRPPPQVDE TAGVGAQLAH KRVPLVIQRV EPPLTVTSDQ
     RLVNAVQLRE VVSLEAPYAA AVRPPVACRV GQTVEVGAEQ TDPGVSAVRQ SAYQSVLLLT
     LDGRELSPVR CGCPSHVSLW SCDRDSSRVA EAARAIEKVA QLRVGGMRCL GNVIESCCAV
     CRRNLGFGTG TRGFREISNL KWQAAARLGP IDLTPAIQQQ LFRRQPIRMK SEPAKQPLVG
     LMSFEPRIKV SATDRELPDP RLLSTGRQRR ISTGRDFYFE LKQEGKRAQR ATSNVFAAFS
     QTQVQEFKEA FTMIDQNRDG FIDVEDLKDM YASLGRQPTD KELQEMLKES PGPLNFTAFL
     QIFGERLTGS DPEDALRNAF KMFDDANTGM LDEEYFKDLM KNMGDNFSEE EIRQTWKEAP
     ISAGKLDYNK FTNLIKRGKD DERLKGTASA SDNSDDYAAG ASSSVPIDAQ GCCRDDRSGR
     RIVCSALVLL LLLTLLLLLL LQRSVEARIS GGNIKGGEGT ATSPWPHQQS QPQSWPQQSG
     SPGISDSAGC RQPAQSCTEH RSRVRTGTER LLTPMNLRNR TRNSTRAGRQ SLITMLIVDG
     EAINTADSAD FNRTIESIAE LSWSISMELA LSRCSGDEAG EAEEFDALII IMSSLQRWHR
     ALARFAAALV SGWQWNTDSG DSATEAAAAA DELEASGDAA RVELLGAESG GGLCTGDGMM
     AAA
//