ID A0A1I8IUX9_9PLAT Unreviewed; 2047 AA.
AC A0A1I8IUX9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|WBParaSite:maker-uti_cns_0017596-snap-gene-0.1-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0017596-snap-gene-0.1-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0017596-snap-gene-0.1-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR WBParaSite; maker-uti_cns_0017596-snap-gene-0.1-mRNA-1; maker-uti_cns_0017596-snap-gene-0.1-mRNA-1; maker-uti_cns_0017596-snap-gene-0.1.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:InterPro.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19172; SET_SETD2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044437; SETD2/Set2_SET.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF600; GLUTAMATE RECEPTOR 1-RELATED; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..2047
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009321234"
FT TRANSMEM 606..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 798..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1803..1858
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1860..1978
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1985..2001
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 859..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1440..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1606..1649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1716..1789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1345..1360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1440..1454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1467..1493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1613..1634
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2047 AA; 224792 MW; D5D4970C80136C9B CRC64;
ATISQHRGVP MIGLIQLSSL LIQLLLISCG SSAAAPLRIP VGAIFDASQE QLKNALFLAV
ESFKSDRFEL LVNYTVTNSN SSYNMQRRLC QYLFPSGAFA VFGSTNALTV DGIQNLVSVF
HVPFVTSGIV KAENPKGQDY MLNLRPRHVM AIIDTLDLYK WSNFAYLVNS HEGLHRFQEI
LREYQRRHVY RDVNVQIIYL SDTRFVYPDL ARLDSLLKAE DRKHVVIDLD PPEAVSNFLY
QIHEMGMNRR EYHYLISGIS ALDIETEGMH YSGVNVTGFQ LVNESQVNVK SLKQKWLQLC
QQKRWDCSRG GNSLPLYEVA LLMDGVETFA RAIDSLLGQV TFDENGFRSN FSIQLMELEG
TKSFQPAGGW HTNLGLQRQL ISSGNASTAA ANFTKVIRVV TIKSEPFIQP RETKPNEPEP
VGNDRFEGFC IEMFKKMAER LGIQYRIHFV RDNQYGRIDK KGEWNGMIGE LLRNEADIAL
APLTITTERA EFVDFTEPFL TFGISIMIKK PKKEKPGTFS FLRPLSPEVW SYILTGCLGV
SLGLYLCSRI SPLEWQVEFE NELPPVHKVT RDFTVSNSFW FSFAAVVNQG IDLSPRSSGT
RVVASAWWFF TLIMIAYYTA TLAAFLTVEL LRTPIDSWED LAESKEILYG TLNSGSTKAF
FLTTKLPPFD LIGINMQKNE KKGLGVYVNT SEDGIRKVRE SKGRYAFLLE SKTNEFHNNR
DPCDTMMVGQ PFGDKGYAIA TPKKSPFHEK LNDAVLQLRE AQVLAQLYKK WWIEKGQCIS
DDSGGGGLSA LTVVNVAGVF YILVAGLGIA LAIALVEFYF TNRREAAKAR LDDSVVTAAA
RALRRSAVAA ATVTAACQRR SNGKERDDDE AATGRREFAG PVHVHQSSSG YGLKTCAFSH
RSDHKLKNFI SSKCSDGGPS LRTLRQSLIQ TQVADALQVL HQAEANPLDR FACLEESLSH
LLVASGELWS WRSWCNGGLL TRGSSGSLLA KRSSVGSLLA RRSSGGSLLA RRSSGGSLLA
RRSSGGSLLA TGEAQQRRQP AGVALTVEHL LEAEAEPSDA RVQRCRLPIL DSRVPRRLAQ
GQSRMVARFG GVGPFTCSRW LDVGDGGLGR LLESPGSFGR VEQRNGASIS ADADGLSRGL
DALGAGGVGG LGAGGGVGVL AVLELGLAVL ELRLLISRYP TGLRPAILLR YYLQAETQEF
PAKAKTKSCE SLDIKQSLSQ SPPKVVDELT DSKSKQSCLS KSELERKRKS VSKLDKGDLR
HQIDSHSKRH RATKEAIADN EANSSASERG SSKPRVDSNK DKRTKKKNRH KKSSATRETV
DKEDKKSIEK SQKSLHRHRS KASKIERQSR PLESKSRSRS PSKRRSFSKP MAKPPDSPTI
EVKVAFGAQI PAAGAEAPIQ VNIPTTASSK AAVDVQKKVK VKTALSTPIA FKVKVAIQAK
KSESSGNNWR NRHARSPPRS AARKSRDRSS SLSSTGSSSS DGGSSSSSAD VKPIVTSRPP
PPPVSDGLTV AFPSHVGLYP AASYYMQQPP LGYYHGQQYA YDPMQAYQQQ AAYSANPAVY
QNGYQTAVDP NYFPGYSAAA YMYAQPQAVQ EDPTQYAAPL DPAFTANGQV DETSVPPPPP
PPPPPPPPPE DAEKPKPAAA ATADEAPPQI DGQLSRYREF FAKQFGNSSA GCGAGAGGDL
QQEATTNGKV APSLGRALKP HSTFAYFLEK FQPVSTEADQ TSDATPGPPA VDSQESKKPE
TVRNSGKSSP PKPEEPQPST AKADVSNDVA PSFPGCEPGG PPPPKYEHID SNVYLRSQPK
LAFRAWLCDC TLPSEEGQLN KDYKACTDEC MNRLLQIECT DRCNCGAYCT NNQFANRRYA
PLTPFYAGPA KGWGLKTTAE VPAGAFLIEY VGEVIDFAQF KRRIIAYEKS GCPHHYFMSL
ESDVIVDAGA KGNWARFANH SCSPNSDIQK WTVGRQQRVG FFALRDIPAG EEVTVDYGFV
QYGRELQKCY CNSPNCTGVM GSRSQQLQDR VQARDSSARD RQVARLLRLD RLGSPDDARC
LVRLLVQ
//
