ID A0A1I8J7K6_9PLAT Unreviewed; 934 AA.
AC A0A1I8J7K6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=EGF-like domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0046012-snap-gene-0.11-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0046012-snap-gene-0.11-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0046012-snap-gene-0.11-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A1I8J7K6; -.
DR WBParaSite; maker-uti_cns_0046012-snap-gene-0.11-mRNA-1; maker-uti_cns_0046012-snap-gene-0.11-mRNA-1; maker-uti_cns_0046012-snap-gene-0.11.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR PANTHER; PTHR45836:SF13; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF12661; hEGF; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 861..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..40
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 598..632
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 644..682
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 683..719
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 721..758
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 760..796
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 116..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..350
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 30..39
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 622..631
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 653..670
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 672..681
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 709..718
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 786..795
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 934 AA; 100646 MW; 8F1086153ADD6579 CRC64;
SEPSTTPCGS FECINGEVCN DTGNDSFCSC PWPYSGDACN ITDDHTEVLP GKLICRQPDV
VERNKRPDST ESALNDGHHY IDATAYLNAG INTGDEELGD MSGTNASSVV VAEQQIESVH
DSSKWDTAER PGRPFRKDRV LAPSREVPQF RMIWFISSSL LDSHEQQAAA DDKEDNKSKK
RSKEENPKSS AKMSLISKTS SKLRKLLKTT PAAAGQSASQ AGTSGLKNTV EEADPNATGE
DQEENQAADF GGNSGDDFYC APDANQTPDS DLVADGGESA DDVYVAPDAH QTPEPVAEQQ
LSENTTASNP VELDEFYACP DNPLDQSSSQ ATQPPDQPPS KPPTSGGSKP KPNPKPRHLQ
KPQKQQQRQQ SSVPPPLPER HAMRTQNQLL TAEESAANLE DPGNVYDELD NHPTSLPDSS
GGQQQPQAAK IDLPARVPAR LDAKDKANLK RRIREKSKRF SIHDGALYYR VTNKDDSQRM
RPEDHRRVLF TEEEVRDKIR SLHSKGSHVG VNSTVSLFTA RYYADIPVTP IAMAVVESCD
RPRTMSSRHQ SYLSNLSAIV IGFSYCFCLL SAAGSAKDTI QQLDPDGVDD FSLLNRQRRE
TCDSLECVNG GICNSSEPVC SCPKPYSGDN CSVTDDYCSK LQPDMGIDSL PVCFNGGLCS
PIETEPFFNC SCSINYTGNR CELFEACSIR KPCSNGLCVG TSSGKNCSCF AGWTGASCAT
NVNDCQTGLC KNGGECIDGN STYTCNCSKT DFSGPNCTNP INDCQPNPCV NNGTCVDGLR
NFTCQCLAGF SGRNCSIDHP DCIPNPCPRE FSLPRAKQSK SVRHSVSASS VQWPVSVLLA
AGYVCDKGYG SELLKERHMG IGIGAAAGFA ACALLAVIII LAVLGAYKHA SHSQNAAGDG
IMSPSRLEAR PSQAHPTTAT VMQSLLTVGA LMWT
//
