ID   A0A1I8J844_9PLAT        Unreviewed;      1429 AA.
AC   A0A1I8J844;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=PWWP domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0046204-snap-gene-0.2-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0046204-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0046204-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   WBParaSite; maker-uti_cns_0046204-snap-gene-0.2-mRNA-1; maker-uti_cns_0046204-snap-gene-0.2-mRNA-1; maker-uti_cns_0046204-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd15489; PHD_SF; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   PANTHER; PTHR36688; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR36688:SF1; ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00855; PWWP; 1.
DR   SMART; SM00249; PHD; 3.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR   PROSITE; PS50812; PWWP; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          306..365
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|PROSITE:PS50812"
FT   REGION          166..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1429 AA;  161997 MW;  574FF2D48710F8CF CRC64;
     MEPSFVVLGD MLEKILLPFF EQQQKQGDAD SRDDEAEYDT KAMTLQRPWD SFIKENRAEW
     KVRAEKEEAE KKAKAAATEA EAADKKQYGV MIQRHWCGLQ FSSAANKRRL RASGSSEVWN
     ACTLPPGLNP PPFLPACRAA ELQHSPQAFK WRAVLRQTLI SSGGRTKEDI MPTYKTTPTS
     GRKNRRKEED LRRIRCGDVE VNPGPVENKN ERERCAVCSK MAGGRGPRCA ECGGVMHLKC
     SDLTRSHFYR MEGANASNAW TGPCCRVEER RKEEEDEKPV TEAADVEGVK GRERTEAGKA
     SESEDEGRVV WAKLTGWPWW PALVLKDGDV ELEKRKGKEV EKVKWLGNGE WTSKISTRLV
     EEFEENYELR HQKHRRGAYD KALAQAWEEV EKRKIRNTVS AELKTNGSVE VGRSDQTGGG
     QEAMEVKECE HVGCTECNKK MRASTIGVAC TLCERRAHRT CSGLSRWRAG KNAAWTCRGC
     SVQGTLPLER RDMESRAVRC AECLRYCRRN VGACCAICSK RMHWSCVGEV SRKRLEEWKV
     KGGWKCNECT ADLAKQAKNR KEAERDEGMS GQGSEATEGH QTCWKILQWN CDHLHAKSTE
     LAKLLDEEDV DVALIQETKL RTEDPDPCIP GYALQRSDRR REIGCWKARG GGLAIIVKEE
     WSFKKLKIPS EQGEGRLESM AVEVQKGDGS KLNVLNCYMP PGEDGEWRKS LNRLPSGEKW
     IVGGDFNAHD EAWDGEVEED ARGSTLTEWA DDRNLVCLND GSATRVSKGT GIRSTPDVTF
     CHNTQEQQWS WSTLQKLSSD HLPILLQAGG GKTEEKARRL IRWNWKKADW EAFRDRVEAG
     YREQKVNCRS IAGVEEGARR VVLTAARSCI GTKVITTKNR NLMDEEVRNV LEERDRALEE
     GNGERWMELD GNAKELIRDK KRQEWRQHLE SNATSLKMWN VLNQLKGKKG EEELGEVLMH
     GGKEYRSNGA KAGAFAKEYA KVSRVQVPRS HGWAKRQVTR LLSEEGPDTC EGRELSMAET
     RQALNEMDGN KAAGPDKLRW EANPKFLGIT YDSRLSFTKH VQEICKAGKG RIQMIRKLAG
     SDWGWHSKLL RQTYTAMIEG KILYGSTAWM PWLSDRSWAK LEVLQRRATR VIGGLLATTP
     IEGVREESGT EELRGKASGR AVQRLDKLLR CKEGSIRRRL AEEKGAGRLS RRSWNRWAWK
     LLKEWHLEVA RFEEEDPERP GVEWRGVSII AEGRRTDVEE ECKAMGMERI KEASEGADAV
     IFTDGSVNSK GAGGGGMVVL SGDLEQTLAS KKIAGGRVAS STQAELYAIW EATRWLAAEQ
     DNWSKAVRDP GFNCREDEVS YRRMRTGHSI ELAAYRRRIG LQEEGRCRGC GMEDETMEHI
     WDCPATDGRR RMWCCEGMQA VCEQPEEARS YWEWWRSLPQ WGASVEDEN
//