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Database: UniProt
Entry: A0A1I8JBF2_9PLAT
LinkDB: A0A1I8JBF2_9PLAT
Original site: A0A1I8JBF2_9PLAT 
ID   A0A1I8JBF2_9PLAT        Unreviewed;       243 AA.
AC   A0A1I8JBF2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   05-DEC-2018, entry version 9.
DE   RecName: Full=Superoxide dismutase {ECO:0000256|RuleBase:RU000414};
DE            EC=1.15.1.1 {ECO:0000256|RuleBase:RU000414};
GN   ORFNames=BOX15_Mlig028734g3 {ECO:0000313|EMBL:PAA91509.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Platyhelminthes; Rhabditophora; Macrostomorpha;
OC   Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0046798-snap-gene-0.4-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0002170-snap-gene-0.44-mRNA-1, ECO:0000313|WBParaSite:maker-uti_cns_0046798-snap-gene-0.4-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26392545; DOI=10.1073/pnas.1516718112;
RA   Wasik K., Gurtowski J., Zhou X., Ramos O.M., Delas M.J.,
RA   Battistoni G., El Demerdash O., Falciatori I., Vizoso D.B.,
RA   Smith A.D., Ladurner P., Scharer L., McCombie W.R., Hannon G.J.,
RA   Schatz M.;
RT   "Genome and transcriptome of the regeneration-competent flatworm,
RT   Macrostomum lignano.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:12462-12467(2015).
RN   [2] {ECO:0000313|WBParaSite:maker-uti_cns_0002170-snap-gene-0.44-mRNA-1, ECO:0000313|WBParaSite:maker-uti_cns_0046798-snap-gene-0.4-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:PAA91509.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA91509.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA91509.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a
RT   flatworm model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC       {ECO:0000256|RuleBase:RU000414}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU000414};
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family. {ECO:0000256|RuleBase:RU000414}.
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DR   EMBL; NIVC01000085; PAA91509.1; -; Genomic_DNA.
DR   WBParaSite; maker-uti_cns_0002170-snap-gene-0.44-mRNA-1; maker-uti_cns_0002170-snap-gene-0.44-mRNA-1; maker-uti_cns_0002170-snap-gene-0.44.
DR   WBParaSite; maker-uti_cns_0046798-snap-gene-0.4-mRNA-1; maker-uti_cns_0046798-snap-gene-0.4-mRNA-1; maker-uti_cns_0046798-snap-gene-0.4.
DR   Proteomes; UP000095280; Genome assembly.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.287.990; -; 1.
DR   Gene3D; 2.40.500.20; -; 1.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095280,
KW   ECO:0000313|Proteomes:UP000215902};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000349-1,
KW   ECO:0000256|RuleBase:RU000414};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000414};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095280}.
FT   DOMAIN       43    121       Sod_Fe_N. {ECO:0000259|Pfam:PF00081}.
FT   DOMAIN      128    231       Sod_Fe_C. {ECO:0000259|Pfam:PF02777}.
FT   METAL        65     65       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       113    113       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       198    198       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       202    202       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:PAA91509.1}.
SQ   SEQUENCE   243 AA;  26619 MW;  B9E78E983BAEE06D CRC64;
     LFSSNMHCIG SKLPSAVRLC QRLCIQPLSG AAQAPQPIVK AVLPDLPYDY SALEPVISAD
     IMRLHHQKHH ATYVNNFNSA QETLAAALAA GKASDIIAVQ AALRFNGGGH VNHSIFWKNL
     SPQGGGEPSQ FLLEAVNRDF GSFSKFQEQM SAAAVGVQGS GWAWLGYNFK TDRLQIATCA
     NQDPLKATTG LEPLLGIDVW EHAYYLQYKN VRPDYVKSIW KVINWDDVEN RLDQAKSGGV
     KLA
//
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