ID A0A1I8JI13_9PLAT Unreviewed; 2481 AA.
AC A0A1I8JI13;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Protein kinase domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0047814-snap-gene-0.4-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0047814-snap-gene-0.4-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0047814-snap-gene-0.4-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR WBParaSite; maker-uti_cns_0047814-snap-gene-0.4-mRNA-1; maker-uti_cns_0047814-snap-gene-0.4-mRNA-1; maker-uti_cns_0047814-snap-gene-0.4.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0006259; P:DNA metabolic process; IEA:UniProt.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48016; MAP KINASE KINASE KINASE SSK2-RELATED-RELATED; 1.
DR PANTHER; PTHR48016:SF29; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1A; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}.
FT DOMAIN 11..282
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 418..667
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1694..1997
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 2239..2378
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 1058..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1149..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1233..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1681..1712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1693..1712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 446
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2481 AA; 273581 MW; 7CBD5A63A0ABBCC8 CRC64;
LSADCRVSWR WDVVRLIGRG GFGEVHEVRT DTGVTCAAKT LRMPVQLGDE LPSVSSEIHR
AVESERNLCR LRHPNIVRFL HMAQPEPATV VVFMELLDGR SLERFIDSKP LDEPKIRDFS
EQICRALLYL HSRQPPVIHR DINCSNIIVH ADNTRIKLID FGLSIKLEQS VSHMSASTQS
PKGTLNFMAP ELLGAGESDS VQYSRESDIW AFGCSVFQMA SGARPFRGNQ SVYQVALKIA
NSGAPALPDG RSAELRDFYS RCTAMDRRQR KDAQELLEHE LLARPSNLSF AIVLWALSLA
GLELLGWLGR GEYRPHSFAS MCSQPQPQAS THGWAPQRKD MQRPHTAAQL HTALRVPAHE
LDRAFSRLGR LQSDCLRRLG NQLKGTWHFM APEDAHDAEG AKKQLDPSFT DWDFILQDNK
KQLIGRGGFG EVYKALTDRN QTVAVKVLPL SGTGQSRKLQ KAVEMEKRGV EIIKRLSHSN
ILQFLKCEQK SDGLYIFTEL VSGHSLFELM QRQNKPFKES GPEGAILHRD IKSSNIMLTN
EGVIKLIDFG LAKEIVGTCG LSTGVDPKGT PYFMAPELFM GEGDSIPYSA KTDVWAFGCT
VYELTAMQPP DANVQHFRIA VLRCGGRAMP RIADGFSAGL KDFYLRCVDY DPRKRADTAE
LLRHSFLSAS SQLKCGFAVS VFQTPVRTRV QQNPTDRGSG GSWSVLRRQH ERRVRRMIPG
IRQGPGVQQS GGCDRVATTG SVVQAVVSSD VSAGGVSQLQ QLLPQFLIVA LAIASCPHRG
GPTPFLFMPI ARRNVYSCQT VEVLQAKQAF SFVLRLLGSF AAAVLLRRVR TLSFLLVGLC
PLNVTPLPQQ MQQVLGAAPA SGLSRLHQRG QALAVLQPLS IERHQRQKPH VVLSGCQMRS
RVARLPLHLV KVTLNDQLCD SLEPSSGCST RFTAAECSGE HLVVGHSAVK LDLEGVVRLE
GLANLMMAAL TQYARICKLL IRCVVTYRTR LELKNSASKP ELGLQIVEQL AEKADLRNAP
SLVSASEPFC QLRQSPYSLL AILRNGVYRL SRLQQQQQQQ QQQQQQQQRG QEGTLRANTM
GSPDAPGPRN RTEATNGLHN QRCSIWSERA NTACMETEPQ QQQQQGQQIS TDAPHAESLP
TEQVLRLRGG CDHPDRRPKH GRRRNTAESG PELILQFNCN GVKSRHTELA KWLHVNRPAA
VLLQETKLAR DTDYIPPTGY YVAARCDGLP KEAAGTRATE NKEGGAPLQP TQPSGPEANP
NEGASADNCP TPWANCGRKI KRPRCRIRWP ADKNDKAEWC RGCRSGRTAC TRRDEPWPQP
PQPQPQAQTQ SAQHNREPTD NQQEQARRTA ASKPPITRPK NRTNKATHTR GGTLILVRAD
IASDTTPSPP DNERQLLDCA TATIHLKGQE PITLVSLYAP PTSNQRGETW QPPLHLVPNA
TGPTVVAGDF NAHGSWDRHQ DEDERGKIVE AWATSRNLRL ANGDYHTRTN PATGGKSTPD
LTWTSNNLLQ GIAEGWTTLD DLGSDHLPIS FPVQRHPRAP RKGKNLPRAT WCFRKADWGS
FKDELTKIDG QRADYPTHGV QLAHLHAIIC NDILTAAAHN IPKGARTAAK PFWTDACAQA
TRECKEARHV AELSPSDDNL ARFKAARNNS RKVIRQEKRR AWSEKAAELT INSDLFRTLR
QMRGDGPKPN SGASLQRKKT GQQEPSRPAR TNLEKANLFC QQYAAVSRVK GGPQDAHTNQ
AARAALNSSC TCNGSRTDMC SAFSLTEYRS AVRSLKSGKA PGPDGAGFRR GRSTEELIAS
TCQDIFDGLE AVPHLRSVLC LLDFSRAYDR VWRAGLIAKL KKLGIPNDVL RWIRSFLADR
RARVRVGNCL SNERIFKEGL PQGSVLAPLL WVVYINDLDT EIKEAHTDCK LKLYADDSAL
LATDRSLDAC AAKLQPALDA VHKWCQTWKV ELSAAKCVYG TFTLDPKETN GKKKVSLTIG
GQPLAHDPAP RYLGVRLDDQ LAFNKQGADV RARMCARRRP LAALANRSTG ADHHTLRAAY
VSTVRAVADY AAGTWLCGAA PSTRHSIERQ QAACARIITG CILPSDTRSV LRLAELPPVS
HVASERAARL RERILRLGPG AAAHEPATRS TRPRLKNRTY EAGQRRPTTT DAQIDTPHID
LRDTRRPFRN CWRRAALEMP ASVDLDQYIR DDICSPGIAP WEAHTDRIRF CLEAASRCSK
SDPSADRNAA ARDTLEDLPE ADINIWTDGS VADGTGPGGS AAIIGTNLVT FVRKSPAGRF
CSSFDAEMRA IKDALTFVAE KIAPRAARIR LCSDSLSSLT ALQAGPLDQR TESGLSCWRF
LISLGTCDLN DIDLAWVPAH CGIPANEAAD RAANAAARLP QTTAAISLGA AKAAIRRDRR
ALDDSAMPPA WPTFHARSRT EHTAVCQLRA GASMLAAEVR HRFGLTDSPL CQDCGAPDSS
LHAIYSCPRG DAHRTRLVGT E
//
