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Database: UniProt
Entry: A0A1I8JJL4_9PLAT
LinkDB: A0A1I8JJL4_9PLAT
Original site: A0A1I8JJL4_9PLAT 
ID   A0A1I8JJL4_9PLAT        Unreviewed;       993 AA.
AC   A0A1I8JJL4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   08-MAY-2019, entry version 13.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Platyhelminthes; Rhabditophora; Macrostomorpha;
OC   Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0048065-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0048065-snap-gene-0.2-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26392545; DOI=10.1073/pnas.1516718112;
RA   Wasik K., Gurtowski J., Zhou X., Ramos O.M., Delas M.J.,
RA   Battistoni G., El Demerdash O., Falciatori I., Vizoso D.B.,
RA   Smith A.D., Ladurner P., Scharer L., McCombie W.R., Hannon G.J.,
RA   Schatz M.;
RT   "Genome and transcriptome of the regeneration-competent flatworm,
RT   Macrostomum lignano.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:12462-12467(2015).
RN   [2] {ECO:0000313|WBParaSite:maker-uti_cns_0048065-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   WBParaSite; maker-uti_cns_0048065-snap-gene-0.2-mRNA-1; maker-uti_cns_0048065-snap-gene-0.2-mRNA-1; maker-uti_cns_0048065-snap-gene-0.2.
DR   Proteomes; UP000095280; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 2.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095280};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       89    379       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      449    866       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      897    970       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   COILED      568    592       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   993 AA;  110329 MW;  76FE2D1ECCB83600 CRC64;
     MFEEEADAAA AEAADAADVA AIIDADAASA AAASAGADAK KWRRAPLPHA ADPATQPLMF
     QQMDLDCYTL PAAGSGSGAS PVVRMYGITE AGHSVLVHVH GFNPYFFVPA PEGFSPADCH
     SFKQALNQAV LKDLRGNREG IVEAVVAVRL VDKESIYGFH RNRKQPFLRV TVALQRLMAP
     AKRLLEQGFS WQQGRGSHCF SLYEANIDFE IRFMVDTGLV GCCWVELPAG KYTLREKENR
     LAPQSRCQLE ADVASWSDVV AHPAEGVWSK VAPLRILSFD IECAGRRGVF PEPERDPVIQ
     IANMVVRHGE TDPFIRNVFT LGTCASIVGS QVLSFKTESD LLAAWSAFVR DVDPDVITGY
     NIQNFDMPYL LKRAATLKAE SRPLMSYHFL HEQKEDVQHS IITELQNGNE QTRRRLAVYC
     LKDAYLPLRL MDKLMCLVNY MEMARVTGVP LTFLLSRGQQ VKVISQLLRK AKEQDLLLPT
     QKVEQGDEYT GATVIEPVKG YYTTPIATLD FSSLYPSIMM AHNLCYTTLL DQASIAKYSL
     QPDEYIKTPC GSYFAKKNVR KGLLPEILEQ LLNARKRAKD DLKNETDEFK KRVLDGRQLA
     LKISANSVYG FTGAQVGKLP CLDISSSVTA FGRTMIMETK RYVEERYTVA NGYAHDAKVI
     YGDTDSVMCR FNAATVADAM KLGREAADYI SSKFPPPIKL EFEKACTSPS RTSTTRWTAK
     ALKRFAADNS PLVANLVNAC LHKILIDRDP DGAVQHAKSV ISDLLCNRVD ISQLVISKEL
     TKTDDEYAGK QAHVELANKI RKRDPGSAPQ LGDRVPYVIV SAAKGTPAYQ KAEDPIYVLE
     NNVPIDTNYY LENQLANPLL RIFEPILGDG KARSMLLSGE HTRLVVWPLL LLGRAACLGC
     KAVLPQDAAN GAVCKHCEPN ESALYQREVG VLRVLEEKFN RLWTECQRCQ GSLHEDVLCT
     SRDCPIFYMR KRLQKDLADQ DALVGRFGEP CDW
//
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