ID   A0A1I8JRB3_9PLAT        Unreviewed;       835 AA.
AC   A0A1I8JRB3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=CUB domain-containing protein {ECO:0000313|WBParaSite:snap_masked-unitig_39581-processed-gene-0.0-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:snap_masked-unitig_39581-processed-gene-0.0-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:snap_masked-unitig_39581-processed-gene-0.0-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A1I8JRB3; -.
DR   WBParaSite; snap_masked-unitig_39581-processed-gene-0.0-mRNA-1; snap_masked-unitig_39581-processed-gene-0.0-mRNA-1; snap_masked-unitig_39581-processed-gene-0.0.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00041; CUB; 4.
DR   CDD; cd00054; EGF_CA; 1.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 4.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR24251:SF37; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR   Pfam; PF00431; CUB; 4.
DR   Pfam; PF14670; FXa_inhibition; 1.
DR   SMART; SM00042; CUB; 4.
DR   SMART; SM00181; EGF; 1.
DR   SMART; SM00179; EGF_CA; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   SUPFAM; SSF49854; Spermadhesin, CUB domain; 4.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS01180; CUB; 4.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          58..181
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   DOMAIN          181..225
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          372..488
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   DOMAIN          530..656
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   DOMAIN          657..808
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          814..835
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   835 AA;  91027 MW;  B629E8289028D7ED CRC64;
     ESGEFGSAAA TSELSSGSGG GSGSGEVRCE WQISATQGEK VQIDIKWLDI QAEHNRQLRG
     ALPGDSETDI TGLTAAGAYR GDKECIWKIE VPTATQWRSS SSLLRSGLQF IDPPAAETHT
     QCVYDFVEVL EGWSQDGVSL GKFCGETVPK PVKSTGNRMT VRFKSDNSVN KIGFAATFEK
     EYDECMALHG GQQHGCQHIC VNTLGGYHCD CRPGFHLHRD GRTCEDTCGG TLYPPNKHCK
     WHIIAPIGHK ILLNFTTFDI EGRDVSLAWP LSSGHVTHPA LIKSHPLPGH RAPVTSGHVT
     HLLSLISCPC PAHRAAGHVT HLLSLISSPA PGTELRSRDA PALINLIPCP ATELRSRDAP
     ALINLIPCRP PSSGHVTHLL SLISSPARAP SSTVTPALIN LSPARAPSSG HVTPALINLI
     PCPGTELRSR DAPAALINHP LARQPSSGHR CEYDYLDIFD GVDEATSKRV GRYCGDQPPS
     VQGGFSASFM VDRDECAMMN GGCDQLCKEH HRLPTGYVLY GNHQCKEGGC KHRITRLSGE
     FSSPNYPRRY PLEKRCSWNF LTTPGHRNQT GVQALRDPSS HPQVFKHFEI ERHPDCAYDH
     VEIRDGPDAT SERIGVFCGD AMPPTPVIST GNSMFVGFVS DSSLQRKGFN ADHSSICGQS
     ASPRPRERER LLQPRRLRGQ GLRDRENCNW TLTTSNPEEV IVLNMETFEL ESEIECGYDY
     VDIFDDDNDR GVLLAATAAT CGREERIPYK VFPSTDSSAK VFPQYGFPVK CFPGPDGPIY
     SSRQSLHIRF RSDDTISFKG FHAVCTARCE PGGAAAPRAH RGGIIPRTDG PQTAC
//