ID A0A1I8JSF1_9PLAT Unreviewed; 1841 AA.
AC A0A1I8JSF1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Dual serine/threonine and tyrosine protein kinase {ECO:0000256|ARBA:ARBA00040421};
DE EC=2.7.12.1 {ECO:0000256|ARBA:ARBA00013203};
DE AltName: Full=Dusty protein kinase {ECO:0000256|ARBA:ARBA00042638};
DE AltName: Full=Receptor-interacting serine/threonine-protein kinase 5 {ECO:0000256|ARBA:ARBA00041268};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:snap_masked-unitig_5529-processed-gene-0.0-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:snap_masked-unitig_5529-processed-gene-0.0-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000972};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.12.1; Evidence={ECO:0000256|ARBA:ARBA00001076};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001687};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR WBParaSite; snap_masked-unitig_5529-processed-gene-0.0-mRNA-1; snap_masked-unitig_5529-processed-gene-0.0-mRNA-1; snap_masked-unitig_5529-processed-gene-0.0.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00180; PKc; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR46392; DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE; 1.
DR PANTHER; PTHR46392:SF1; DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE; 1.
DR Pfam; PF00350; Dynamin_N; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 979..1281
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 1841 AA; 205098 MW; 231FE8D31B541117 CRC64;
MSGFLSAKNR PACLNSSSRF FSTMLLDCCI DCPTVVPHCK CQFIDRIMPV CNGTHGNGDA
RVRVDDRVQR RVLVQSWRVD DVDAVSQELA LDAGLDSRAD ELIILAVLVL QLDEVLLDCR
LLEVLDVSDL LAGLGSHEHV DSVGVEVKQL LTKQFIDEGA LARLGLANND DARLAAVTGT
RLVAPVQLVD LLPHGDSCNF AENSGDKALE KLSVNSLCVV SRCSLIRSRL LRNSAISSSR
KPLGCASACE MAMAAFLQLQ VSRERHLLSA TCNCFRSSGS SGWLNTAAIS LFRWQSVSRQ
EPGSVNRCLE KLFKSCSLGK KFVIRAAAEV KMAQASSNAV QEDRDFLSRE IKRFYANRDQ
LRKTLQETQE FVETRFAQNL SAEFSSLVMQ NLQLDSVWQL VNRLFNGHRG GSDGSSRPCI
IIAGQTKSGK SSFINELLGG TFVAQSQSPC TARVTRLTYS DRIYVLVRSK TGEQIGDVQY
LEKPTIEEDL VKLKDEDREN DELISSTVEA GIKCEFLRHG IDIIDSPGLN ENSSLDSLTL
GAIDSFLPII IYVIDSNSGV TVAMDVADHL AAEMGREVAE MEAEKADHVF SKLQRLGYIS
KDATRQSCRK FLCVSCWEVR RFRRKKEMIE KKMKKSKTAE SGEKLMSDLV KEMENSKWVR
QFEEVKRRIL QFAQDQFKNL IVGAGSSLRA VHCQILTMFM DKAHDIKESN QRKKKALYQI
KSLEHEIHQQ SKSIVERHRG EFLAQANRFF AEKKPLILDE VRSMSYSDSV ISEGMSQRDI
EKKCIEEIHT LINDRIIATF SDFLRDNVLR TCFTDFDDLK EKVAEYEKDV EQTPAYQVLK
KTLLEGYSLS SKAIVRGSVT CFIRNIGSTL RALLKHPDIF LGKAVQHHKW KEHQASQYLK
NIDREKLVAC LVSSIGEWFD KRHSDFLHSM SYSEVLVEKS YRMTDRERKE IIKLSPIVAL
LHMNAFAIIT RYKFRNHRLD LDNCLGSGAQ GRVYTVLSPT GEPVMAAKKI VTNRAGLEEI
AAEAYYSSVL EHPNIVRVVG TVLLENAKHN GQWSVELYME LMHCDALTLM EQQRLSLAKR
LWLGLQISKA LEFLHSSQLI HRDVKLANLL VNSEATVAKL SDFGLLKGQG LVGHTLVGTP
IYLSPELVRR ENYGVSTDIF SLGIALWYLV EGSGQHHPDY VTNLKTVEEV LAATSERGCR
PNRLPEASDQ AVAAHGPLLG RDAGQATDSW ASFGQPGGYH KSTGSWPIDK QQMAQLSNYL
DQFLLNRQRL ANALDEVRCL VEEARQIVAA TSAERLEAVA SEVEKLLRLR GRRGRQGDAE
CRVCLLIVGQ TKAGKSSFIN ELLGQQVLAQ SQHPCTSQVV RIVHSAEPFD SPIEDPEANG
ELSPAVIGRP SEFLLASGLD LVDTPGLNEN ARLDELTLSA VDAFLPLVVY VINANNGVSR
MTRVGGPDKL FYLATHMDID DGDISAGCGR TRETLEREKL QRLLAGLRRL GCIIEPESGK
PVDYGKNQYH NQHSSQQVSE PPCSDRFCCI SSRIVATVRR RHRRQQLRMK QLTIASDDEA
RWLEAFQLAK SSLSSFAKRR LTELPLEAAT SLRRALLDYL HKDLDEAASL ASEEACHRRR
LTLLDAGHAA VCLLADSESA ASGAATARNL VRWLTAALKQ RCSELAKASA GAAESPSRLE
LLDILTDRIG GDFDFALPRL ADCFQRGVSL AKQVEEAAGG EGPQKLKDSV CRSGACGRQL
AELLLDDGCK PPKGLSRLRL RPKVPSRDAD LRRLNVEEFL GKLKLNKLAD GVLQDLRRWF
EELHRGILAA VQAAEDRVQL DLRTAMDRRR SLSLALAAAY A
//