ID   A0A1I8JUV4_ANOFN        Unreviewed;       612 AA.
AC   A0A1I8JUV4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
OS   Anopheles funestus (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN016223-PA, ECO:0000313|Proteomes:UP000075900};
RN   [1] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA   Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA   Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA   Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT   "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT   Middle East: occurrence data, distribution maps and bionomic precis.";
RL   Parasit. Vectors 3:117-117(2010).
RN   [2] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA   Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA   Besansky N.J.;
RT   "A chromosome-scale assembly of the major African malaria vector Anopheles
RT   funestus.";
RL   Gigascience 8:0-0(2019).
RN   [3] {ECO:0000313|EnsemblMetazoa:AFUN016223-PA}
RP   IDENTIFICATION.
RC   STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN016223-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the INTS14 family.
CC       {ECO:0000256|ARBA:ARBA00007451}.
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DR   AlphaFoldDB; A0A1I8JUV4; -.
DR   STRING; 62324.A0A1I8JUV4; -.
DR   EnsemblMetazoa; AFUN016223-RA; AFUN016223-PA; AFUN016223.
DR   VEuPathDB; VectorBase:AFUN016223; -.
DR   VEuPathDB; VectorBase:AFUN2_001295; -.
DR   OrthoDB; 3673014at2759; -.
DR   Proteomes; UP000075900; Unassembled WGS sequence.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR039841; INTS14.
DR   InterPro; IPR045814; IntS14_b-barrel.
DR   InterPro; IPR046471; IntS14_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR   PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR   Pfam; PF19435; IntS14_b-barrel; 2.
DR   Pfam; PF20504; IntS14_C; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          3..127
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|Pfam:PF13519"
FT   DOMAIN          277..359
FT                   /note="Integrator complex subunit 14 beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF19435"
FT   DOMAIN          410..466
FT                   /note="Integrator complex subunit 14 beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF19435"
FT   DOMAIN          507..609
FT                   /note="Integrator complex subunit 14 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20504"
FT   REGION          360..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..375
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   612 AA;  67442 MW;  58CBB61D31D70D7D CRC64;
     MPTIIALDVS LSMSRPIPNQ PSSTGGSGST ESDNVLTYHH LAVQGINYVL DYLTKHARLE
     YVSLIIYSSL YEVVVDFTRD YDTIRNALHK IEHYDKTCLE NVLVAVNNAF KAHWGSQNYC
     QIIFITDCGV GMGPSSLKNT IINIQTYKAT CAAAAAAAAT TDGTKTTVTV GSNSAAIPPP
     GENQWVGFSY PSKLSFMCLG SLSTDSAFRC GTKLYMQLLE VSGQKGQLFI PRMKMKHEES
     GGDEPSPTTG EDGEDFVRQL TRASALESFA SMCDTNYRQF EATLRCGGYF RLEEPITVWP
     APLPYTARDV LGAETTKLMS RRLEVCGFLR MSDIGSPMSV SRHLILPRSV GGLTVGISEQ
     NEGGKASTNG GLKNGHGHSS AEERLEADIK AFYAKSDAGD HHPHEDHGLD GTDVNKESVC
     VLLHGSLKVE NMAALVHVGD NWYGFIYSYA DGKKKWNLML NVLPPGSDVV PWLGDLRYLG
     TLEDAFQGEN PSFPIKADKR SYSQTIVVWI RHASLQSDIQ KVLRHAKKLP EKTQHFYKEL
     NRIRRAALSL GFVELLEGLA HIFEREISTL PLNASPDCSM QLTHAAIELR KTNNRDLKSI
     IHALPTQYNQ LA
//