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Database: UniProt
Entry: A0A1I8M183_MUSDO
LinkDB: A0A1I8M183_MUSDO
Original site: A0A1I8M183_MUSDO 
ID   A0A1I8M183_MUSDO        Unreviewed;      1390 AA.
AC   A0A1I8M183;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=Tight junction protein ZO-2 isoform X5 {ECO:0000313|RefSeq:XP_011294538.1};
GN   Name=101889943 {ECO:0000313|EnsemblMetazoa:MDOA000217-PH};
GN   Synonyms=LOC101889943 {ECO:0000313|RefSeq:XP_011294538.1};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA000217-PH};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA000217-PH}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA000217-PH};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_011294538.1}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|RefSeq:XP_011294538.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
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DR   RefSeq; XP_011294538.1; XM_011296236.2.
DR   EnsemblMetazoa; MDOA000217-RH; MDOA000217-PH; MDOA000217.
DR   VEuPathDB; VectorBase:MDOA000217; -.
DR   OrthoDB; 2904077at2759; -.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   Proteomes; UP000694905; Unplaced.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   CDD; cd11859; SH3_ZO; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR13865:SF28; POLYCHAETOID, ISOFORM O; 1.
DR   PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF00595; PDZ; 2.
DR   Pfam; PF07653; SH3_2; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
PE   4: Predicted;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW   Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT   DOMAIN          22..109
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          183..265
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          430..503
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          691..792
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          313..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          826..981
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1005..1073
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1086..1357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        826..863
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        885..936
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        956..980
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1005..1019
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1044..1073
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1188..1202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1237..1251
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1254..1275
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1291..1318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1326..1342
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1390 AA;  151972 MW;  4DF663122750A207 CRC64;
     MKFPEYVPNN ILGDRTTWEY HTVSVTRVPG YGFGIAVSGG RDNPHFANGD PSIAVSDVLK
     GGPAEDRLQV NDRIISVNGV SLENVEYATA VQVLRDSGNT VTLVVKRRVP LNTVIANQQQ
     QQQQQQMQHQ QQQHNMNGLN SMPQTNGINS MVVPPNPTAM SQPNSLNSSL VQATGPGMGQ
     PIKVTLTKNS KKEDFGIVLG CRLFVKEISS KARDQLAANG YSLQEGDIIT RIHNTNCADT
     MSLKEAKKII DGCKERLNLV ALRDITNQPP ITVVNQLNNS SATQANIYGT HQPQLSNCSN
     NLDDPYLNGG ATYSSQNLYV QPPTRTPNNG PMNGLMDEKS NLTPRGRSRG PIMEGVSLQQ
     LDRPVTPTNG QGGRSRIDEP PRPPPPRAGG GGPAVNGGED FYSSRRQLYE DDPLTRSRQS
     SEPRFISFQK EGSVGIRLTG GNEAGIFVTA VQPGSPASLQ GLTPGDKILK VNDMDMLGVT
     REEAVLFLLS LQDRIDLIVQ YCKEEYDEVV NNQRGDSFHI KTHFHCDNPS KGEMAFKAGD
     VFRVIDTLHN GVVGSWQVLK IGRGHQEMQR GVIPNKSRAE ELATAQFNAT KKEMNASESR
     GNFFRRRRST HRRSKSLSRE NWDDVVFSDS ISKFPAYERV VLRHPGFVRP VVIFGPIADL
     AREKLAKDYP DKFCTPLQDD DKTTNSKCRI VRLSNIRDVM DRGKHALLDI TPNAVDRLNY
     AQFYPIVIFQ KTDSKHVIKQ LRQGMPKSAH KSSKKLLEQC QKLERVWSHI FSTHIVLNDE
     ESWYRKLRDA IDLQQSGAVW MSETKPVESL SDDFLFPMTS NRLSYASSPE SDLELSPGPS
     TSLSLGNLPQ LVKSNSDPSI ATNQDNLDRD RDIIGEGLPP PYTIPFDHSN TTTTTQPPPS
     RRQTMDTSKY GGYSSNSNLL NSSDPSTPST RPQSLYGINA PDLPPRIDRQ SKPGPNDIVV
     TPSSTNTPSR SNSSGGTLGR SAQERLFGKA IVSDDVQAEY ISRNAANALQ ANQPPPTGAD
     PTTMDRHHAS LERQARLNAA AQSKIPGAPT SATASAISTP QQQNGSSYDS VSSYDSYNAS
     QLTMQNLGRL GPNAPDDLKS VPNVNAGRPL PPVGMAGQTA DYARTTHDHR QYGGGPNDLN
     RQSSPGRPPY HDMNAARNID PRNGTPQRPS NLGLEGSPRK VETKTDYGKY SRNNSASQAD
     YNKIPKNPGM PHMVIPPPNV NGNMNGSSAG PQAAASGPFK PVPPPKPKNY RPPLQNAGNG
     NGPNQWENQE PGSPRSPNGF YYPPAPQHHH YGQQTPGSPH ANANMQPTYG TNNNYGPPPN
     ATGYPPANGY NGNATTHHYN GGSGTGPYIA PHRGMPPPID LAGSREQRGS AFELYRKPQI
     GTAGHHHNMR
//
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