ID A0A1I8M183_MUSDO Unreviewed; 1390 AA.
AC A0A1I8M183;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Tight junction protein ZO-2 isoform X5 {ECO:0000313|RefSeq:XP_011294538.1};
GN Name=101889943 {ECO:0000313|EnsemblMetazoa:MDOA000217-PH};
GN Synonyms=LOC101889943 {ECO:0000313|RefSeq:XP_011294538.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA000217-PH};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA000217-PH}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA000217-PH};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_011294538.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_011294538.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_011294538.1; XM_011296236.2.
DR EnsemblMetazoa; MDOA000217-RH; MDOA000217-PH; MDOA000217.
DR VEuPathDB; VectorBase:MDOA000217; -.
DR OrthoDB; 2904077at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd11859; SH3_ZO; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR13865:SF28; POLYCHAETOID, ISOFORM O; 1.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 22..109
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 183..265
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 430..503
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 691..792
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 313..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1251
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1390 AA; 151972 MW; 4DF663122750A207 CRC64;
MKFPEYVPNN ILGDRTTWEY HTVSVTRVPG YGFGIAVSGG RDNPHFANGD PSIAVSDVLK
GGPAEDRLQV NDRIISVNGV SLENVEYATA VQVLRDSGNT VTLVVKRRVP LNTVIANQQQ
QQQQQQMQHQ QQQHNMNGLN SMPQTNGINS MVVPPNPTAM SQPNSLNSSL VQATGPGMGQ
PIKVTLTKNS KKEDFGIVLG CRLFVKEISS KARDQLAANG YSLQEGDIIT RIHNTNCADT
MSLKEAKKII DGCKERLNLV ALRDITNQPP ITVVNQLNNS SATQANIYGT HQPQLSNCSN
NLDDPYLNGG ATYSSQNLYV QPPTRTPNNG PMNGLMDEKS NLTPRGRSRG PIMEGVSLQQ
LDRPVTPTNG QGGRSRIDEP PRPPPPRAGG GGPAVNGGED FYSSRRQLYE DDPLTRSRQS
SEPRFISFQK EGSVGIRLTG GNEAGIFVTA VQPGSPASLQ GLTPGDKILK VNDMDMLGVT
REEAVLFLLS LQDRIDLIVQ YCKEEYDEVV NNQRGDSFHI KTHFHCDNPS KGEMAFKAGD
VFRVIDTLHN GVVGSWQVLK IGRGHQEMQR GVIPNKSRAE ELATAQFNAT KKEMNASESR
GNFFRRRRST HRRSKSLSRE NWDDVVFSDS ISKFPAYERV VLRHPGFVRP VVIFGPIADL
AREKLAKDYP DKFCTPLQDD DKTTNSKCRI VRLSNIRDVM DRGKHALLDI TPNAVDRLNY
AQFYPIVIFQ KTDSKHVIKQ LRQGMPKSAH KSSKKLLEQC QKLERVWSHI FSTHIVLNDE
ESWYRKLRDA IDLQQSGAVW MSETKPVESL SDDFLFPMTS NRLSYASSPE SDLELSPGPS
TSLSLGNLPQ LVKSNSDPSI ATNQDNLDRD RDIIGEGLPP PYTIPFDHSN TTTTTQPPPS
RRQTMDTSKY GGYSSNSNLL NSSDPSTPST RPQSLYGINA PDLPPRIDRQ SKPGPNDIVV
TPSSTNTPSR SNSSGGTLGR SAQERLFGKA IVSDDVQAEY ISRNAANALQ ANQPPPTGAD
PTTMDRHHAS LERQARLNAA AQSKIPGAPT SATASAISTP QQQNGSSYDS VSSYDSYNAS
QLTMQNLGRL GPNAPDDLKS VPNVNAGRPL PPVGMAGQTA DYARTTHDHR QYGGGPNDLN
RQSSPGRPPY HDMNAARNID PRNGTPQRPS NLGLEGSPRK VETKTDYGKY SRNNSASQAD
YNKIPKNPGM PHMVIPPPNV NGNMNGSSAG PQAAASGPFK PVPPPKPKNY RPPLQNAGNG
NGPNQWENQE PGSPRSPNGF YYPPAPQHHH YGQQTPGSPH ANANMQPTYG TNNNYGPPPN
ATGYPPANGY NGNATTHHYN GGSGTGPYIA PHRGMPPPID LAGSREQRGS AFELYRKPQI
GTAGHHHNMR
//