ID A0A1I8M280_MUSDO Unreviewed; 778 AA.
AC A0A1I8M280;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA000498-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA000498-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA000498-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR AlphaFoldDB; A0A1I8M280; -.
DR STRING; 7370.A0A1I8M280; -.
DR EnsemblMetazoa; MDOA000498-RA; MDOA000498-PA; MDOA000498.
DR VEuPathDB; VectorBase:MDOA000498; -.
DR eggNOG; KOG2166; Eukaryota.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 383..647
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 778 AA; 90130 MW; C1FAF6C079F7BEAA CRC64;
MNIRSNAPKK EGKMRIRAFP ASMDEKYVET IWASLKNAIQ EIQKKNNSGL SFEQLYRNAY
NMVLHKHGHR LYFGLRDVVK EHLEEKVRKD VLESLHNNFL PKLNQAWTDH QTSMVMIRDI
LMYMDRVYVQ NRDVENVYNL GLILFRDEIV RYSEIQKALR ETLLNMVMSE RSGEAINHLA
IKNACQMLMA LGINSRSVYE EDFEKPFLAQ SASFYKFESQ KFLAENNASV YLRKVEQRIL
EESSRAALYL DKDTEPRIVK VVEDELIKKH MRTIVEMENS GVVYMIKNSK TEDLACTYKL
FSRLKDEGMK VIADTMSAYL REQGRMLVKE EENGNTNPIT FVQNLLDLKD RFDQFLHHSF
NNDRLFKNVI SSDFEHFLNL NSKSPEYLSL FIDDKLKKGG KGMSEQEIEV ILDKTMVLFR
FLLEKDVFER YYKTHLAKRL LLNKSVSDDF EKNMISKLKT ECGCQFTSKL EGMFKDMSIS
NTTNDEFKTY IANHNINLSV EFTCRILTTG FWPTQTSTPN CNIPAAPREA YEIFKKFYLD
KHSGRQLTLQ PQLGNACLNA VFYGRKPTDN ANAAADKDAP SSSMSSSTSA TACAIPTTTR
KHILTVSTYQ MCILMLFNNR EVMTHEEILQ ETDIPERELQ RAIQSLSMGK PSQRLLVRNS
KTKTKDIDPT DEFLVNDALN SRVKIQTVAA KADTEPERKE TRGKVDEDRK HEIEAAIVRI
MKARKRIPHN LLVSDVTSQL KSRFLPSPVL IKKRIEGLIE REYLARTPDD RKVYVYLA
//