ID   A0A1I8M280_MUSDO        Unreviewed;       778 AA.
AC   A0A1I8M280;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA000498-PA};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA000498-PA}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA000498-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   AlphaFoldDB; A0A1I8M280; -.
DR   STRING; 7370.A0A1I8M280; -.
DR   EnsemblMetazoa; MDOA000498-RA; MDOA000498-PA; MDOA000498.
DR   VEuPathDB; VectorBase:MDOA000498; -.
DR   eggNOG; KOG2166; Eukaryota.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          383..647
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   778 AA;  90130 MW;  C1FAF6C079F7BEAA CRC64;
     MNIRSNAPKK EGKMRIRAFP ASMDEKYVET IWASLKNAIQ EIQKKNNSGL SFEQLYRNAY
     NMVLHKHGHR LYFGLRDVVK EHLEEKVRKD VLESLHNNFL PKLNQAWTDH QTSMVMIRDI
     LMYMDRVYVQ NRDVENVYNL GLILFRDEIV RYSEIQKALR ETLLNMVMSE RSGEAINHLA
     IKNACQMLMA LGINSRSVYE EDFEKPFLAQ SASFYKFESQ KFLAENNASV YLRKVEQRIL
     EESSRAALYL DKDTEPRIVK VVEDELIKKH MRTIVEMENS GVVYMIKNSK TEDLACTYKL
     FSRLKDEGMK VIADTMSAYL REQGRMLVKE EENGNTNPIT FVQNLLDLKD RFDQFLHHSF
     NNDRLFKNVI SSDFEHFLNL NSKSPEYLSL FIDDKLKKGG KGMSEQEIEV ILDKTMVLFR
     FLLEKDVFER YYKTHLAKRL LLNKSVSDDF EKNMISKLKT ECGCQFTSKL EGMFKDMSIS
     NTTNDEFKTY IANHNINLSV EFTCRILTTG FWPTQTSTPN CNIPAAPREA YEIFKKFYLD
     KHSGRQLTLQ PQLGNACLNA VFYGRKPTDN ANAAADKDAP SSSMSSSTSA TACAIPTTTR
     KHILTVSTYQ MCILMLFNNR EVMTHEEILQ ETDIPERELQ RAIQSLSMGK PSQRLLVRNS
     KTKTKDIDPT DEFLVNDALN SRVKIQTVAA KADTEPERKE TRGKVDEDRK HEIEAAIVRI
     MKARKRIPHN LLVSDVTSQL KSRFLPSPVL IKKRIEGLIE REYLARTPDD RKVYVYLA
//