ID A0A1I8M339_MUSDO Unreviewed; 561 AA.
AC A0A1I8M339;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Pickpocket protein 28-like {ECO:0000313|RefSeq:XP_005176879.1};
GN Name=101887721 {ECO:0000313|EnsemblMetazoa:MDOA000753-PA};
GN Synonyms=LOC101887721 {ECO:0000313|RefSeq:XP_005176879.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA000753-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA000753-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA000753-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005176879.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005176879.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC ECO:0000256|RuleBase:RU000679}.
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DR RefSeq; XP_005176879.1; XM_005176822.2.
DR EnsemblMetazoa; MDOA000753-RA; MDOA000753-PA; MDOA000753.
DR GeneID; 101887721; -.
DR KEGG; mde:101887721; -.
DR VEuPathDB; VectorBase:MDOA000753; -.
DR eggNOG; KOG4294; Eukaryota.
DR OrthoDB; 3414706at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 67..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 64860 MW; C0AA38C8DDFEB91C CRC64;
MTISLQRQKE NIDETGSHDS AIGSEQSPRN KSKSLKKNLK EIYHEFCSNT SIHGFQYFGQ
QRPRKEIIFW IIIFIITLYF CISIIVKIYV KWHETPVIVT FSEESTPVWN IPFPRLTICP
ETKRELKVND SNYFELIQTL GSYIDQETKE FSTNFTRSEH EDTLTLMHVC QTGIEGILSI
PKSNDTTTID YVQNLNNMLP GFEKYFFTCQ WFGQKMPCKE LLRKVYTDEG ICYAFNSLKA
HDLYRDEVMR SQMREERANK SEDALAWSLE KGYAPGSDIH TYPMRVLSSG STAGFQIFLQ
SFANETDFTC TGPTQGFKIM LNSPDDVPSV EKHFVRVSMD KEIMVAVKPT MITTSSNIEA
YRPEKRRCYL KQDRQLRFYK IYTQRNCERE CVTNFTYHEC GCVKFSMPRT ADMPICGEDK
LMCYKGARDR LLLQQFKEGL SHSQSASGCN CMPGCTSLEY ETEISEGSFD LENTLRAFDN
YDDYFALYPG GRMSLVTIYF KDNQFITSRR SELYGVTELM ANFGGVLGLF MGVSLLSVVE
IIYHCSLRLW SNMRRGEGKE N
//
