ID A0A1I8M3U7_MUSDO Unreviewed; 1126 AA.
AC A0A1I8M3U7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Integrin alpha-PS3 isoform X1 {ECO:0000313|RefSeq:XP_005192056.1};
GN Name=101890688 {ECO:0000313|EnsemblMetazoa:MDOA000979-PB};
GN Synonyms=LOC101890688 {ECO:0000313|RefSeq:XP_005192056.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA000979-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA000979-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA000979-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005192056.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005192056.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_005192056.1; XM_005191999.3.
DR STRING; 7370.A0A1I8M3U7; -.
DR EnsemblMetazoa; MDOA000979-RB; MDOA000979-PB; MDOA000979.
DR GeneID; 101890688; -.
DR KEGG; mde:101890688; -.
DR VEuPathDB; VectorBase:MDOA000979; -.
DR eggNOG; KOG3637; Eukaryota.
DR OrthoDB; 4246085at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF83; INTEGRIN ALPHA-PS3-RELATED; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 6.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1066..1088
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 52..111
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 126..187
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 340..401
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 402..458
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 465..527
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 513..649
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 652..770
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
SQ SEQUENCE 1126 AA; 125915 MW; B3466599314D668C CRC64;
MKKLKMLTLT CYRLRLIGPL SVFLTLILCN IISVSECYNL SPIPNAVIRE PQLPTFIPKY
ESSYFGFTLS LRKLGLIIGA PRAQSTLESQ RKINETGAVY RCTINGTPQC APFVFENRGN
INIEDSDYTY DSEQRDFQWM GAAMDGGTKD TDKLIVCAPR FITPTVFEYM MHGKCYWIND
TLSATPQNVR SISPLRAKID QIVDDDGERN YYYMLAEQGL SVHVTADNDQ FLIGAPGIHK
WRGSVIRYRK REYIDEPSLS RRDTSSVSRV ARQIRVSYET DIPKPRNFNQ ASDSYFGYSV
DSGYFDSNNP QKLLYVASAP QADEQSGEAY IFDYPSKYKI TKHFVFRGKQ FGEYFGYAVL
AEDINGDNLT DVIVSAPQHT ITGSYDDGAI YVFINQGNLY FERKLITSPF HGKGRFGTTL
TKLGDINFDG YNDIAVGAPF AGNGSVFVYM GSKRGLREQP TQRLDYPGTE QLTYGSAMFG
HGLSKGSDVD DNGYNDFAIG APNAETVYLY HAYPVVSIKA TVSSQTREIS HDQTTFPVTI
CYSIATNSRT VQSQDLALNF VVDPQVKRVR IISTNTNELQ FNVTATSTTQ CKVVDCNVRY
SVSDIFKPIE LELHYQLVHA IPDSEVFCTT CAAVDPAEPK ISTEKIIFNT GCNTDICVAD
LQMTARLDRT FILGSSPTFK VSYDVVNRGE TAYLPQINIT SSNRMLFAKI PSNCKHNVQD
SMLLCDLNRG HHMANGTSDT ITVIYDTSNI SGEKMVLMAK VFSTGNEKTP GDNIASDVIT
LTEFTEISAV GVPQSKHINL EEVSNSAEIV NVYEIKSNGP STVSSMQLVF DIPVAYTIPG
TTKTIPIIDM NNITMQAMYD SQIKDVSFYL NNTQILMNAV EKMSSFSTQF NTKVITESGS
SHFRTVEMHS SGEFTVKEES FGDSILTSLA RRRRRREAAA LTANKDQYAR IAHSKSFELL
GEDLKGTLPV NRTIVFNCND PEMTQCVRAV IPLYDFKRNK PITVTMKYHV DLKEVNEILI
EPWEFFVIVI DVDVQKTNDP TGSTLAISKK IEYNIISKHQ LYGTPIWAII LAIIGGLLAL
ALITYGMYKA GFFKRAKKEE MDKLVHQAQL SNDGVTETSN LNTEDN
//
