ID A0A1I8M3W7_MUSDO Unreviewed; 1438 AA.
AC A0A1I8M3W7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN Name=101887261 {ECO:0000313|EnsemblMetazoa:MDOA000996-PA};
GN Synonyms=LOC101887261 {ECO:0000313|RefSeq:XP_005174763.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA000996-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA000996-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA000996-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005174763.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
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DR RefSeq; XP_005174763.1; XM_005174706.3.
DR STRING; 7370.A0A1I8M3W7; -.
DR EnsemblMetazoa; MDOA000996-RA; MDOA000996-PA; MDOA000996.
DR GeneID; 101887261; -.
DR KEGG; mde:101887261; -.
DR VEuPathDB; VectorBase:MDOA000996; -.
DR eggNOG; KOG1025; Eukaryota.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR CDD; cd00064; FU; 7.
DR CDD; cd05057; PTKc_EGFR_like; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF566; EPIDERMAL GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 7.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|PIRNR:PIRNR000619,
KW ECO:0000313|RefSeq:XP_005174763.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000619}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1438
FT /note="Receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041080390"
FT TRANSMEM 880..904
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1012..1031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 396..427
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 950..1210
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 32..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1247..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1396..1438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1419..1438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1075
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT BINDING 956..964
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 983
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1438 AA; 160456 MW; 7B96397651376409 CRC64;
MKGYNWLGAS LLLLIVLTHN FEPLLAQRAR NGRNSNKYNE DTNNNRSQRK RNNNNGNRSQ
SSHRPRPSSQ HLISSLAAPS SLSSSSISGS SSSSTHHHLA EDQHTEFVKG KICIGTKSRL
SVPSNREHHY RNLRDRYNNC TYVDGNLELT WLQDANLDLS FLENIREVTG YILISHVDIR
QVVFPRLQII RGRTLFNLNV QDEQFALFVT YSKTFSLEMP ALRDILQGSV GFFNNFNLCH
IKTLDWNEII SGPPDKYKYH YVYNFTVPER QCPKCHESCE GGCWGEGPNN CQKFSKINCS
PQCAQGRCFG PRPRECCHLF CAGGCTGPTQ RECIACKNFY DDGVCKEECP PMQKYNPTNY
LWEANPEGKY AYGATCVKEC PEHLLKDNGA CVRSCPAFKM AKDGECIPCN GPCPKTCPGR
AVLHSGNIDS YKGCTVIEGS IRVLDQTFSG YQDIYKNYSL GPRYIAMHPD RMEVFSTVKE
ITGYLDIEGV HPDFKNLSYF RNLEVIHGRQ LMESYFASLS IVKSSLQSLE LKSLKRINAG
SVVIQHNDKI CYVNDIDWSK LQKSGEHGFV VEMNRNKEDC KKNGLVCSDQ CNSSGCWGSG
PDQCLECKNF EFNGTCIADC RNITNAYQFD AKTCKQCHPE CRTCSGPDAE HCDECVHVRD
ENRCVTVCPE NKFSDYGVCR TCHATCEGCT GPNNTIGPGG CKTCNLAIIN SDGDIERCLL
KNDKCPDGYY WEYVNPREQG KLRPLAGKAI CRKCHPRCEL CSGYGFHEQV CQKCAGYKRG
EQCDDECPTD HYADEVNREC FMCHPECKGC IGPGADECLA CRSFKIFGDG DPYDNSTVFN
CTSKCPPELS HVIYQAPHLG TYCSSVPMKG SKLVAAVDNY IFLVIAVVAL VVVLGTLSVV
TYVCRQKTKA KTEAVKMTMV LSGCEDSEPL RPSNIGANLS KLRIVKEAEL RKGGVLGMGA
FGRVFKGVWV PEGENVKIPV AIKELLKSSG AESSEEFLRE AYIMASVEHP NLLKLLAVCL
TSQMMLITQL MPLGCLLDYV RNNRDKIGSK ALLNWSTQIA KGMSYLEEKR LVHRDLAARN
VLVQTPSCVK ITDFGLAKLL NNDSNEYKAA GGKMPIKWLA LECIRHRVFT SKSDVWAFGV
TIWELLTFGQ RPHENIPAKD IPDLIEVGLK LEQPEICSLD IYCTLLSCWH LDAEMRPSFK
QLVNVFAEFA RDPGRYLAIP GDKFTRLPAY TSQDEKDLIR KLAPSFEGSE GMAEPDDYLQ
PKAAPGNHNQ EGSEDVPKLN RYCKDPMNKN SSNESDETDS NAREVGVGDL RLELPVDEDD
YLMPTCQISS QTTLNNNNVT TSNAMSGAPG GYMDLIGVPA SVDNPEYLLN TSANLNGQEA
PIPTQTLGIP VMVTRPPNPG PTMLDIPVTP SEPTSSDHEY YNDTQRELQP LHRNETRV
//
