ID A0A1I8M5L1_MUSDO Unreviewed; 165 AA.
AC A0A1I8M5L1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Epididymal secretory protein E1 {ECO:0000313|RefSeq:XP_005175727.2};
GN Name=101892304 {ECO:0000313|EnsemblMetazoa:MDOA001478-PA};
GN Synonyms=LOC101892304 {ECO:0000313|RefSeq:XP_005175727.2};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA001478-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA001478-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA001478-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005175727.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NPC2 family.
CC {ECO:0000256|ARBA:ARBA00006370}.
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DR RefSeq; XP_005175727.2; XM_005175670.3.
DR STRING; 7370.A0A1I8M5L1; -.
DR EnsemblMetazoa; MDOA001478-RA; MDOA001478-PA; MDOA001478.
DR VEuPathDB; VectorBase:MDOA001478; -.
DR OrthoDB; 2545683at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0032367; P:intracellular cholesterol transport; IEA:InterPro.
DR CDD; cd00916; Npc2_like; 1.
DR Gene3D; 2.60.40.770; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR003172; ML_dom.
DR InterPro; IPR033916; ML_Npc2-like.
DR InterPro; IPR039670; NPC2-like.
DR PANTHER; PTHR11306; NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED; 1.
DR PANTHER; PTHR11306:SF36; NIEMANN-PICK TYPE C-2C-RELATED; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..165
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041051704"
FT DOMAIN 21..148
FT /note="MD-2-related lipid-recognition"
FT /evidence="ECO:0000259|SMART:SM00737"
SQ SEQUENCE 165 AA; 17896 MW; DFAF484D407F4F78 CRC64;
MKFLFVIVVA LMIAGIGATN VKECKKGQPF PLSVDIVGCD EMPCNVVKGT TAVMYVHFVG
TKDNIRKLNA VVHATTLGIT VKYDLPEDVS NVCDNLMYGA TCPIDKTEDV VYAFNFYIDS
SYPEISVSVQ VSLNDEEDDS IACFVANIKV KRGSTNTPLL ENGSA
//
