ID   A0A1I8M5T7_MUSDO        Unreviewed;       815 AA.
AC   A0A1I8M5T7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN   Name=101900828 {ECO:0000313|EnsemblMetazoa:MDOA001529-PE};
GN   Synonyms=LOC101900828 {ECO:0000313|RefSeq:XP_005178976.1};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA001529-PE};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA001529-PE}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA001529-PE};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_005178976.1}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|RefSeq:XP_005178976.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|PIRNR:PIRNR001251};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
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DR   RefSeq; XP_005178976.1; XM_005178919.3.
DR   EnsemblMetazoa; MDOA001529-RE; MDOA001529-PE; MDOA001529.
DR   GeneID; 101900828; -.
DR   VEuPathDB; VectorBase:MDOA001529; -.
DR   OrthoDB; 20951at2759; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   Proteomes; UP000694905; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF0; AMP DEAMINASE; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694905}.
SQ   SEQUENCE   815 AA;  93452 MW;  E557206FB9986564 CRC64;
     MSSRGVLIAT DSMESMDIQV LDPYNVHTPK TPPLHLNISS SEDIGFPTSA PNTGNRSGSA
     TPCLLVCKCF SDLKLSKCKC QPNEGSDSPL AGAVAAGQLQ PPKTPGALDE ATVDDVLPNE
     ISAPYEVPQF PIEQIEKKLQ IQRQLNVRAM TDKHSIQGDT TDDTINVLDH DLIPNFQRVS
     ISGEDTSGVP LEDLERASTL LIQALEMRSR YMSISEQSFP TTTLRFLKTV HESDRFNKIQ
     YEDRKSIADH PIHPPTETSD PWDIEFPTDK NYSIRAIDGV YNVFLNEDSQ EPMIQNYPKL
     KDFCNDMQIM CNMIADGPLK SFCYRRLCYL SSKFQLHVLL NELRELASQK AVPHRDFYNI
     RKVDTHIHAA SCMNQKHLLR FIKKTLKNNA NEVVTVTKGQ QMTLAQVFQS MNLTTYDLTV
     DMLDVHADRN TFHRFDKFNA KYNPIGESRL REVFLKTDNY LNGKYFAQII REVAFDLEES
     KYQNAELRLS IYGKSRDEWK KLAKWAIDYN VYSTNIRWLI QIPRLYDIFK SNKLMTSFQD
     ILDNIFLPLF EATAQPSKHP ELHRFLRYVI GFDSVDDESK PENPLFDGDI TTPPKWTDDE
     NPPYAYYIYY MYANMAVLNQ FRKERGLNTF VLRPHCGEAG PVQHLVCGYL MAENISHGLL
     LRKVPVLQYL YYLSQIGIAM SPLSNNSLFL NYHRNPLPEY LARGLIVSLS TDDPLQFHFT
     KEPLMEEYSI AAQVWKLSSC DMCELARNSV LMSGFPHKMK QHWLGPNYTR EGVAGNDITR
     TNVPDIRVAY RSETLLDELS NIFKVHQHPH MEESP
//