ID   A0A1I8M6U2_MUSDO        Unreviewed;       414 AA.
AC   A0A1I8M6U2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Aminopeptidase N {ECO:0008006|Google:ProtNLM};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA001833-PA};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA001833-PA}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA001833-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M1 family.
CC       {ECO:0000256|ARBA:ARBA00010136}.
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DR   AlphaFoldDB; A0A1I8M6U2; -.
DR   STRING; 7370.A0A1I8M6U2; -.
DR   EnsemblMetazoa; MDOA001833-RA; MDOA001833-PA; MDOA001833.
DR   VEuPathDB; VectorBase:MDOA001833; -.
DR   eggNOG; KOG1046; Eukaryota.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.3480.20; -; 1.
DR   Gene3D; 2.60.40.1910; -; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   InterPro; IPR024571; ERAP1-like_C_dom.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   PANTHER; PTHR11533:SF18; FI02158P; 1.
DR   PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR   Pfam; PF11838; ERAP1_C; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT   DOMAIN          16..162
FT                   /note="Peptidase M1 membrane alanine aminopeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF01433"
FT   DOMAIN          245..406
FT                   /note="ERAP1-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11838"
SQ   SEQUENCE   414 AA;  48916 MW;  781D4F2D36833DEE CRC64;
     YVYRERELLQ PGYYHIAQEL IYQWLGSWIT PYWWDDAHVN KALASFLAAN IVFEINNGRE
     FNGKYPMTIL YSLYYEFSKR YPHSRITGMK QETTSYKTEL VMRMLNYTLG DNLFREGIRT
     FILKHQYGTF REYELWDILT KQAYLDNTLN LEYNISEIVK SWIIKDRLPV VDVKRDYVDK
     TALATQKVYL RERPHDVPER DKMLWWIPLV VVQENDINFS NTTPVKWLAN TKTQILENLP
     GDDKFVIVNP EEIGPFPVNY DVKNWNLLSN FLQTSKGLSA IPTYTRAKLL HDAWNLAYAG
     DLNFASALNM TLFMKLERNH IVWNPVFTFI DHIGRHIDNS NIQEKFQNYV IHLLTPLYLE
     MNETTITDEA MFDLKSMAET FLCRAGYKPC VQEAREAFKL WMDSPNPDEQ IMAP
//