ID A0A1I8M727_MUSDO Unreviewed; 704 AA.
AC A0A1I8M727;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=101893791 {ECO:0000313|EnsemblMetazoa:MDOA001921-PA};
GN Synonyms=LOC101893791 {ECO:0000313|RefSeq:XP_005177981.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA001921-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA001921-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA001921-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005177981.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005177981.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR RefSeq; XP_005177981.1; XM_005177924.2.
DR EnsemblMetazoa; MDOA001921-RA; MDOA001921-PA; MDOA001921.
DR GeneID; 101893791; -.
DR KEGG; mde:101893791; -.
DR VEuPathDB; VectorBase:MDOA001921; -.
DR eggNOG; KOG1023; Eukaryota.
DR OrthoDB; 1356373at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR013587; Nitrate/nitrite_sensing.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF504; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF08376; NIT; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 490..619
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 704 AA; 78993 MW; A43CF2D1A9DC2F75 CRC64;
MLNGRPGDFS AGRVAVMPAK KSLAKRPQTQ TLSTVNNASA RKAKDVIAMG EPVTVAVVQA
SDNQKLQFDK MSIHSVSSED ISASNGGQCC SAAARNPAIK TGRRIQLMQM IILPFIPILA
LIVQTSISLH DVLEYRAEVA DIETQVTIAT DLGKVVTHLQ LERSEVAFYI FTNGSKVRSN
LTQRFAVTDQ ALNNMTTWSE VSVPTRDDDD DYGVLLNRSE FQSRLNEFRD RVRTEPEDNS
ITDVMNWYTA INKALLYHLS EQIKEADNSG VWRYLVGFKN LLKSIESQNI ASSFGIKYYG
RGLLGSEGFA SFIRHEFLAR ELINSTLNYV PSLRKMYLNI TETNTYKKMK NMSTVVLKNK
RRNVSDIQSA IEYYDAMHNY TDDLRILQKD LRQQIKKYVG ETLKVAAKNE AIGISILVVV
LCVSPIIIVL VKNAAATIQM YALNLAEKAK ELKREKRKSD SLLFQMLPPS VAMQLKQTQQ
VPAELYESAT VYFSDIVGFT EIAARCTPLE VVTFLNSIYR VFDERIECYD VYKVETIGDS
YMVASGLPVK NGNKHITEIA TMALDLLDAS SCFKIPRSMD ILQIRCGVHT GPVVAGIVGT
KMPRYCLFGD TVNTASRMES TGEAHKIHIT EEMNEALMRV GGFKTEHRGW IDVKGKGLMS
TYWLTCKDGP VKVREEIAWF ADMQPVFLEN LKLDPAYRSS KLKK
//