ID A0A1I8M7D6_MUSDO Unreviewed; 4612 AA.
AC A0A1I8M7D6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA002010-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA002010-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA002010-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 7370.A0A1I8M7D6; -.
DR EnsemblMetazoa; MDOA002010-RA; MDOA002010-PA; MDOA002010.
DR VEuPathDB; VectorBase:MDOA002010; -.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 2020..2167
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2302..2431
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2655..2828
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 4612 AA; 529182 MW; 4DF0ADD2748087DD CRC64;
MFVHKNTRAQ FAQHAAQIRN ESSSEEEEEE GDLLQRRREE CERKARRGEM DPRLEFTFQL
LIDATQLPRH QLMDYIFEGD MLDEINQLFL PNMKNKLLWF FQEVDEPEPQ PVQDPNKPGP
SRSGMTPSTS KTPQGGTSPG GSAPAKQKKL FLTDGWTCAF TGICIYIFRI NTNKQLPEEG
FQKDLFCGII DAKNVGLVTS IERIIEYVFM QALAFPSLEG EEEDVSCGLI KGQLLPGLRS
FCSALRVCEQ VCDHFNVFDD GCDMFDHINH VEELKDLSKN QEFCGQLEER VTNWIKGITK
ILGESDQLRK ENDSSGPQDE LEYWKKRGAQ FSQLLAHLQT KEVQYTLHCL LLANSKVIRD
WKETDRKITF CYNEARDNSK FIQAMEHCCH SLYLDDPVCM KESILSLLQT VRLIYSVSQF
YNTSERTSAL MVKITNQMIE TCKSYITCRC KETIWTQDRT LVRTKLSNCI KLNHIYHETY
YTVREQPFLP NQTPFGFSEN FVFGKFDTFC ERLSKITSMF NLIDDYNHLF ERRLEGLLLA
EALEEASNHF EEAKKEILSK KYDYLDHRNA EFNDDYEKFI SKTDVLKDTI ATLIETNFDT
VWETPQCIRF LVRFEKVSEK IPLTKMDEKY MRIVRYVDKE VERVIKLFRK HRDDPPVQRN
FPPIAGRIYW SRSLHCHIRE LIDSVCDHPV LGALPPTRDV EIRFNHVANL LGEYEDEIIA
IWLDQDVSVA DACLLQPLLS LQGDRIFVNL HPTIPLLIRE AKLLAKIKVD LPIVAATLMS
RQDYFITIQD SLNNLLKMFL TTVRAVKLEV RPLFLPQLVR LTAMLKPGLT TINWTDQNWS
KFYERCKQAI ETFEVLVARI HDIYSNRILH VLMCMQEIKL QVLPGDDEIW TVDEFLEKSE
ESCRKAAIEL NRKSQMVSEA VEEVLNLVDK ASEKFKEMAG DDVVTLFDAS AKDQSSSSRK
GGENEGGGGG GNASSRGSGG AAGGGNAGNQ QQDWSILWSC FDNPLTLLAT TESLPKGMQD
MVCNAVVEMR RYYSRKVIDV LIKVIRAALD TIRRRFVSDD DDPVVKKPIF ALYAQLQIPN
VVIKPNLEEL QEILITAGKT ITGISKGVAQ WTSGKEQPQV SLTPQPRVGR NHNTKRRKLY
TLDSVQKPQM PHMLKSFYSA IMDNKEVAKA FNLLSNCTKG IKPEIQTYIK RWKPYHFLWK
NDRTTRQLME FGLQEFETTL RCLADLDANL LIEPDMEVFG NCLAVYNERL KYGLAIEIKS
CNHKIGQAMK KKYKKEMDYV YAVINEMDRK LDRPIRDLDD VRMIMETLGK IREQEVDMEL
RIDPIEEAFN VLTRYEVQVE REQFDLVDNL RATFQNLLAC ALQAQVKLLE MQPSFQDDLK
NNLDNFKQDK INYVLEYRTA GPMQPGLTPR EASDRLILFQ NRFEGMWRRL QTYQSGEELF
GLPQTDYPEL GQIRKELNLL QKLYKLYNDV IDRVSSYYDI PWNEVDIEEI NNELMEFQNR
CRKLPKALKE WPAFHALKKT IDDFNDMCPL LELMANKAMK PRHWQRIMDV TQYTFEFDSE
GFSLKNILEA PLLKYKEDIE DICISAMKEK DIEAKLKQVT NEWSVHELQF MSFNNRGELL
LRGDTTAETI GQLEDSLMVL GSLLSNRYNA PFRKQIQQWV YDLSNSNEIL ERWLLVQNMW
VYLEAVFVGG DIAKQLPKEA KRFSKIDKSW QKIMQRAHET PGVVACCVGD DLLKQLLPHL
QEQLEICQKS LSGYLERKRM MFPRFFFVSD PALLEILGQA SDSHTIQNHL LSIFDNTRHI
KFHDIEYNKM MAIISSEGEM IQLDRAIRAE GSVETWLTQL LVTAQASLHS IIRTAYATIN
DPNFSLLAFL DKAPAQIGLL GIQMIWTRDA EMALMQARQE RKVMSETNNK FLDILNILID
QTTRNLTKME RTNFETLITI HVHQRDIFDI LCRMNIKSAN DFEWLKQCRF YFKEDLDKTW
ISVTDVTFTY QNEYLGCTDR LVITPLTDRC YITLAQALTL SMGGAPCGPA GTGKTETVKD
MGKTLAKYVV VFNCSDQMDY RGLGRIYKGL AQSGSWGCFD EFNRIELPVL SVAAQQVAVV
LTAKKEKKKT FIFTDGDTIE MNPEFGIFIT MNPGYAGRKE LPENLKIQFR TVAMMVPDRQ
IIIRVKLASC GFLENITLAR KFYTLYKLCE EQLTKQVHYD FGLRNILSVL RTLGAAKRRN
SKDSESTIVM RVLRDMNLSK LIDDDEPLFI SLVSDLFPNQ TLEKTNYPEL EAAIAQQTEE
ANLVYHPPWV LKLIQLYETQ NVRHGIMTLG PSGAGKTTCI HTLMKALTQM GDVHREMRMN
PKAITAAQMF GRLDVATNDW TDGIFSALWR KTLKLKSGEY VWLVLDGPVD SIWIENLNSV
LDDNKTLTLA NGDRLTMAPT VKIIFEPHNI DNASPATVSR NGMVYMSSSG LDSRPIVQAW
LKNRAPGEKT VFWDLFERTF VQLINWGTQN LKLLMPVLQC NVVRQMLLIL EGLVPVKKED
EQAVSLCSKD SQDEEAAEEP AVEEKEDTCT PEHLHRLYIF ALAWGLGAYL SASDRIKMNN
YVKQSFPDLD YAKGTASENT IFDFFVSPAG TWQSWKTLVT PYMYPEVSTP DYLSILVPIV
DNVRMDYLIG TIANQEKAVM LIGEQGTGKT VIMKNFMRKM NVETYMGRSF NFSSATSPYQ
FQRTIESYVE KRVGVTFGPP GGRKLIVFID DVNLPEINEW GDQVTNEIVR QSMDMKGFYS
LEKPGDFTTI VDVQYVAAMG LPGGGRNDIP SRLKRQFCVF NCNIPDNDSI DKIFRVIGEG
HYNTKRCFIP EVRNLVKKLI VVTRYLWQRT REKLLPTPAK FHYVFSLRDL SRIWQGMVGT
LPTVITSESV LMSLWKHECI RVFADRFTNI PDKEWFGSEL ACLVRSELGE NYVQMIVPNP
VFVDFMRDAP EPTGEEGEDA DMELPKVYEP VTSHEVLRER LVMFLAQFNE MVRGSGMDLV
FFPDAMLHLV KISRIIRHPR GNVMLVGVGG SGKQSLTKLA SFIAGYKTFQ IALTRSYNVA
NFLEDLKLLY RTCGVQGKGT TFLFTDMDIK EEGFLEYLNN ILSSGVISNL FSRDEQAEIV
QELTPIMKRE NQRKTATPES VMEFFLARTC ANLHVAFCFS PVGETFRSRV QRFPALVSGC
TIDWFQPWPK DALVSVSRHF LSDFEIECTP EVKEELVNAL GSIQDVVSET SQEYFQRFRR
ATHVTPKSYL NFIAGYKNIY QQKQKELGDG VEKMDTGLEK LKEASASVEI LKKDLVVMEE
ELVEASKKAE SVLVEVTERA MQAEIVKNQV LIVKDKAEAL VACIAEEKAL AEEKLEAAKP
ALEEAEMALN TIKPAHIATV RKLGRPPHLI MRIMDCVLIL FKRKLHPCIP DSGTPCPKPS
WQESLKMMAS ATFLLQLQNY PKDTINDEMI DLLQPYFRME DYNMDMARRV CGDVAGLLSW
TKAMGFFHSV NKEVLPLKAN LTLQEARLKL AMDDLAAAED QLREREEALQ AVKNLYDNAV
GEKQRLTDAA NACLRKMTAA TALINGLSDE KIRWTNQSKE FKIQLGKLVG DVLLATGFLS
YCGPYNQEFR ANLIRTWMSI LKQKTIPFTT GLNIISMLVD SSTVSEWNLQ GLPNDELSVQ
NALIATKSSS YPMLIDPQAQ GKIWIKSKEE QHELQITSLN HKYFRTHLED ALSLGRPLLI
EDVGIELDPV LDNVLEKNFI KSGSIEKVLV GDKECDVMPG FMLYITTKLP NPAFSPEVSA
KTSIIDFTVT MRGLEDQLLG RVILMEKSDL EAERVSLFET VMQNQRNMKE LEANLLYRLS
SSQGSLVDDE DLIEVLRVTK TTAEEVNEKL KIAEFTERKI MKAREEFRAV AARGSILYFL
IVEMSNVNVM YQNSLKQFLV IFNNSITKST KSNVTEERIN IILRYLTYEV YKFTNRSLYE
RHKQLFTLML AIKIDYHNGN ISHEEFMAFI KGGASLDLNA VQPKPFRWIL DITWLNLVEI
SKLDTFVNVL ELIELNEREW RIWYESEKPE NEEIPCGYQS SLDSFRKLLL IRSWCPDRTI
SQAKKYIEES LGPEYSEMQI LDLELTWSES EPRTPFVCLL SIGSDPTTQI SALAKQKEIP
LKAVSMGQGQ EFHARKMIMD SMAGGGWVLL QNVHLSLPFC TEIIDMLVET EHVDESFRLW
VTTEPHNEFP IGLLQMAIKF TNEPPQGIRA SLKRSYQSFT QDFLDYTSAP QWPPLLYTVA
FLHTIVQERR KFGPLGWNIP YEFNAADFAA SVQFVQNHLD EMDPKKGVSW QTLVYMIGEV
QYGGRVTDDF DKRLLTTFTA VWFCEALLNP SFEFYKGYKV PNTKSLQGFI DAISNLPAND
TPEVFGLHSN ADITYQINSA KGILDTILSV QPKEGGGGGG ETRESIVYQL ADDMLRKLPP
QYNDYEVREN LVRMGILLPM NIFLRQEIDR MQKVIKRVYS CLCDLKLAID GTIIMSPALK
DSLDAMYDAR IPESWMKISW ESTTLGFWYT ELLERNAQFR TWISTDRPKV FWMTGFFNPQ
GFLTAMRQEV TRAHKGWALD SVVLQNQITR YNKEDITEYP QEGVYVYGLF LE
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