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Database: UniProt
Entry: A0A1I8M7U1_MUSDO
LinkDB: A0A1I8M7U1_MUSDO
Original site: A0A1I8M7U1_MUSDO 
ID   A0A1I8M7U1_MUSDO        Unreviewed;      1573 AA.
AC   A0A1I8M7U1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   11-DEC-2019, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:MDOA002138-PB, ECO:0000313|VectorBase:MDOA002138-PF};
GN   Name=101895418 {ECO:0000313|VectorBase:MDOA002138-PB,
GN   ECO:0000313|VectorBase:MDOA002138-PF};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA002138-PB};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA002138-PB, ECO:0000313|VectorBase:MDOA002138-PF}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA002138-PB};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G., Giers S.D.,
RA   Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M., Meisel R.P.,
RA   Minx P., Murphy T.D., Nelson D.R., Reid W.R., Rinkevich F.D.,
RA   Robertson H.M., Sackton T.B., Sattelle D.B., Thibaud-Nissen F.,
RA   Tomlinson C., van de Zande L., Walden K.K., Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of diseases
RT   with adaptations to a septic environment.";
RL   Genome Biol. 15:RESEARCH0466.1-RESEARCH0466.16(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA002138-PB, ECO:0000313|VectorBase:MDOA002138-PF}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA002138-PB,
RC   ECO:0000313|VectorBase:MDOA002138-PF};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   RefSeq; XP_011290831.1; XM_011292529.2.
DR   STRING; 7370.XP_005179389.1; -.
DR   GeneID; 101895418; -.
DR   KEGG; mde:101895418; -.
DR   VectorBase; MDOA002138-RB; MDOA002138-PB; MDOA002138.
DR   VectorBase; MDOA002138-RF; MDOA002138-PF; MDOA002138.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301}.
FT   DOMAIN          252..320
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          365..419
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          426..480
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          482..547
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          593..768
FT                   /note="PG1 pseudoGTPase"
FT                   /evidence="ECO:0000259|PROSITE:PS51852"
FT   DOMAIN          767..927
FT                   /note="PG2 pseudoGTPase"
FT                   /evidence="ECO:0000259|PROSITE:PS51853"
FT   DOMAIN          1362..1564
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          1329..1358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1329..1355
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1573 AA;  181701 MW;  BAE6D57F712A4407 CRC64;
     MKTFNISVIG LSGTEKDRGQ VGVGKSCLCN RFIRPMADDY FIDHISVLSQ SDFSGRVVNN
     DHFLYWGDVL KATDEGSEYS FHIIEQTEFM DDSTFQPFKV GKMETYLKRC TSTKVFSAEK
     LMYICKNQLG IEKEYEQKIM PDGRLAIDGF IVTFDVSPVP NRNIEKQVEF VQNAITLILK
     NKKPLVLVTT KNDDSCDLYV REAEKICQRK EYKGMIQMVE TSAHESINTD LPFLLLAQMI
     DKVKNRIKII PYQEAARSRK ELLESRSEAV TRLIRNQITD YHVLWTHGSK MLAQFREWTE
     FLNIFGHDAG QKLFRRHMKK LRDDYMNQRL HQYLDKFART LEYMLPDINA LSTSDDDIWE
     CAKSYMRNHV EFDQYFFECP QASWQELVDM DETEDEARIP FDVLETSEAE TVFRNFLNSV
     QQDKKKIGWK QQFKMLLEES GFVTPGKQLS EVRVLFMGRE CFEALSEHDC QQIYDIHQDE
     IIEKSKQNFI ELLLEHAQFF QQFKNVDIIT QEDVRQITDM LQDDSRYKIM DRLDQERRVI
     LFQHLGFMHC PIRDHCPFYH SCVDNFIEEI LTDKSAGSHK TLGSGGSGSW KSQGSDKTLN
     LLIVGSEHLA SDLLNDIRMC TGSKGEYIYE NQTYYLNYRI ANGDMEAFKA IDVYSSGLIC
     VYSNLQSFET LKDNLERTLL CNLELEDKFE NLPIVLVYQP HDLKENEVEY LRNEGLRLAE
     MLHCDFIDHQ QSHQKYVYEI LNIVIDSLRV AEMKTLETFP PNQTDLRILV CMFCGDQYDI
     ENIINPLTDE STFCKALEHS VVVDVFIGDS KKRVEFILSS YHGINQYRDE LIHGFIFVYS
     TKRRSSLANL SVLVSQNANI PLQIIAITES GGANAFFSSE LCQFLITEGN SLADRYKASF
     MTFSSDQYVK FAFYSPFLKN AWDNKYDVEN LHVEESITLD SGEGTLENSV KLPRPPPRHE
     SYMLSSTLGT DGSGSENYEM LPTRSLNSLN EERDISLDEI YEESNEKPKM IHQRFQIFPP
     PTTPPEPAPP DHQLITCSYK SQFVSASESS LEEITSDVSG SKDSLATHDA EWLDDKTDAR
     RNANKNSIWN NFGGSTHAYT TGRRHIDSNL NKIRPKGPSQ TLKQPGKLNM KNFQLVSDAV
     AKMNFGGDSY LPICESGDKD SKRYTQFDHS QLDGDEEDSE ELAEYEQIYE NEDCTESDSC
     ASSIERKNRQ QNAYYKQMNK KPPVNKKTKK KKVAIPVQTP RVPTMFGSYV SPPEIPLHYQ
     RMVTAEKKKI SDPSLINDMI KTDKSPEYTM VPDNPGLFGA PENLNEYNMN AKCLKEFEKS
     EKRRLKEENT RLRKLQEKEK EQEKKLKRKL KQNSKGFPDT ESQFEKLMIS DKVEIPIFLI
     KCIEYIEKEG LDSEGIYRVP GSRAHVDLLF QKFEEDSNTV IELLDIPVNA VATALKDFFS
     KRLPPLFSKD IIKELEEVAG SRTVCGSKVN VEVKTDRSCR LMALKTLLEK LPPVNFAILK
     YIFQHFVHVS DNSKLNSMDS KNLAICWWPT LIPIDFTDMG HFEQLRPYLE DIVQTMIDQY
     PYLFCGEDAF VMV
//
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