ID A0A1I8M949_MUSDO Unreviewed; 283 AA.
AC A0A1I8M949;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=omega-amidase {ECO:0000256|ARBA:ARBA00039118};
DE EC=3.5.1.3 {ECO:0000256|ARBA:ARBA00039118};
DE AltName: Full=Nitrilase homolog 2 {ECO:0000256|ARBA:ARBA00041576};
GN Name=101892560 {ECO:0000313|EnsemblMetazoa:MDOA002509-PA};
GN Synonyms=LOC101892560 {ECO:0000313|RefSeq:XP_005182949.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA002509-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA002509-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA002509-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005182949.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005182949.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+);
CC Xref=Rhea:RHEA:32963, ChEBI:CHEBI:15377, ChEBI:CHEBI:16769,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:28938; EC=3.5.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00036637};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32964;
CC Evidence={ECO:0000256|ARBA:ARBA00036637};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxosuccinamate + H2O = NH4(+) + oxaloacetate;
CC Xref=Rhea:RHEA:59412, ChEBI:CHEBI:15377, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:57735; EC=3.5.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00036705};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59413;
CC Evidence={ECO:0000256|ARBA:ARBA00036705};
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DR RefSeq; XP_005182949.1; XM_005182892.3.
DR STRING; 7370.A0A1I8M949; -.
DR EnsemblMetazoa; MDOA002509-RA; MDOA002509-PA; MDOA002509.
DR GeneID; 101892560; -.
DR KEGG; mde:101892560; -.
DR VEuPathDB; VectorBase:MDOA002509; -.
DR eggNOG; KOG0806; Eukaryota.
DR OrthoDB; 1365844at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR CDD; cd07572; nit; 1.
DR Gene3D; 3.60.110.10; Carbon-nitrogen hydrolase; 1.
DR InterPro; IPR003010; C-N_Hydrolase.
DR InterPro; IPR036526; C-N_Hydrolase_sf.
DR InterPro; IPR045254; Nit1/2_C-N_Hydrolase.
DR PANTHER; PTHR23088; NITRILASE-RELATED; 1.
DR PANTHER; PTHR23088:SF30; OMEGA-AMIDASE NIT2; 1.
DR Pfam; PF00795; CN_hydrolase; 1.
DR SUPFAM; SSF56317; Carbon-nitrogen hydrolase; 1.
DR PROSITE; PS50263; CN_HYDROLASE; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 9..256
FT /note="CN hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS50263"
SQ SEQUENCE 283 AA; 32122 MW; 03C316AB6380504B CRC64;
MSKVVNNLMR LALLQLNVSK DKLVNLQHAS QKIREAVKEH KPRIVTLPEC FNSPYGTKYF
REYAESIPSG ETSQTLSQLA KEMGIYIVGG SIPELASDDK IYNTCTIWSP EGNLIAKHRK
MHLFDIDVKG GIRFKESETL SAGNEFTIIE VDGHKIGIGI CYDIRFEEMA KVYRNEGCEM
LIYPAAFNMT TGPMHWELLQ RSRANDNQLY VVTTSPARDE KGEYVAYGHS MVVDPWAKVV
KSAKEGEETV VADIDFSLVE QVRQQIPVYS QRRLDLYSTN KKC
//
