ID   A0A1I8M9R4_MUSDO        Unreviewed;      1461 AA.
AC   A0A1I8M9R4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   Name=101897554 {ECO:0000313|EnsemblMetazoa:MDOA002675-PB};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA002675-PB};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA002675-PB}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA002675-PB};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. STE20 subfamily.
CC       {ECO:0000256|ARBA:ARBA00008874}.
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DR   EnsemblMetazoa; MDOA002675-RB; MDOA002675-PB; MDOA002675.
DR   VEuPathDB; VectorBase:MDOA002675; -.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   CDD; cd06608; STKc_myosinIII_N_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR47096:SF1; CNH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47096; MISSHAPEN LIKE KINASE 1; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00036; CNH; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022777}.
SQ   SEQUENCE   1461 AA;  160754 MW;  65520A7ECB5C26C8 CRC64;
     MAHQQLASVN CPLDDIDLAA LRDPAGIFEL IEVVGNGTYG QVYKGRHTKT GQLAAIKVMD
     VTEDEEEEIK LEINVLKKYS NHRNIATYYG AFIKKSPPGK DDQLWLVMEY CGAGSVTDLV
     KSTKGQSLKE EWIAYICREI LRGLAYLHSN KVIHRDIKGQ NVLLTDNAEV KLVDFGVSAQ
     LDRTIGRRNT FIGTPYWMAP EVIACDENPE ATYDNRSDLW SLGITALEMA ESQPPLCDLH
     PMRALFLIPR NSPPRLKSNR KWSKKFQSFI DTVLVKDYHQ RPYTEQLLKH AFIKDQPTDR
     QVRIQLKDHI DRCKKRKQEK EREDYRYSGS DNDDDDTQIA GEPSSIIQAP GDTLRRNFQQ
     IQEGRIAAEQ QQQQQQMAAV AAAQAAAAQA QAAQQQQQQQ AQAQQPQANR NQKPPSRDQR
     QQIEEPGPPS RPALPQRLIV VPDPPHANRP LPPTPKSSES SSAAQTPQQQ QRNSQNNFKP
     SLPPRRPEPQ PQTASAATSS FAQQSAQPEA PPRNNRQSGG PPSGSGKPAA PLPTSGNNHH
     HVAVSNPLDP LDSSDSDSEP DEPNDRGRND GTLLASDPPK PLPGLVPVSE DSSSTPITHG
     SGGPPNRPLP PTPDDDDQAG DRTLIMKRKF ENQNRLQKSA STSCANRPKN ELRDVALLRE
     WDIEKFFPKQ SASSGAGGGG GAVGSNDNLS AAVTTGVSSS LSRVPSSSNS STLKADSKLQ
     RCSMAEVPSS RQTPKGFQPI KTGAQQAQTK DQTRASMMSV SSRTKASSTN GSNNNSSNNN
     NNNNKSSPTS STSSSASPAN TNALRSANNN ATHKRQESDS KLPQNFIRGF RRENSDFFPL
     TKRHSAVLVN TNLLQQQQQQ SSPFGSAAQR ASAMIPRNNS IFNNNKNDLN KSAKETNSAA
     NKSTQNANAK SSGSTSGSTT ANAPNKTSWT SNLDFLRPRR EKTESVIVFQ NSAARQQLFA
     QQLVQQQQKQ HQQQNRNTEN LGTPGTRTSS VLPDLLSQAS PATPPRHDKS SSEEYQAAIN
     SSVHSTPSKS FIGGSNNSPQ STISLHSSSS RQNSPKNSIS KTRSSSSITN LLHKSASSSN
     ASAAALPVPP YALQQKQRSF LTFGFGAGGS GPSRRESHVN VNVTPTSHEA SSDTPEIRKY
     KKRFNSEILC AALWGVNLLI GTENGLMLLD RSGQGKVYQL ISRRRFQQME VLEGQNILVT
     ISGKKNRVRV YYLSWLKSKI LRTDGLSDQV ERRNGWINVG DLQGAVHFKI VKYERIKFLV
     IALKDSIEIY AWAPKPYHKF MAFKNFGELE HRPLLVDLTI EDQSRLKVIY GSAEGFHAVD
     LDSAEVYDIY LPKHTQGAII PHCIVALPNS NGMQLLLCYD NEGVYVNTVG RVSKNIVLQW
     GEMPTSVAYI GTGQIMGWGN KAIEIRSVET GHLDGVFMHK KAQRLKFLCE RNDKVFFSSA
     KGASSCQIYF MTLNKPGMAN W
//