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Database: UniProt
Entry: A0A1I8MA25_MUSDO
LinkDB: A0A1I8MA25_MUSDO
Original site: A0A1I8MA25_MUSDO 
ID   A0A1I8MA25_MUSDO        Unreviewed;       474 AA.
AC   A0A1I8MA25;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   18-SEP-2019, entry version 21.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:MDOA002759-PI};
GN   Name=101901470 {ECO:0000313|VectorBase:MDOA002759-PI};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA002759-PI};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA002759-PI}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA002759-PI};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA002759-PI}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA002759-PI};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_005183505.1; XM_005183448.3.
DR   GeneID; 101901470; -.
DR   VectorBase; MDOA002759-RI; MDOA002759-PI; MDOA002759.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    145    168       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    227    251       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    256       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      263    434       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION       11     33       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS     11     28       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   474 AA;  54304 MW;  1ABDB88A0FD3223D CRC64;
     MISRLRCNLM NSYSTSDDGN QTSPESDKSV MEPLADPKKF TKSVSIDPEP DSLDSVLSNP
     HSYPITIIPN RPTTYYGLTM HNGKPFTRQA SCRSRNFRPG SMRKVRRRAV FKNGDCNVLQ
     KNLTRRRLRF LQDMYTTLVD TQWRWTLLAF ALSFILSWLI FAVLWWLIMY THGDLEELHL
     PHNQEESGWQ PCVSAINGFT SCFLFSIETQ HTIGYGVRTT SEECPEAIFM MCFQSIYGVM
     SSAFMAGIVF AKMTRAKQRA QTLLFSKNAV ICQRDGSLSL MFRVGDMRKS HIIGAGVRAQ
     LIRTKTTKEG EVMTQHFTDL EIGADDCGSD IFFIWPMVIE HKIDENSPLY NMSATDILND
     KFEIVVILEG TVESTGQSTQ ARSSYINTEI LWGHRFDPVV VYNKDRQAYE IDYARFNETT
     QVDTPLCSAR DLNEIYKIQE GFTTPGRHKS PPISPLYSAK QQNVVYRWQF SNEI
//
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