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Database: UniProt
Entry: A0A1I8MD94_MUSDO
LinkDB: A0A1I8MD94_MUSDO
Original site: A0A1I8MD94_MUSDO 
ID   A0A1I8MD94_MUSDO        Unreviewed;      5119 AA.
AC   A0A1I8MD94;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   25-APR-2018, entry version 14.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:MDOA003721-PB};
GN   Name=101888405 {ECO:0000313|VectorBase:MDOA003721-PB};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003721-PB};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003721-PB}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA003721-PB};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA003721-PB}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA003721-PB};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   RefSeq; XP_019890193.1; XM_020034634.1.
DR   GeneID; 101888405; -.
DR   VectorBase; MDOA003721-RB; MDOA003721-PB; MDOA003721.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4450   4470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4645   4663       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4725   4747       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4914   4936       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4990   5013       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    148       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      155    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      577    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1032   1217       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1448   1669       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      460    480       {ECO:0000256|SAM:Coils}.
FT   COILED     3795   3815       {ECO:0000256|SAM:Coils}.
FT   COILED     4582   4602       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5119 AA;  580137 MW;  D5A2A31D31814D25 CRC64;
     MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNVPPDLS
     QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHNNS DMYLACLSTS
     SSNDKLSFDV GLQEHSQGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE
     NEQSIVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWGREAG
     QNIVVYEGGS VMSQARSLWR LELARTKWTG GFINWFHPMR IRHITTGRYL GVNDNNELIL
     VKKEEASIAT TTFCLRQEKD DEKKVLEDKD LEVIGSPIIK YGDTTVIVQH CETSLWLSYK
     SYETKKKGVG KVEEKQAILH EEGKMDDCLD FSRSQEEESK TARVIRKCSS LFTQFINALE
     TLQNNRRHSI FFQKVNLNEM VMCLEDLINY FSQPPDDMEH EEKQNRFRAL RNRQDLFQEE
     GVLNLILEAI DKINIITSQG FLASFLAGDE MGQSWDLIST YLYQLLAAII QGNHTNCAQF
     ANSNRLNWLF SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
     PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTQ LVDHVASIRP NIFVGRVENS
     AMYQKWYFEV TMDHIEQTTH MMPHLRIGWA NTAGYVPYPG GGKKWGGNGV GDDLYSFGFD
     GAYLWTGGRK TLVTDVIPEE PYIRKGDVIG VTIDLSIPII TFTFNGLKVK GCFRDFNLDG
     MFFPVMSCSS KLSCRFLFGG DHGRLKFAPP PGFSPLVQCL MPHQILSLDP CFYFGNLTKN
     VLAGPWMIED DTAFVPNPVD TSGVTLPSSV DQIKEKLAEN IHEMWALNKI EAGWSWGEHR
     DDYHRIHPCL TQFEKLPPAE KRYDNQLAVQ TLKTIIALGY YITMDKPPAR IRPIRLPNEI
     FMQANGYKPA PLDLSAVTLT PKLEELVDQL AENTHNLWAR ERIQQGWTYG LNEDSENLRS
     PHLVPYSKVD EAIKKANRDT ASETVRTLLV YGYVLDPPTG EGNEALLAEA LRLKFAAFRT
     YRVERNYAVT SGKWYFEFEV LTSGPMRVGW ARADCNPGAM LGSEDTSWAF DGHNVTKIHA
     GSVEHFGVRY EAGDVIGCFI DVKEQTISFS LNGELLMDAL GGETTFADVT AEGVGFVPAC
     TLGVGQKARL IYGQDVDSLR FFTTCGLQEG YEPFCVNMRR PVTHWYTKDQ PIFENTEEMP
     DCRIDVTRIP GGSDTPPHLK ISHNTFETME KANWEFLRLS LPVTCMGEFI SEAEKARRWE
     EIKMRQYRLM REAQEIAQQQ TSAHMDHMLK SGFSMNDIKG LNRNYDDTAE ADENMARSPA
     RPPRRASMTR NITFESDLGV SEELQRSTSA LDMNGIEDGG AMDDKKKRGR SPFKFFSKKT
     RDQSKDKLPG RAPEVSPERR TAMTQGRSAA ASQLTAKAPS LRLNNTEMPQ TPTQGPKALS
     GGNLGQPAVE SSGDEMFDAE CLKLINEYFY GVRIFPGQDP THVYVGWVTT QYHLHSKEFN
     KDKVRRGSVI IEDDYEMPIE RINRQSCYVV RADELFNEVT QDASGKGASQ GMFVGCFVDT
     ATGMISFTCE GKPTSHRWQM EPNTKLFPAI FVEATSKEIL QIELGRTATT LPLSAAVLPT
     SDKHINPQSP PRLKVQCLRP HQWARVPNTA LQVHALKLSD IRGWSMLCED PVSMLALHIP
     EEDRCIDILE LIEMDKLLSF HAHTLTLYAA LCYQSNYRAA HALCQHVDQK QLLYAIRSEY
     MSGPLRQGFY DLLIALHLES HATTMEACKM EYIIPLGPEL KFLYDDEEMR HSLRSLVTES
     VRPQMRMTEI TPISIQTNAS SEPIPDIDHL YSPKFPLEVV REFVMEALKE AVEINQVHNR
     DPIGWTNENL FLPLLKLTDR LFLVGVMTDE DVQKLLVMID PETWDPSFEK DGKDEHRKGL
     LTMKMAEGAK LQMCYLLHHL YDIQLRHRVE SIIAFSHDFV GDLQADQLRR YIEIKQSDLP
     SAVAAKKTKE FRCPPREQMN QILCFKNLEP DDHENCTCGL ELRGSLYDFH DSLMKKVSLN
     ALQEPDEAES TAVEEVKTGP ITKIYNFINT VKELEEGPKE VEEPEKKTPE EVFRKVLIKT
     IVSWAEESQI ETPKLVREMF SLLVRQYDTV GELVRALEKT YVINNKARDD VAEMWVGLSQ
     IRALLPVQMS QEEEELMRKR LWKLVNNATF FQHPDLIRIL RIHENVMAVM MNTLGRRAQA
     QSDAPAQQEG MEGAPPKEKD TSHEMVVACC RFLCYFCRTG RQNQKAMFDH FDFLLDNANI
     LLARPSLRGS TPLDVAYSSL MENTELALAL REHYLEKIAV YLSRCGLQSN SELVEKGYPD
     LGWDPVEGER YLDFLRYCVW VNGESVEENA NLVIRLLIRR PECLGPALRG EGEGLFRAIV
     EANRMSERIS DRYKMQDEAE GTIAGLNFSH PLPEGDEDED YIDTGAAILN FYCTLVDLLG
     RCAPDASVIE QGKNESLRAR AILRSLVPLE DLQGVLSLKF TLTQTAPGEE KPKSDMPSGL
     LPNNKQSIVL FLERVYGIET QELFYRLLED AFLPDLRTAT ILDKSDGSES DMALSMNRYI
     GNSILPLLIK HSKFYNEAEN YASLLDATLH TVYRLSKNRM LTKGQREAVS DFLVALTSQM
     QPAMLLKLLR KLTVDVSKLS EYTTVALRLL TLHFDRCAKY YGSSQGQGSY GAASDEEKRL
     TMLLFSNIFD SLSNMDYDPE LFGKALPCLI AIGCALPPDY SLSKNSDEDY YGRQSGAPDQ
     PQYDPNPIET SNVNLTHDYN SLVEKFSEHY HDAWASRRLE SGWTYGEVRS DTDRKHPRLK
     PCNMLTEYER ERYRDPVREC LKALLALGWT IEHSEIEVPQ NNRGSTRRQS KPQINDFQNE
     GSSFNYNPHP VDMTNLTLSR EMQNMAERLA ENSHDIWAKK KKEELNSCGG VIHPQLVPYD
     LLTDKEKRKD RERSQEFLKY MQYQGYKLHK PSKGGALEGE GGATQASAEL RFSYSLLEKL
     IQYLDRATIN MKLLKPSTTF SRRTSFKTAS RDIKFFSKVV LPLMEKYFST HRNYFIAVAT
     ATNNVGAASL KEKEMVAAIF CKLASLLRNR LTAFGPDVRI TVRCLQVLVK GIDARTLVKN
     CPEFIRTSML TFFNQTADDL GNTILNLQDG KYSHLRGTHL KTSTSLGYIN QVVMPVLTAM
     FDHLAACDYG SDLLLDEIQV ASYKILAALY HLGTDGSLTQ DRKYLKTEIE RHRPALGSCL
     GAFSSCFPVA FFEPHLNKHN QFSLLNRIAD HSLEAQDIMV KMESCMPNLE TVLAEVDQFV
     ESDKTYHDAP HVIDVILPLL CSYLPFWWSQ GPDNVSPTSG NHVTMVTADH MNSLLRNVLK
     MIKKNIGNDN APWMTRIAAY TQQIIINTSE ELLKDPFLPL AERVKKRTEN MFHKEESMRG
     FIKSATDDTS QVETQLQEDW NLLVRDIYSF YPLLIKYVDL QRNHWLKDNI PEAEELYNHV
     AEIFNIWSKS QYFLKEEQNF ISANEIDNMA LIMPTATRRS AITEGAPVTG GKVKKKKKNR
     DKKRDKDKEI QASLMVACLK RLLPVGLNLF AGREQELVQH CKDRYLKKMP EYDVIEFARN
     QLTLPDKLDP SDEMSWQHYL YSKLGKKEEP TEEQTAIEKA ANQNDKGRDK TQETVDRIVA
     MAKVLYGLHM IDHPQQQSKN VYRSVVSIQR KRAVIACFRQ TSLHSLPRHR ACNIFARTYY
     EQWLQEENVG QEVMIEDLTQ TFEDFEKSKK DEDETEAKPD PLTQLVTTFC RGAMTERSGA
     LQEDPLYMSY AQIAAKSCGE EEEEGGDEEG GEEEGEGTSI HEQEMEKQKL LFHQARLSNR
     GVAEMVLLHI SASKGIPSEM VMTTLNLGIS ILRGGNIDIQ MGMLNHLKEK KDVGFFTSIA
     GLMNSCSVLD LDAFERNTKA EGLGVGSEGA AGEKNMHDAE FTCALFRFIQ LTCEGHNLEW
     QNYLRTQAGN TTTVNVVICT VDYLLRLQES IMDFYWHYSS KEIIDPAGKA NFFKAIGVAS
     QVFNTLTEVI QGPCTLNQQA LAHSRLWDAV GGFLFLFSHM QEKLSKHSSQ VDLLKELLNL
     QKDMITMMLS MLEGNVVNGT IGKQMVDTLV ESAGNVELIL KYFDMFLKLK DLIESPSFME
     IDIKNEGWVT PKDFRDKMEQ SKNYTPEEID FLLACCERNH EGKIDYAGFV DRFHEPSKEI
     GFNLAVLLTN LSEHMPNEPR LARFLETAGS VLNYFEPFLG RIEILGSSKR IERVYFEIKD
     SNIEQWEKPQ IRESKRAFFY SIVTEGGDKE KLEAFVNFCE DAIFEMTHAS GLMATDDGGG
     NVKRDTSYSS YMSEEEEERA ARDPIRRTIN AVKEGLKFGV HMLSPSNIKH QIGVMQTKTV
     PELIIGFFKI IFYMFYYTGY AHFAVVRYIF GILMNLMRGP APEEVEEAPV EEETFGRALP
     PLPIEEPPGT VQAFGLDINK EENGQYKVTV HESSGGSPSS SMEETGESSP EDGGPAGEVP
     VEGEAHHPEP VSIVDLLGGE AAKKAAQERQ EAQKAQEAAM ASIEAEAKKS SSAPQETPAV
     NQIDFSQYTH RAVSFLARNF YNLKYVALVL AFSINFMLLF YKVTSLTDDE ESSGDDVLIL
     GSGSGAGLAG SGMGSGDGSG DGEGEEDEIP EMVHVDEDFF YMEHVIRIAA LMHSLVSLAM
     LIAYYHLKVP LAIFKREKEI ARRLEFDGLF IAEQPEDDDF KSHWDKLVIS AKSFPVNYWD
     KFVKKKVRQK YSETFDFDNI SNLLGMEKSS FMAQESEEGG LIKYITNIDW RYQVWKAGVT
     FTDNAFLYSL WYFSFSVMGN FNNFFFAAHL LDVAVGFKTL RTILQSVTHN GKQLVLTVML
     LTIIVYIYTV IAFNFFRKFY IQEEDEEVDK KCHDMLTCFV FHLYKGVRAG GGIGDEIGDP
     VGDEYEVYRI IFDITFFFFV IVILLAIIQG LIIDAFGELR DQLESVKENM ESNCFICGMG
     KDFFDIVPHG FDTHVQKEHN LANYMFFLMH LINKPDTEYT GQETYVWNMY QQRSWDFFPV
     GDCFRKQYED ELSGGGGGG
//
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