ID A0A1I8MD99_MUSDO Unreviewed; 5109 AA.
AC A0A1I8MD99;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Ryanodine receptor isoform X10 {ECO:0000313|RefSeq:XP_019890196.1};
GN Name=101888405 {ECO:0000313|EnsemblMetazoa:MDOA003721-PD};
GN Synonyms=LOC101888405 {ECO:0000313|RefSeq:XP_019890196.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA003721-PD};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA003721-PD}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA003721-PD};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_019890196.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_019890196.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR RefSeq; XP_019890196.1; XM_020034637.1.
DR EnsemblMetazoa; MDOA003721-RD; MDOA003721-PD; MDOA003721.
DR VEuPathDB; VectorBase:MDOA003721; -.
DR OrthoDB; 3144451at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF8; RYANODINE RECEPTOR 44F-LIKE PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50919; MIR; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_019890196.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4440..4460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4635..4653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4715..4737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4904..4926
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4980..5003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..148
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 577..803
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1032..1217
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1448..1669
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1369..1512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2268..2289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2797..2819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2909..2939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3573..3597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3680..3701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3847..3874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4520..4554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4677..4696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1418..1454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1461..1500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3851..3865
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4520..4537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5109 AA; 578971 MW; 734A6517F0741CD5 CRC64;
MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNVPPDLS
QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHNNS DMYLACLSTS
SSNDKLSFDV GLQEHSQGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE
NEQSIVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWGREAG
QNIVVYEGGS VMSQARSLWR LELARTKWTG GFINWFHPMR IRHITTGRYL GVNDNNELIL
VKKEEASIAT TTFCLRQEKD DEKKVLEDKD LEVIGSPIIK YGDTTVIVQH CETSLWLSYK
SYETKKKGVG KVEEKQAILH EEGKMDDCLD FSRSQEEESK TARVIRKCSS LFTQFINALE
TLQNNRRHSI FFQKVNLNEM VMCLEDLINY FSQPPDDMEH EEKQNRFRAL RNRQDLFQEE
GVLNLILEAI DKINIITSQG FLASFLAGDE MGQSWDLIST YLYQLLAAII QGNHTNCAQF
ANSNRLNWLF SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTQ LVDHVASIRP NIFVGRVENS
AMYQKWYFEV TMDHIEQTTH MMPHLRIGWA NTAGYVPYPG GGKKWGGNGV GDDLYSFGFD
GAYLWTGGRK TLVTDVIPEE PYIRKGDVIG VTIDLSIPII TFTFNGLKVK GCFRDFNLDG
MFFPVMSCSS KLSCRFLFGG DHGRLKFAPP PGFSPLVQCL MPHQILSLDP CFYFGNLTKN
VLAGPWMIED DTAFVPNPVD TSGVTLPSSV DQIKEKLAEN IHEMWALNKI EAGWSWGEHR
DDYHRIHPCL TQFEKLPPAE KRYDNQLAVQ TLKTIIALGY YITMDKPPAR IRPIRLPNEI
FMQANGYKPA PLDLSAVTLT PKLEELVDQL AENTHNLWAR ERIQQGWTYG LNEDSENLRS
PHLVPYSKVD EAIKKANRDT ASETVRTLLV YGYVLDPPTG EGNEALLAEA LRLKFAAFRT
YRVERNYAVT SGKWYFEFEV LTSGPMRVGW ARADCNPGAM LGSEDTSWAF DGHNEEKVFG
GVSESFGKQC GPGDIVGVFL DLADHTISFS LNGELLMDAL GGETTFADVT AEGVGFVPAC
TLGVGQKARL IYGQDVDSLR FFTTCGLQEG YEPFCVNMRR PVTHWYTKDQ PIFENTEEMP
DCRIDVTRIP GGSDTPPHLK ISHNTFETME KANWEFLRLS LPVTCMGEFI SEAEKARRWE
EIKMRQYRLM REAQEIAQQQ TSAHMDHMLK SGFSMNDIKG LNRNYDDTAE ADENMARSPA
RPPRRASMTR NITFESDLGV SEELQRSTSA LDMNGIEDGG AMDDKKKRGR SPFKFFSKKT
RDQSKDKLPG RAPEVSPERR TAMTQGRSAA ASQLTAKAPS LRLNNTEMPQ TPTQGPKALS
GGNLGQPAVE SSGDEMFDAE CLKLINEYFY GVRIFPGQDP THVYVGWVTT QYHLHSKEFN
KDKVRRGSVI IEDDYEMPIE RINRQSCYVV RADELFNEVT QDASGKGASQ GMFVGCFVDT
ATGMISFTCE GKPTSHRWQM EPNTKLFPAI FVEATSKEIL QIELGRTATT LPLSAAVLPT
SDKHINPQSP PRLKVQCLRP HQWARVPNTA LQVHALKLSD IRGWSMLCED PVSMLALHIP
EEDRCIDILE LIEMDKLLSF HAHTLTLYAA LCYQSNYRAA HALCQHVDQK QLLYAIRSEY
MSGPLRQGFY DLLIALHLES HATTMEACKM EYIIPLGPEL KFLYDDEEMR HSLRSLVTES
VRPQMRMTEI TEPIPDIDHL YSPKFPLEVV REFVMEALKE AVEINQVHNR DPIGWTNENL
FLPLLKLTDR LFLVGVMTDE DVQKLLVMID PETWDPSFEK DGKDEHRKGL LTMKMAEGAK
LQMCYLLHHL YDIQLRHRVE SIIAFSHDFV GDLQADQLRR YIEIKQSDLP SAVAAKKTKE
FRCPPREQMN QILCFKNLEP DDHENCTCGL ELRGSLYDFH DSLMKKVSLN ALQEPDEAES
TAVEEVKTGP ITKIYNFINT VKELEEGPKE VEEPEKKTPE EVFRKVLIKT IVSWAEESQI
ETPKLVREMF SLLVRQYDTV GELVRALEKT YVINNKARDD VAEMWVGLSQ IRALLPVQMS
QEEEELMRKR LWKLVNNATF FQHPDLIRIL RIHENVMAVM MNTLGRRAQA QSDAPAQQEG
MEGAPPKEKD TSHEMVVACC RFLCYFCRTG RQNQKAMFDH FDFLLDNANI LLARPSLRGS
TPLDVAYSSL MENTELALAL REHYLEKIAV YLSRCGLQSN SELVEKGYPD LGWDPVEGER
YLDFLRYCVW VNGESVEENA NLVIRLLIRR PECLGPALRG EGEGLFRAIV EANRMSERIS
DRYKMQDEAE GTIAGLNFSH PLPEGDEDED YIDTGAAILN FYCTLVDLLG RCAPDASVIE
QGKNESLRAR AILRSLVPLE DLQGVLSLKF TLTQTAPGEE KPKSDMPSGL LPNNKQSIVL
FLERVYGIET QELFYRLLED AFLPDLRTAT ILDKSDGSES DMALSMNRYI GNSILPLLIK
HSKFYNEAEN YASLLDATLH TVYRLSKNRM LTKGQREAVS DFLVALTSQM QPAMLLKLLR
KLTVDVSKLS EYTTVALRLL TLHFDRCAKY YGSSQGQGSY GAASDEEKRL TMLLFSNIFD
SLSNMDYDPE LFGKALPCLI AIGCALPPDY SLSKNSDEDY YGRQSGAPDQ PQYDPNPIET
SNVNLTHDYN SLVEKFSEHY HDAWASRRLE SGWTYGEVRS DTDRKHPRLK PCNMLTEYER
ERYRDPVREC LKALLALGWT IEHSEIEVPQ NNRGSTRRQS KPQINDFQNE GSSFNYNPHP
VDMTNLTLSR EMQNMAERLA ENSHDIWAKK KKEELNSCGG VIHPQLVPYD LLTDKEKRKD
RERSQEFLKY MQYQGYKLHK PSKGGALEGE GGATQASAEL RFSYSLLEKL IQYLDRATIN
MKLLKPSTTF SRRTSFKTAS RDIKFFSKVV LPLMEKYFST HRNYFIAVAT ATNNVGAASL
KEKEMVAAIF CKLASLLRNR LTAFGPDVRI TVRCLQVLVK GIDARTLVKN CPEFIRTSML
TFFNQTADDL GNTILNLQDG KYSHLRGTHL KTSTSLGYIN QVVMPVLTAM FDHLAACDYG
SDLLLDEIQV ASYKILAALY HLGTDGSLTQ DRKYLKTEIE RHRPALGSCL GAFSSCFPVA
FFEPHLNKHN QFSLLNRIAD HSLEAQDIMV KMESCMPNLE TVLAEVDQFV ESDKTYHDAP
HVIDVILPLL CSYLPFWWSQ GPDNVSPTSG NHVTMVTADH MNSLLRNVLK MIKKNIGNDN
APWMTRIAAY TQQIIINTSE ELLKDPFLPL AERVKKRTEN MFHKEESMRG FIKSATDDTS
QVETQLQEDW NLLVRDIYSF YPLLIKYVDL QRNHWLKDNI PEAEELYNHV AEIFNIWSKS
QYFLKEEQNF ISANEIDNMA LIMPTATRRS AITEGAPVTG GKVKKKKKNR DKKRDKDKEI
QASLMVACLK RLLPVGLNLF AGREQELVQH CKDRYLKKMP EYDVIEFARN QLTLPDKLDP
SDEMSWQHYL YSKLGKKEEP TEEQTAIEKA ANQNDKGRDK TQETVDRIVA MAKVLYGLHM
IDHPQQQSKN VYRSVVSIQR KRAVIACFRQ TSLHSLPRHR ACNIFARTYY EQWLQEENVG
QEVMIEDLTQ TFEDFEKSKK DEDETEAKPD PLTQLVTTFC RGAMTERSGA LQEDPLYMSY
AQIAAKSCGE EEEEGGDEEG GEEEGEGTSI HEQEMEKQKL LFHQARLSNR GVAEMVLLHI
SASKGIPSEM VMTTLNLGIS ILRGGNIDIQ MGMLNHLKEK KDVGFFTSIA GLMNSCSVLD
LDAFERNTKA EGLGVGSEGA AGEKNMHDAE FTCALFRFIQ LTCEGHNLEW QNYLRTQAGN
TTTVNVVICT VDYLLRLQES IMDFYWHYSS KEIIDPAGKA NFFKAIGVAS QVFNTLTEVI
QGPCTLNQQA LAHSRLWDAV GGFLFLFSHM QEKLSKHSSQ VDLLKELLNL QKDMITMMLS
MLEGNVVNGT IGKQMVDTLV ESAGNVELIL KYFDMFLKLK DLIESPSFME IDIKNEGWVT
PKDFRDKMEQ SKNYTPEEID FLLACCERNH EGKIDYAGFV DRFHEPSKEI GFNLAVLLTN
LSEHMPNEPR LARFLETAGS VLNYFEPFLG RIEILGSSKR IERVYFEIKD SNIEQWEKPQ
IRESKRAFFY SIVTEGGDKE KLEAFVNFCE DAIFEMTHAS GLMATDDGGG NVKRDTSYSS
YMSEEEEERA ARDPIRRTIN AVKEGLKFGV HMLSPSNIKH QIGVMQTKTV PELIIGFFKI
IFYMFYYTGY AHFAVVRYIF GILMNLMRGP APEEVEEAPV EEETFGRALP PLPIEEPPGT
VQAFGLDINK EENGQYKVTV HESSGGSPSS SMEETGESSP EDGGPAGEVP VEGEAHHPEP
VSIVDLLGGE AAKKAAQERQ EAQKAQEAAM ASIEAEAKKS SSAPQETPAV NQIDFSQYTH
RAVSFLARNF YNLKYVALVL AFSINFMLLF YKVTSLTDDE ESSGDDVLIL GSGSGAGLAG
SGMGSGDGSG DGEGEEDEIP EMVHVDEDFF YMEHVIRIAA LMHSLVSLAM LIAYYHLKVP
LAIFKREKEI ARRLEFDGLF IAEQPEDDDF KSHWDKLVIS AKSFPVNYWD KFVKKKVRQK
YSETFDFDNI SNLLGMEKSS FMAQESEEGG LIKYITNIDW RYQVWKAGVT FTDNAFLYSL
WYFSFSVMGN FNNFFFAAHL LDVAVGFKTL RTILQSVTHN GKQLVLTVML LTIIVYIYTV
IAFNFFRKFY IQEEDEEVDK KCHDMLTCFV FHLYKGVRAG GGIGDEIGDP VGDEYEVYRI
IFDITFFFFV IVILLAIIQG LIIDAFGELR DQLESVKENM ESNCFICGMG KDFFDIVPHG
FDTHVQKEHN LANYMFFLMH LINKPDTEYT GQETYVWNMY QQRSWDFFPV GDCFRKQYED
ELSGGGGGG
//
