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Database: UniProt
Entry: A0A1I8MDA0_MUSDO
LinkDB: A0A1I8MDA0_MUSDO
Original site: A0A1I8MDA0_MUSDO 
ID   A0A1I8MDA0_MUSDO        Unreviewed;      5109 AA.
AC   A0A1I8MDA0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   25-APR-2018, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:MDOA003721-PJ};
GN   Name=101888405 {ECO:0000313|VectorBase:MDOA003721-PJ};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003721-PJ};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003721-PJ}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA003721-PJ};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA003721-PJ}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA003721-PJ};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   RefSeq; XP_011296556.1; XM_011298254.2.
DR   GeneID; 101888405; -.
DR   VectorBase; MDOA003721-RJ; MDOA003721-PJ; MDOA003721.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4440   4460       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4635   4653       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4715   4737       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4904   4926       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4980   5003       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    268       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      274    332       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      340    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      581    807       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1036   1221       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1452   1673       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      464    484       {ECO:0000256|SAM:Coils}.
FT   COILED     3785   3805       {ECO:0000256|SAM:Coils}.
FT   COILED     4572   4592       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5109 AA;  579013 MW;  ECFBA25B494002DA CRC64;
     MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNVPPDLS
     QCVFVIEQAL SVRALQELVT AAGSETDRQF GKGTGSGHRT LLYGNAILLR HNNSDMYLAC
     LSTSSSNDKL SFDVGLQEHS QGEACWWTVH PASKQRSEGE KVRVGDDLIL VSVATERYLH
     TTKENEQSIV NASFHVTHWS VQPYGTGISR MKYVGYVFGG DVLRFFHGGD ECLTIPSTWG
     REAGQNIVVY EGGSVMSQAR SLWRLELART KWTGGFINWF HPMRIRHITT GRYLGVNDNN
     ELILVKKEEA SIATTTFCLR QEKDDEKKVL EDKDLEVIGS PIIKYGDTTV IVQHCETSLW
     LSYKSYETKK KGVGKVEEKQ AILHEEGKMD DCLDFSRSQE EESKTARVIR KCSSLFTQFI
     NALETLQNNR RHSIFFQKVN LNEMVMCLED LINYFSQPPD DMEHEEKQNR FRALRNRQDL
     FQEEGVLNLI LEAIDKINII TSQGFLASFL AGDEMGQSWD LISTYLYQLL AAIIQGNHTN
     CAQFANSNRL NWLFSRLGSQ ASSEGSGMLD VLHCVLIDSP EALNMMRDEH IKVIISLLEK
     HGRDPKVLDV LCSLCVGNGV AVRSSQNNIC DFLLPGKNLL LQTQLVDHVA SIRPNIFVGR
     VENSAMYQKW YFEVTMDHIE QTTHMMPHLR IGWANTAGYV PYPGGGKKWG GNGVGDDLYS
     FGFDGAYLWT GGRKTLVTDV IPEEPYIRKG DVIGVTIDLS IPIITFTFNG LKVKGCFRDF
     NLDGMFFPVM SCSSKLSCRF LFGGDHGRLK FAPPPGFSPL VQCLMPHQIL SLDPCFYFGN
     LTKNVLAGPW MIEDDTAFVP NPVDTSGVTL PSSVDQIKEK LAENIHEMWA LNKIEAGWSW
     GEHRDDYHRI HPCLTQFEKL PPAEKRYDNQ LAVQTLKTII ALGYYITMDK PPARIRPIRL
     PNEIFMQANG YKPAPLDLSA VTLTPKLEEL VDQLAENTHN LWARERIQQG WTYGLNEDSE
     NLRSPHLVPY SKVDEAIKKA NRDTASETVR TLLVYGYVLD PPTGEGNEAL LAEALRLKFA
     AFRTYRVERN YAVTSGKWYF EFEVLTSGPM RVGWARADCN PGAMLGSEDT SWAFDGHNEE
     KVFGGVSESF GKQCGPGDIV GVFLDLADHT ISFSLNGELL MDALGGETTF ADVTAEGVGF
     VPACTLGVGQ KARLIYGQDV DSLRFFTTCG LQEGYEPFCV NMRRPVTHWY TKDQPIFENT
     EEMPDCRIDV TRIPGGSDTP PHLKISHNTF ETMEKANWEF LRLSLPVTCM GEFISEAEKA
     RRWEEIKMRQ YRLMREAQEI AQQQTSAHMD HMLKSGFSMN DIKGLNRNYD DTAEADENMA
     RSPARPPRRA SMTRNITFES DLGVSEELQR STSALDMNGI EDGGAMDDKK KRGRSPFKFF
     SKKTRDQSKD KLPGRAPEVS PERRTAMTQG RSAAASQLTA KAPSLRLNNT EMPQTPTQGP
     KALSGGNLGQ PAVESSGDEM FDAECLKLIN EYFYGVRIFP GQDPTHVYVG WVTTQYHLHS
     KEFNKDKVRR GSVIIEDDYE MPIERINRQS CYVVRADELF NEVTQDASGK GASQGMFVGC
     FVDTATGMIS FTCEGKPTSH RWQMEPNTKL FPAIFVEATS KEILQIELGR TATTLPLSAA
     VLPTSDKHIN PQSPPRLKVQ CLRPHQWARV PNTALQVHAL KLSDIRGWSM LCEDPVSMLA
     LHIPEEDRCI DILELIEMDK LLSFHAHTLT LYAALCYQSN YRAAHALCQH VDQKQLLYAI
     RSEYMSGPLR QGFYDLLIAL HLESHATTME ACKMEYIIPL GPELKFLYDD EEMRHSLRSL
     VTESVRPQMR MTEITEPIPD IDHLYSPKFP LEVVREFVME ALKEAVEINQ VHNRDPIGWT
     NENLFLPLLK LTDRLFLVGV MTDEDVQKLL VMIDPETWDP SFEKDGKDEH RKGLLTMKMA
     EGAKLQMCYL LHHLYDIQLR HRVESIIAFS HDFVGDLQAD QLRRYIEIKQ SDLPSAVAAK
     KTKEFRCPPR EQMNQILCFK NLEPDDHENC TCGLELRGSL YDFHDSLMKK VSLNALQEPD
     EAESTAVEEV KTGPITKIYN FINTVKELEE GPKEVEEPEK KTPEEVFRKV LIKTIVSWAE
     ESQIETPKLV REMFSLLVRQ YDTVGELVRA LEKTYVINNK ARDDVAEMWV GLSQIRALLP
     VQMSQEEEEL MRKRLWKLVN NATFFQHPDL IRILRIHENV MAVMMNTLGR RAQAQSDAPA
     QQEGMEGAPP KEKDTSHEMV VACCRFLCYF CRTGRQNQKA MFDHFDFLLD NANILLARPS
     LRGSTPLDVA YSSLMENTEL ALALREHYLE KIAVYLSRCG LQSNSELVEK GYPDLGWDPV
     EGERYLDFLR YCVWVNGESV EENANLVIRL LIRRPECLGP ALRGEGEGLF RAIVEANRMS
     ERISDRYKMQ DEAEGTIAGL NFSHPLPEGD EDEDYIDTGA AILNFYCTLV DLLGRCAPDA
     SVIEQGKNES LRARAILRSL VPLEDLQGVL SLKFTLTQTA PGEEKPKSDM PSGLLPNNKQ
     SIVLFLERVY GIETQELFYR LLEDAFLPDL RTATILDKSD GSESDMALSM NRYIGNSILP
     LLIKHSKFYN EAENYASLLD ATLHTVYRLS KNRMLTKGQR EAVSDFLVAL TSQMQPAMLL
     KLLRKLTVDV SKLSEYTTVA LRLLTLHFDR CAKYYGSSQG QGSYGAASDE EKRLTMLLFS
     NIFDSLSNMD YDPELFGKAL PCLIAIGCAL PPDYSLSKNS DEDYYGRQSG APDQPQYDPN
     PIETSNVNLT HDYNSLVEKF SEHYHDAWAS RRLESGWTYG EVRSDTDRKH PRLKPCNMLT
     EYERERYRDP VRECLKALLA LGWTIEHSEI EVPQNNRGST RRQSKPQINE GSSFNYNPHP
     VDMTNLTLSR EMQNMAERLA ENSHDIWAKK KKEELNSCGG VIHPQLVPYD LLTDKEKRKD
     RERSQEFLKY MQYQGYKLHK PSKGGALEGE GGATQASAEL RFSYSLLEKL IQYLDRATIN
     MKLLKPSTTF SRRTSFKTAS RDIKFFSKVV LPLMEKYFST HRNYFIAVAT ATNNVGAASL
     KEKEMVAAIF CKLASLLRNR LTAFGPDVRI TVRCLQVLVK GIDARTLVKN CPEFIRTSML
     TFFNQTADDL GNTILNLQDG KYSHLRGTHL KTSTSLGYIN QVVMPVLTAM FDHLAACDYG
     SDLLLDEIQV ASYKILAALY HLGTDGSLTQ DRKYLKTEIE RHRPALGSCL GAFSSCFPVA
     FFEPHLNKHN QFSLLNRIAD HSLEAQDIMV KMESCMPNLE TVLAEVDQFV ESDKTYHDAP
     HVIDVILPLL CSYLPFWWSQ GPDNVSPTSG NHVTMVTADH MNSLLRNVLK MIKKNIGNDN
     APWMTRIAAY TQQIIINTSE ELLKDPFLPL AERVKKRTEN MFHKEESMRG FIKSATDDTS
     QVETQLQEDW NLLVRDIYSF YPLLIKYVDL QRNHWLKDNI PEAEELYNHV AEIFNIWSKS
     QYFLKEEQNF ISANEIDNMA LIMPTATRRS AITEGAPVTG GKVKKKKKNR DKKRDKDKEI
     QASLMVACLK RLLPVGLNLF AGREQELVQH CKDRYLKKMP EYDVIEFARN QLTLPDKLDP
     SDEMSWQHYL YSKLGKKEEP TEEQTAIEKA ANQNDKGRDK TQETVDRIVA MAKVLYGLHM
     IDHPQQQSKN VYRSVVSIQR KRAVIACFRQ TSLHSLPRHR ACNIFARTYY EQWLQEENVG
     QEVMIEDLTQ TFEDFEKSKK DEDETEAKPD PLTQLVTTFC RGAMTERSGA LQEDPLYMSY
     AQIAAKSCGE EEEEGGDEEG GEEEGEGTSI HEQEMEKQKL LFHQARLSNR GVAEMVLLHI
     SASKGIPSEM VMTTLNLGIS ILRGGNIDIQ MGMLNHLKEK KDVGFFTSIA GLMNSCSVLD
     LDAFERNTKA EGLGVGSEGA AGEKNMHDAE FTCALFRFIQ LTCEGHNLEW QNYLRTQAGN
     TTTVNVVICT VDYLLRLQES IMDFYWHYSS KEIIDPAGKA NFFKAIGVAS QVFNTLTEVI
     QGPCTLNQQA LAHSRLWDAV GGFLFLFSHM QEKLSKHSSQ VDLLKELLNL QKDMITMMLS
     MLEGNVVNGT IGKQMVDTLV ESAGNVELIL KYFDMFLKLK DLIESPSFME IDIKNEGWVT
     PKDFRDKMEQ SKNYTPEEID FLLACCERNH EGKIDYAGFV DRFHEPSKEI GFNLAVLLTN
     LSEHMPNEPR LARFLETAGS VLNYFEPFLG RIEILGSSKR IERVYFEIKD SNIEQWEKPQ
     IRESKRAFFY SIVTEGGDKE KLEAFVNFCE DAIFEMTHAS GLMATDDGGG NVKRDTSYSS
     YMSEEEEERA ARDPIRRTIN AVKEGLKFGV HMLSPSNIKH QIGVMQTKTV PELIIGFFKI
     IFYMFYYTGY AHFAVVRYIF GILMNLMRGP APEEVEEAPV EEETFGRALP PLPIEEPPGT
     VQAFGLDINK EENGQYKVTV HESSGGSPSS SMEETGESSP EDGGPAGEVP VEGEAHHPEP
     VSIVDLLGGE AAKKAAQERQ EAQKAQEAAM ASIEAEAKKS SSAPQETPAV NQIDFSQYTH
     RAVSFLARNF YNLKYVALVL AFSINFMLLF YKVTSLTDDE ESSGDDVLIL GSGSGAGLAG
     SGMGSGDGSG DGEGEEDEIP EMVHVDEDFF YMEHVIRIAA LMHSLVSLAM LIAYYHLKVP
     LAIFKREKEI ARRLEFDGLF IAEQPEDDDF KSHWDKLVIS AKSFPVNYWD KFVKKKVRQK
     YSETFDFDNI SNLLGMEKSS FMAQESEEGG LIKYITNIDW RYQVWKAGVT FTDNAFLYSL
     WYFSFSVMGN FNNFFFAAHL LDVAVGFKTL RTILQSVTHN GKQLVLTVML LTIIVYIYTV
     IAFNFFRKFY IQEEDEEVDK KCHDMLTCFV FHLYKGVRAG GGIGDEIGDP VGDEYEVYRI
     IFDITFFFFV IVILLAIIQG LIIDAFGELR DQLESVKENM ESNCFICGMG KDFFDIVPHG
     FDTHVQKEHN LANYMFFLMH LINKPDTEYT GQETYVWNMY QQRSWDFFPV GDCFRKQYED
     ELSGGGGGG
//
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