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Database: UniProt
Entry: A0A1I8MDA3_MUSDO
LinkDB: A0A1I8MDA3_MUSDO
Original site: A0A1I8MDA3_MUSDO 
ID   A0A1I8MDA3_MUSDO        Unreviewed;      5117 AA.
AC   A0A1I8MDA3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   25-APR-2018, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:MDOA003721-PP};
GN   Name=101888405 {ECO:0000313|VectorBase:MDOA003721-PP};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003721-PP};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003721-PP}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA003721-PP};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA003721-PP}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA003721-PP};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   VectorBase; MDOA003721-RP; MDOA003721-PP; MDOA003721.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4448   4468       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4643   4661       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4723   4745       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4912   4934       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4988   5011       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    148       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      155    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      577    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1032   1217       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1448   1669       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      460    480       {ECO:0000256|SAM:Coils}.
FT   COILED     3785   3805       {ECO:0000256|SAM:Coils}.
FT   COILED     4580   4600       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5117 AA;  579760 MW;  F789179507A51713 CRC64;
     MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNVPPDLS
     QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHNNS DMYLACLSTS
     SSNDKLSFDV GLQEHSQGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE
     NEQSIVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWGREAG
     QNIVVYEGGS VMSQARSLWR LELARTKWTG GFINWFHPMR IRHITTGRYL GVNDNNELIL
     VKKEEASIAT TTFCLRQEKD DEKKVLEDKD LEVIGSPIIK YGDTTVIVQH CETSLWLSYK
     SYETKKKGVG KVEEKQAILH EEGKMDDCLD FSRSQEEESK TARVIRKCSS LFTQFINALE
     TLQNNRRHSI FFQKVNLNEM VMCLEDLINY FSQPPDDMEH EEKQNRFRAL RNRQDLFQEE
     GVLNLILEAI DKINIITSQG FLASFLAGDE MGQSWDLIST YLYQLLAAII QGNHTNCAQF
     ANSNRLNWLF SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
     PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTQ LVDHVASIRP NIFVGRVENS
     AMYQKWYFEV TMDHIEQTTH MMPHLRIGWA NTAGYVPYPG GGKKWGGNGV GDDLYSFGFD
     GAYLWTGGRK TLVTDVIPEE PYIRKGDVIG VTIDLSIPII TFTFNGLKVK GCFRDFNLDG
     MFFPVMSCSS KLSCRFLFGG DHGRLKFAPP PGFSPLVQCL MPHQILSLDP CFYFGNLTKN
     VLAGPWMIED DTAFVPNPVD TSGVTLPSSV DQIKEKLAEN IHEMWALNKI EAGWSWGEHR
     DDYHRIHPCL TQFEKLPPAE KRYDNQLAVQ TLKTIIALGY YITMDKPPAR IRPIRLPNEI
     FMQANGYKPA PLDLSAVTLT PKLEELVDQL AENTHNLWAR ERIQQGWTYG LNEDSENLRS
     PHLVPYSKVD EAIKKANRDT ASETVRTLLV YGYVLDPPTG EGNEALLAEA LRLKFAAFRT
     YRVERNYAVT SGKWYFEFEV LTSGPMRVGW ARADCNPGAM LGSEDTSWAF DGHNEEKVFG
     GVSESFGKQC GPGDIVGVFL DLADHTISFS LNGELLMDAL GGETTFADVT AEGVGFVPAC
     TLGVGQKARL IYGQDVDSLR FFTTCGLQEG YEPFCVNMRR PVTHWYTKDQ PIFENTEEMP
     DCRIDVTRIP GGSDTPPHLK ISHNTFETME KANWEFLRLS LPVTCMGEFI SEAEKARRWE
     EIKMRQYRLM REAQEIAQQQ TSAHMDHMLK SGFSMNDIKG LNRNYDDTAE ADENMARSPA
     RPPRRASMTR NITFESDLGV SEELQRSTSA LDMNGIEDGG AMDDKKKRGR SPFKFFSKKT
     RDQSKDKLPG RAPEVSPERR TAMTQGRSAA ASQLTAKAPS LRLNNTEMPQ TPTQGPKALS
     GGNLGQPAVE SSGDEMFDAE CLKLINEYFY GVRIFPGQDP THVYVGWVTT QYHLHSKEFN
     KDKVRRGSVI IEDDYEMPIE RINRQSCYVV RADELFNEVT QDASGKGASQ GMFVGCFVDT
     ATGMISFTCE GKPTSHRWQM EPNTKLFPAI FVEATSKEIL QIELGRTATT LPLSAAVLPT
     SDKHINPQSP PRLKVQCLRP HQWARVPNTA LQVHALKLSD IRGWSMLCED PVSMLALHIP
     EEDRCIDILE LIEMDKLLSF HAHTLTLYAA LCYQSNYRAA HALCQHVDQK QLLYAIRSEY
     MSGPLRQGFY DLLIALHLES HATTMEACKM EYIIPLGPEL KFLYDDEEMR HSLRSLVTES
     VRPQMRMTEI TEPIPDIDHL YSPKFPLEVV REFVMEALKE AVEINQVHNR DPIGWTNENL
     FLPLLKLTDR LFLVGVMTDE DVQKLLVMID PETWDPSFEK DGKDEHRKGL LTMKMAEGAK
     LQMCYLLHHL YDIQLRHRVE SIIAFSHDFV GDLQADQLRR YIEIKQSDLP SAVAAKKTKE
     FRCPPREQMN QILCFKNLEP DDHENCTCGL ELRGSLYDFH DSLMKKVSLN ALQEPDEAES
     TAVEEVKTGP ITKIYNFINT VKELEEGPKE VEEPEKKTPE EVFRKVLIKT IVSWAEESQI
     ETPKLVREMF SLLVRQYDTV GELVRALEKT YVINNKARDD VAEMWVGLSQ IRALLPVQMS
     QEEEELMRKR LWKLVNNATF FQHPDLIRIL RIHENVMAVM MNTLGRRAQA QSDAPAQQEG
     MEGAPPKEKD TSHEMVVACC RFLCYFCRTG RQNQKAMFDH FDFLLDNANI LLARPSLRGS
     TPLDVAYSSL MENTELALAL REHYLEKIAV YLSRCGLQSN SELVEKGYPD LGWDPVEGER
     YLDFLRYCVW VNGESVEENA NLVIRLLIRR PECLGPALRG EGEGLFRAIV EANRMSERIS
     DRYKMQDEAE GTIAGLNFSH PLPEGDEDED YIDTGAAILN FYCTLVDLLG RCAPDASVIE
     QGKNESLRAR AILRSLVPLE DLQGVLSLKF TLTQTAPGEE KPKSDMPSGL LPNNKQSIVL
     FLERVYGIET QELFYRLLED AFLPDLRTAT ILDKSDGSES DMALSMNRYI GNSILPLLIK
     HSKFYNEAEN YASLLDATLH TVYRLSKNRM LTKGQREAVS DFLVALTSQM QPAMLLKLLR
     KLTVDVSKLS EYTTVALRLL TLHFDRCAKY YGSSQGQGSY GAASDEEKRL TMLLFSNIFD
     SLSNMDYDPE LFGKALPCLI AIGCALPPDY SLSKNSDEDY YGRQSGAPDQ PQYDPNPIET
     SNVNLTHDYN SLVEKFSEHY HDAWASRRLE SGWTYGEVRS DTDRKHPRLK PCNMLTEYER
     ERYRDPVREC LKALLALGWT IEHSEIEVPQ NNRGSTRRQS KPQINDFQNE GSSFNYNPHP
     VDMTNLTLSR EMQNMAERLA ENSHDIWAKK KKEELNSCGG VIHPQLVPYD LLTDKEKRKD
     RERSQEFLKY MQYQGYKLHK PSKGGALEGE GGATQASAEL RFSYSLLEKL IQYLDRATIN
     MKLLKPSTTF SRRTSFKTAS RDIKFFSKVV LPLMEKYFST HRNYFIAVAT ATNNVGAASL
     KEKEMVAAIF CKLASLLRNR LTAFGPDVRI TVRCLQVLVK GIDARTLVKN CPEFIRTSML
     TFFNQTADDL GNTILNLQDG KYSHLRGTHL KTSTSLGYIN QVVMPVLTAM FDHLAACDYG
     SDLLLDEIQV ASYKILAALY HLGTDGSLTQ DRKYLKTEIE RHRPALGSCL GAFSSCFPVA
     FFEPHLNKHN QFSLLNRIAD HSLEAQDIMV KMESCMPNLE TVLAEVDQFV ESDKTYHDAP
     HVIDVILPLL CSYLPFWWSQ GPDNVSPTSG NHVTMVTADH MNSLLRNVLK MIKKNIGNDN
     APWMTRIAAY TQQIIINTSE ELLKDPFLPL AERVKKRTEN MFHKEESMRG FIKSATDDTS
     QVETQLQEDW NLLVRDIYSF YPLLIKYVDL QRNHWLKDNI PEAEELYNHV AEIFNIWSKS
     QYFLKEEQNF ISANEIDNMA LIMPTATRRS AITEGAPVTG GKVKKKKKNR DKKRDKDKEI
     QASLMVACLK RLLPVGLNLF AGREQELVQH CKDRYLKKMP EYDVIEFARN QLTLPDKLDP
     SDEMSWQHYL YSKLGKKEEP TEEQTAIEKA ANQNDKGRDK TQETVDRIVA MAKVLYGLHM
     IDHPQQQSKN VYRSVVSIQR KRAVIACFRQ TSLHSLPRHR ACNIFARTYY EQWLQEENVG
     QEVMIEDLTQ TFEDFEKSKK DEDETEAKPD PLTQLVTTFC RGAMTERSGA LQEDPLYMSY
     AQIAAKSCGE EEEEGGDEEG GEEEGEGTSI HEQEMEKQKL LFHQARLSNR GVAEMVLLHI
     SASKGIPSEM VMTTLNLGIS ILRGGNIDIQ MGMLNHLKEK KDVGFFTSIA GLMNSCSVLD
     LDAFERNTKA EEYIPSAGAG LGVGSEGAAG EKNMHDAEFT CALFRFIQLT CEGHNLEWQN
     YLRTQAGNTT TVNVVICTVD YLLRLQESIM DFYWHYSSKE IIDPAGKANF FKAIGVASQV
     FNTLTEVIQG PCTLNQQALA HSRLWDAVGG FLFLFSHMQE KLSKHSSQVD LLKELLNLQK
     DMITMMLSML EGNVVNGTIG KQMVDTLVES AGNVELILKY FDMFLKLKDL IESPSFMEID
     IKNEGWVTPK DFRDKMEQSK NYTPEEIDFL LACCERNHEG KIDYAGFVDR FHEPSKEIGF
     NLAVLLTNLS EHMPNEPRLA RFLETAGSVL NYFEPFLGRI EILGSSKRIE RVYFEIKDSN
     IEQWEKPQIR ESKRAFFYSI VTEGGDKEKL EAFVNFCEDA IFEMTHASGL MATDDGGGNV
     KRDTSYSSYM SEEEEERAAR DPIRRTINAV KEGLKFGVHM LSPSNIKHQI GVMQTKTVPE
     LIIGFFKIIF YMFYYTGYAH FAVVRYIFGI LMNLMRGPAP EEVEEAPVEE ETFGRALPPL
     PIEEPPGTVQ AFGLDINKEE NGQYKVTVHE SSGGSPSSSM EETGESSPED GGPAGEVPVE
     GEAHHPEPVS IVDLLGGEAA KKAAQERQEA QKAQEAAMAS IEAEAKKSSS APQETPAVNQ
     IDFSQYTHRA VSFLARNFYN LKYVALVLAF SINFMLLFYK VTSLTDDEES SGDDVLILGS
     GSGAGLAGSG MGSGDGSGDG EGEEDEIPEM VHVDEDFFYM EHVIRIAALM HSLVSLAMLI
     AYYHLKVPLA IFKREKEIAR RLEFDGLFIA EQPEDDDFKS HWDKLVISAK SFPVNYWDKF
     VKKKVRQKYS ETFDFDNISN LLGMEKSSFM AQESEEGGLI KYITNIDWRY QVWKAGVTFT
     DNAFLYSLWY FSFSVMGNFN NFFFAAHLLD VAVGFKTLRT ILQSVTHNGK QLVLTVMLLT
     IIVYIYTVIA FNFFRKFYIQ EEDEEVDKKC HDMLTCFVFH LYKGVRAGGG IGDEIGDPVG
     DEYEVYRIIF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ LESVKENMES NCFICGMGKD
     FFDIVPHGFD THVQKEHNLA NYMFFLMHLI NKPDTEYTGQ ETYVWNMYQQ RSWDFFPVGD
     CFRKQYEDEL SGGGGGG
//
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