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Database: UniProt
Entry: A0A1I8MDA5_MUSDO
LinkDB: A0A1I8MDA5_MUSDO
Original site: A0A1I8MDA5_MUSDO 
ID   A0A1I8MDA5_MUSDO        Unreviewed;      5113 AA.
AC   A0A1I8MDA5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   25-APR-2018, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:MDOA003721-PM};
GN   Name=101888405 {ECO:0000313|VectorBase:MDOA003721-PM};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003721-PM};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003721-PM}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA003721-PM};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA003721-PM}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA003721-PM};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   RefSeq; XP_011296555.1; XM_011298253.2.
DR   GeneID; 101888405; -.
DR   VectorBase; MDOA003721-RM; MDOA003721-PM; MDOA003721.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4444   4464       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4639   4657       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4719   4741       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4908   4930       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4984   5007       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    268       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      274    332       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      340    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      581    807       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1036   1221       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1452   1673       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      464    484       {ECO:0000256|SAM:Coils}.
FT   COILED     3789   3809       {ECO:0000256|SAM:Coils}.
FT   COILED     4576   4596       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5113 AA;  579517 MW;  67EBC5FE0716D1A4 CRC64;
     MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNVPPDLS
     QCVFVIEQAL SVRALQELVT AAGSETDRQF GKGTGSGHRT LLYGNAILLR HNNSDMYLAC
     LSTSSSNDKL SFDVGLQEHS QGEACWWTVH PASKQRSEGE KVRVGDDLIL VSVATERYLH
     TTKENEQSIV NASFHVTHWS VQPYGTGISR MKYVGYVFGG DVLRFFHGGD ECLTIPSTWG
     REAGQNIVVY EGGSVMSQAR SLWRLELART KWTGGFINWF HPMRIRHITT GRYLGVNDNN
     ELILVKKEEA SIATTTFCLR QEKDDEKKVL EDKDLEVIGS PIIKYGDTTV IVQHCETSLW
     LSYKSYETKK KGVGKVEEKQ AILHEEGKMD DCLDFSRSQE EESKTARVIR KCSSLFTQFI
     NALETLQNNR RHSIFFQKVN LNEMVMCLED LINYFSQPPD DMEHEEKQNR FRALRNRQDL
     FQEEGVLNLI LEAIDKINII TSQGFLASFL AGDEMGQSWD LISTYLYQLL AAIIQGNHTN
     CAQFANSNRL NWLFSRLGSQ ASSEGSGMLD VLHCVLIDSP EALNMMRDEH IKVIISLLEK
     HGRDPKVLDV LCSLCVGNGV AVRSSQNNIC DFLLPGKNLL LQTQLVDHVA SIRPNIFVGR
     VENSAMYQKW YFEVTMDHIE QTTHMMPHLR IGWANTAGYV PYPGGGKKWG GNGVGDDLYS
     FGFDGAYLWT GGRKTLVTDV IPEEPYIRKG DVIGVTIDLS IPIITFTFNG LKVKGCFRDF
     NLDGMFFPVM SCSSKLSCRF LFGGDHGRLK FAPPPGFSPL VQCLMPHQIL SLDPCFYFGN
     LTKNVLAGPW MIEDDTAFVP NPVDTSGVTL PSSVDQIKEK LAENIHEMWA LNKIEAGWSW
     GEHRDDYHRI HPCLTQFEKL PPAEKRYDNQ LAVQTLKTII ALGYYITMDK PPARIRPIRL
     PNEIFMQANG YKPAPLDLSA VTLTPKLEEL VDQLAENTHN LWARERIQQG WTYGLNEDSE
     NLRSPHLVPY SKVDEAIKKA NRDTASETVR TLLVYGYVLD PPTGEGNEAL LAEALRLKFA
     AFRTYRVERN YAVTSGKWYF EFEVLTSGPM RVGWARADCN PGAMLGSEDT SWAFDGHNEE
     KVFGGVSESF GKQCGPGDIV GVFLDLADHT ISFSLNGELL MDALGGETTF ADVTAEGVGF
     VPACTLGVGQ KARLIYGQDV DSLRFFTTCG LQEGYEPFCV NMRRPVTHWY TKDQPIFENT
     EEMPDCRIDV TRIPGGSDTP PHLKISHNTF ETMEKANWEF LRLSLPVTCM GEFISEAEKA
     RRWEEIKMRQ YRLMREAQEI AQQQTSAHMD HMLKSGFSMN DIKGLNRNYD DTAEADENMA
     RSPARPPRRA SMTRNITFES DLGVSEELQR STSALDMNGI EDGGAMDDKK KRGRSPFKFF
     SKKTRDQSKD KLPGRAPEVS PERRTAMTQG RSAAASQLTA KAPSLRLNNT EMPQTPTQGP
     KALSGGNLGQ PAVESSGDEM FDAECLKLIN EYFYGVRIFP GQDPTHVYVG WVTTQYHLHS
     KEFNKDKVRR GSVIIEDDYE MPIERINRQS CYVVRADELF NEVTQDASGK GASQGMFVGC
     FVDTATGMIS FTCEGKPTSH RWQMEPNTKL FPAIFVEATS KEILQIELGR TATTLPLSAA
     VLPTSDKHIN PQSPPRLKVQ CLRPHQWARV PNTALQVHAL KLSDIRGWSM LCEDPVSMLA
     LHIPEEDRCI DILELIEMDK LLSFHAHTLT LYAALCYQSN YRAAHALCQH VDQKQLLYAI
     RSEYMSGPLR QGFYDLLIAL HLESHATTME ACKMEYIIPL GPELKFLYDD EEMRHSLRSL
     VTESVRPQMR MTEITEPIPD IDHLYSPKFP LEVVREFVME ALKEAVEINQ VHNRDPIGWT
     NENLFLPLLK LTDRLFLVGV MTDEDVQKLL VMIDPETWDP SFEKDGKDEH RKGLLTMKMA
     EGAKLQMCYL LHHLYDIQLR HRVESIIAFS HDFVGDLQAD QLRRYIEIKQ SDLPSAVAAK
     KTKEFRCPPR EQMNQILCFK NLEPDDHENC TCGLELRGSL YDFHDSLMKK VSLNALQEPD
     EAESTAVEEV KTGPITKIYN FINTVKELEE GPKEVEEPEK KTPEEVFRKV LIKTIVSWAE
     ESQIETPKLV REMFSLLVRQ YDTVGELVRA LEKTYVINNK ARDDVAEMWV GLSQIRALLP
     VQMSQEEEEL MRKRLWKLVN NATFFQHPDL IRILRIHENV MAVMMNTLGR RAQAQSDAPA
     QQEGMEGAPP KEKDTSHEMV VACCRFLCYF CRTGRQNQKA MFDHFDFLLD NANILLARPS
     LRGSTPLDVA YSSLMENTEL ALALREHYLE KIAVYLSRCG LQSNSELVEK GYPDLGWDPV
     EGERYLDFLR YCVWVNGESV EENANLVIRL LIRRPECLGP ALRGEGEGLF RAIVEANRMS
     ERISDRYKMQ DEAEGTIAGL NFSHPLPEGD EDEDYIDTGA AILNFYCTLV DLLGRCAPDA
     SVIEQGKNES LRARAILRSL VPLEDLQGVL SLKFTLTQTA PGEEKPKSDM PSGLLPNNKQ
     SIVLFLERVY GIETQELFYR LLEDAFLPDL RTATILDKSD GSESDMALSM NRYIGNSILP
     LLIKHSKFYN EAENYASLLD ATLHTVYRLS KNRMLTKGQR EAVSDFLVAL TSQMQPAMLL
     KLLRKLTVDV SKLSEYTTVA LRLLTLHFDR CAKYYGSSQG QGSYGAASDE EKRLTMLLFS
     NIFDSLSNMD YDPELFGKAL PCLIAIGCAL PPDYSLSKNS DEDYYGRQSG APDQPQYDPN
     PIETSNVNLT HDYNSLVEKF SEHYHDAWAS RRLESGWTYG EVRSDTDRKH PRLKPCNMLT
     EYERERYRDP VRECLKALLA LGWTIEHSEI EVPQNNRGST RRQSKPQIND FQNEGSSFNY
     NPHPVDMTNL TLSREMQNMA ERLAENSHDI WAKKKKEELN SCGGVIHPQL VPYDLLTDKE
     KRKDRERSQE FLKYMQYQGY KLHKPSKGGA LEGEGGATQA SAELRFSYSL LEKLIQYLDR
     ATINMKLLKP STTFSRRTSF KTASRDIKFF SKVVLPLMEK YFSTHRNYFI AVATATNNVG
     AASLKEKEMV AAIFCKLASL LRNRLTAFGP DVRITVRCLQ VLVKGIDART LVKNCPEFIR
     TSMLTFFNQT ADDLGNTILN LQDGKYSHLR GTHLKTSTSL GYINQVVMPV LTAMFDHLAA
     CDYGSDLLLD EIQVASYKIL AALYHLGTDG SLTQDRKYLK TEIERHRPAL GSCLGAFSSC
     FPVAFFEPHL NKHNQFSLLN RIADHSLEAQ DIMVKMESCM PNLETVLAEV DQFVESDKTY
     HDAPHVIDVI LPLLCSYLPF WWSQGPDNVS PTSGNHVTMV TADHMNSLLR NVLKMIKKNI
     GNDNAPWMTR IAAYTQQIII NTSEELLKDP FLPLAERVKK RTENMFHKEE SMRGFIKSAT
     DDTSQVETQL QEDWNLLVRD IYSFYPLLIK YVDLQRNHWL KDNIPEAEEL YNHVAEIFNI
     WSKSQYFLKE EQNFISANEI DNMALIMPTA TRRSAITEGA PVTGGKVKKK KKNRDKKRDK
     DKEIQASLMV ACLKRLLPVG LNLFAGREQE LVQHCKDRYL KKMPEYDVIE FARNQLTLPD
     KLDPSDEMSW QHYLYSKLGK KEEPTEEQTA IEKAANQNDK GRDKTQETVD RIVAMAKVLY
     GLHMIDHPQQ QSKNVYRSVV SIQRKRAVIA CFRQTSLHSL PRHRACNIFA RTYYEQWLQE
     ENVGQEVMIE DLTQTFEDFE KSKKDEDETE AKPDPLTQLV TTFCRGAMTE RSGALQEDPL
     YMSYAQIAAK SCGEEEEEGG DEEGGEEEGE GTSIHEQEME KQKLLFHQAR LSNRGVAEMV
     LLHISASKGI PSEMVMTTLN LGISILRGGN IDIQMGMLNH LKEKKDVGFF TSIAGLMNSC
     SVLDLDAFER NTKAEGLGVG SEGAAGEKNM HDAEFTCALF RFIQLTCEGH NLEWQNYLRT
     QAGNTTTVNV VICTVDYLLR LQESIMDFYW HYSSKEIIDP AGKANFFKAI GVASQVFNTL
     TEVIQGPCTL NQQALAHSRL WDAVGGFLFL FSHMQEKLSK HSSQVDLLKE LLNLQKDMIT
     MMLSMLEGNV VNGTIGKQMV DTLVESAGNV ELILKYFDMF LKLKDLIESP SFMEIDIKNE
     GWVTPKDFRD KMEQSKNYTP EEIDFLLACC ERNHEGKIDY AGFVDRFHEP SKEIGFNLAV
     LLTNLSEHMP NEPRLARFLE TAGSVLNYFE PFLGRIEILG SSKRIERVYF EIKDSNIEQW
     EKPQIRESKR AFFYSIVTEG GDKEKLEAFV NFCEDAIFEM THASGLMATD DGGGNVKRDT
     SYSSYMSEEE EERAARDPIR RTINAVKEGL KFGVHMLSPS NIKHQIGVMQ TKTVPELIIG
     FFKIIFYMFY YTGYAHFAVV RYIFGILMNL MRGPAPEEVE EAPVEEETFG RALPPLPIEE
     PPGTVQAFGL DINKEENGQY KVTVHESSGG SPSSSMEETG ESSPEDGGPA GEVPVEGEAH
     HPEPVSIVDL LGGEAAKKAA QERQEAQKAQ EAAMASIEAE AKKSSSAPQE TPAVNQIDFS
     QYTHRAVSFL ARNFYNLKYV ALVLAFSINF MLLFYKVTSL TDDEESSGDD VLILGSGSGA
     GLAGSGMGSG DGSGDGEGEE DEIPEMVHVD EDFFYMEHVI RIAALMHSLV SLAMLIAYYH
     LKVPLAIFKR EKEIARRLEF DGLFIAEQPE DDDFKSHWDK LVISAKSFPV NYWDKFVKKK
     VRQKYSETFD FDNISNLLGM EKSSFMAQES EEGGLIKYIT NIDWRYQVWK AGVTFTDNAF
     LYSLWYFSFS VMGNFNNFFF AAHLLDVAVG FKTLRTILQS VTHNGKQLVL TVMLLTIIVY
     IYTVIAFNFF RKFYIQEEDE EVDKKCHDML TCFVFHLYKG VRAGGGIGDE IGDPVGDEYE
     VYRIIFDITF FFFVIVILLA IIQGLIIDAF GELRDQLESV KENMESNCFI CGMGKDFFDI
     VPHGFDTHVQ KEHNLANYMF FLMHLINKPD TEYTGQETYV WNMYQQRSWD FFPVGDCFRK
     QYEDELSGGG GGG
//
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