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Database: UniProt
Entry: A0A1I8MDA8_MUSDO
LinkDB: A0A1I8MDA8_MUSDO
Original site: A0A1I8MDA8_MUSDO 
ID   A0A1I8MDA8_MUSDO        Unreviewed;      5131 AA.
AC   A0A1I8MDA8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   25-APR-2018, entry version 14.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:MDOA003721-PQ};
GN   Name=101888405 {ECO:0000313|VectorBase:MDOA003721-PQ};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003721-PQ};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003721-PQ}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA003721-PQ};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA003721-PQ}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA003721-PQ};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   RefSeq; XP_011296547.1; XM_011298245.2.
DR   GeneID; 101888405; -.
DR   KEGG; mde:101888405; -.
DR   VectorBase; MDOA003721-RQ; MDOA003721-PQ; MDOA003721.
DR   KO; K04962; -.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4462   4482       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4657   4675       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4737   4759       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4926   4948       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5002   5025       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    268       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      274    332       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      340    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      581    807       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1036   1221       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1452   1673       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      464    484       {ECO:0000256|SAM:Coils}.
FT   COILED     3799   3819       {ECO:0000256|SAM:Coils}.
FT   COILED     4594   4614       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5131 AA;  581305 MW;  3AC90313173580AE CRC64;
     MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNVPPDLS
     QCVFVIEQAL SVRALQELVT AAGSETDRQF GKGTGSGHRT LLYGNAILLR HNNSDMYLAC
     LSTSSSNDKL SFDVGLQEHS QGEACWWTVH PASKQRSEGE KVRVGDDLIL VSVATERYLH
     TTKENEQSIV NASFHVTHWS VQPYGTGISR MKYVGYVFGG DVLRFFHGGD ECLTIPSTWG
     REAGQNIVVY EGGSVMSQAR SLWRLELART KWTGGFINWF HPMRIRHITT GRYLGVNDNN
     ELILVKKEEA SIATTTFCLR QEKDDEKKVL EDKDLEVIGS PIIKYGDTTV IVQHCETSLW
     LSYKSYETKK KGVGKVEEKQ AILHEEGKMD DCLDFSRSQE EESKTARVIR KCSSLFTQFI
     NALETLQNNR RHSIFFQKVN LNEMVMCLED LINYFSQPPD DMEHEEKQNR FRALRNRQDL
     FQEEGVLNLI LEAIDKINII TSQGFLASFL AGDEMGQSWD LISTYLYQLL AAIIQGNHTN
     CAQFANSNRL NWLFSRLGSQ ASSEGSGMLD VLHCVLIDSP EALNMMRDEH IKVIISLLEK
     HGRDPKVLDV LCSLCVGNGV AVRSSQNNIC DFLLPGKNLL LQTQLVDHVA SIRPNIFVGR
     VENSAMYQKW YFEVTMDHIE QTTHMMPHLR IGWANTAGYV PYPGGGKKWG GNGVGDDLYS
     FGFDGAYLWT GGRKTLVTDV IPEEPYIRKG DVIGVTIDLS IPIITFTFNG LKVKGCFRDF
     NLDGMFFPVM SCSSKLSCRF LFGGDHGRLK FAPPPGFSPL VQCLMPHQIL SLDPCFYFGN
     LTKNVLAGPW MIEDDTAFVP NPVDTSGVTL PSSVDQIKEK LAENIHEMWA LNKIEAGWSW
     GEHRDDYHRI HPCLTQFEKL PPAEKRYDNQ LAVQTLKTII ALGYYITMDK PPARIRPIRL
     PNEIFMQANG YKPAPLDLSA VTLTPKLEEL VDQLAENTHN LWARERIQQG WTYGLNEDSE
     NLRSPHLVPY SKVDEAIKKA NRDTASETVR TLLVYGYVLD PPTGEGNEAL LAEALRLKFA
     AFRTYRVERN YAVTSGKWYF EFEVLTSGPM RVGWARADCN PGAMLGSEDT SWAFDGHNEE
     KVFGGVSESF GKQCGPGDIV GVFLDLADHT ISFSLNGELL MDALGGETTF ADVTAEGVGF
     VPACTLGVGQ KARLIYGQDV DSLRFFTTCG LQEGYEPFCV NMRRPVTHWY TKDQPIFENT
     EEMPDCRIDV TRIPGGSDTP PHLKISHNTF ETMEKANWEF LRLSLPVTCM GEFISEAEKA
     RRWEEIKMRQ YRLMREAQEI AQQQTSAHMD HMLKSGFSMN DIKGLNRNYD DTAEADENMA
     RSPARPPRRA SMTRNITFES DLGVSEELQR STSALDMNGI EDGGAMDDKK KRGRSPFKFF
     SKKTRDQSKD KLPGRAPEVS PERRTAMTQG RSAAASQLTA KAPSLRLNNT EMPQTPTQGP
     KALSGGNLGQ PAVESSGDEM FDAECLKLIN EYFYGVRIFP GQDPTHVYVG WVTTQYHLHS
     KEFNKDKVRR GSVIIEDDYE MPIERINRQS CYVVRADELF NEVTQDASGK GASQGMFVGC
     FVDTATGMIS FTCEGKPTSH RWQMEPNTKL FPAIFVEATS KEILQIELGR TATTLPLSAA
     VLPTSDKHIN PQSPPRLKVQ CLRPHQWARV PNTALQVHAL KLSDIRGWSM LCEDPVSMLA
     LHIPEEDRCI DILELIEMDK LLSFHAHTLT LYAALCYQSN YRAAHALCQH VDQKQLLYAI
     RSEYMSGPLR QGFYDLLIAL HLESHATTME ACKMEYIIPL GPELKFLYDD EEMRHSLRSL
     VTESVRPQMR MTEITPISIQ TNASSEPIPD IDHLYSPKFP LEVVREFVME ALKEAVEINQ
     VHNRDPIGWT NENLFLPLLK LTDRLFLVGV MTDEDVQKLL VMIDPETWDP SFEKDGKDEH
     RKGLLTMKMA EGAKLQMCYL LHHLYDIQLR HRVESIIAFS HDFVGDLQAD QLRRYIEIKQ
     SDLPSAVAAK KTKEFRCPPR EQMNQILCFK NLEPDDHENC TCGLELRGSL YDFHDSLMKK
     VSLNALQEPD EAESTAVEEV KTGPITKIYN FINTVKELEE GPKEVEEPEK KTPEEVFRKV
     LIKTIVSWAE ESQIETPKLV REMFSLLVRQ YDTVGELVRA LEKTYVINNK ARDDVAEMWV
     GLSQIRALLP VQMSQEEEEL MRKRLWKLVN NATFFQHPDL IRILRIHENV MAVMMNTLGR
     RAQAQSDAPA QQEGMEGAPP KEKDTSHEMV VACCRFLCYF CRTGRQNQKA MFDHFDFLLD
     NANILLARPS LRGSTPLDVA YSSLMENTEL ALALREHYLE KIAVYLSRCG LQSNSELVEK
     GYPDLGWDPV EGERYLDFLR YCVWVNGESV EENANLVIRL LIRRPECLGP ALRGEGEGLF
     RAIVEANRMS ERISDRYKMQ DEAEGTIAGL NFSHPLPEGD EDEDYIDTGA AILNFYCTLV
     DLLGRCAPDA SVIEQGKNES LRARAILRSL VPLEDLQGVL SLKFTLTQTA PGEEKPKSDM
     PSGLLPNNKQ SIVLFLERVY GIETQELFYR LLEDAFLPDL RTATILDKSD GSESDMALSM
     NRYIGNSILP LLIKHSKFYN EAENYASLLD ATLHTVYRLS KNRMLTKGQR EAVSDFLVAL
     TSQMQPAMLL KLLRKLTVDV SKLSEYTTVA LRLLTLHFDR CAKYYGSSQG QGSYGAASDE
     EKRLTMLLFS NIFDSLSNMD YDPELFGKAL PCLIAIGCAL PPDYSLSKNS DEDYYGRQSG
     APDQPQYDPN PIETSNVNLT HDYNSLVEKF SEHYHDAWAS RRLESGWTYG EVRSDTDRKH
     PRLKPCNMLT EYERERYRDP VRECLKALLA LGWTIEHSEI EVPQNNRGST RRQSKPQIND
     FQNEGSSFNY NPHPVDMTNL TLSREMQNMA ERLAENSHDI WAKKKKEELN SCGGVIHPQL
     VPYDLLTDKE KRKDRERSQE FLKYMQYQGY KLHKPSKGGA LEGEGGATQA SAELRFSYSL
     LEKLIQYLDR ATINMKLLKP STTFSRRTSF KTASRDIKFF SKVVLPLMEK YFSTHRNYFI
     AVATATNNVG AASLKEKEMV AAIFCKLASL LRNRLTAFGP DVRITVRCLQ VLVKGIDART
     LVKNCPEFIR TSMLTFFNQT ADDLGNTILN LQDGKYSHLR GTHLKTSTSL GYINQVVMPV
     LTAMFDHLAA CDYGSDLLLD EIQVASYKIL AALYHLGTDG SLTQDRKYLK TEIERHRPAL
     GSCLGAFSSC FPVAFFEPHL NKHNQFSLLN RIADHSLEAQ DIMVKMESCM PNLETVLAEV
     DQFVESDKTY HDAPHVIDVI LPLLCSYLPF WWSQGPDNVS PTSGNHVTMV TADHMNSLLR
     NVLKMIKKNI GNDNAPWMTR IAAYTQQIII NTSEELLKDP FLPLAERVKK RTENMFHKEE
     SMRGFIKSAT DDTSQVETQL QEDWNLLVRD IYSFYPLLIK YVDLQRNHWL KDNIPEAEEL
     YNHVAEIFNI WSKSQYFLKE EQNFISANEI DNMALIMPTA TRRSAITEGA PVTGGKVKKK
     KKNRDKKRDK DKEIQASLMV ACLKRLLPVG LNLFAGREQE LVQHCKDRYL KKMPEYDVIE
     FARNQLTLPD KLDPSDEMSW QHYLYSKLGK KEEPTEEQTA IEKAANQNDK GRDKTQETVD
     RIVAMAKVLY GLHMIDHPQQ QSKNVYRSVV SIQRKRAVIA CFRQTSLHSL PRHRACNIFA
     RTYYEQWLQE ENVGQEVMIE DLTQTFEDFE KSKKDEDETE AKPDPLTQLV TTFCRGAMTE
     RSGALQEDPL YMSYAQIAAK SCGEEEEEGG DEEGGEEEGE GTSIHEQEME KQKLLFHQAR
     LSNRGVAEMV LLHISASKGI PSEMVMTTLN LGISILRGGN IDIQMGMLNH LKEKKDVGFF
     TSIAGLMNSC SVLDLDAFER NTKAEEYIPS AGAGLGVGSE GAAGEKNMHD AEFTCALFRF
     IQLTCEGHNL EWQNYLRTQA GNTTTVNVVI CTVDYLLRLQ ESIMDFYWHY SSKEIIDPAG
     KANFFKAIGV ASQVFNTLTE VIQGPCTLNQ QALAHSRLWD AVGGFLFLFS HMQEKLSKHS
     SQVDLLKELL NLQKDMITMM LSMLEGNVVN GTIGKQMVDT LVESAGNVEL ILKYFDMFLK
     LKDLIESPSF MEIDIKNEGW VTPKDFRDKM EQSKNYTPEE IDFLLACCER NHEGKIDYAG
     FVDRFHEPSK EIGFNLAVLL TNLSEHMPNE PRLARFLETA GSVLNYFEPF LGRIEILGSS
     KRIERVYFEI KDSNIEQWEK PQIRESKRAF FYSIVTEGGD KEKLEAFVNF CEDAIFEMTH
     ASGLMATDDG GGNVKRDTSY SSYMSEEEEE RAARDPIRRT INAVKEGLKF GVHMLSPSNI
     KHQIGVMQTK TVPELIIGFF KIIFYMFYYT GYAHFAVVRY IFGILMNLMR GPAPEEVEEA
     PVEEETFGRA LPPLPIEEPP GTVQAFGLDI NKEENGQYKV TVHESSGGSP SSSMEETGES
     SPEDGGPAGE VPVEGEAHHP EPVSIVDLLG GEAAKKAAQE RQEAQKAQEA AMASIEAEAK
     KSSSAPQETP AVNQIDFSQY THRAVSFLAR NFYNLKYVAL VLAFSINFML LFYKVTSLTD
     DEESSGDDVL ILGSGSGAGL AGSGMGSGDG SGDGEGEEDE IPEMVHVDED FFYMEHVIRI
     AALMHSLVSL AMLIAYYHLK VPLAIFKREK EIARRLEFDG LFIAEQPEDD DFKSHWDKLV
     ISAKSFPVNY WDKFVKKKVR QKYSETFDFD NISNLLGMEK SSFMAQESEE GGLIKYITNI
     DWRYQVWKAG VTFTDNAFLY SLWYFSFSVM GNFNNFFFAA HLLDVAVGFK TLRTILQSVT
     HNGKQLVLTV MLLTIIVYIY TVIAFNFFRK FYIQEEDEEV DKKCHDMLTC FVFHLYKGVR
     AGGGIGDEIG DPVGDEYEVY RIIFDITFFF FVIVILLAII QGLIIDAFGE LRDQLESVKE
     NMESNCFICG MGKDFFDIVP HGFDTHVQKE HNLANYMFFL MHLINKPDTE YTGQETYVWN
     MYQQRSWDFF PVGDCFRKQY EDELSGGGGG G
//
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