ID A0A1I8MDW6_MUSDO Unreviewed; 522 AA.
AC A0A1I8MDW6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC3 {ECO:0000256|RuleBase:RU367076};
DE Short=RNA polymerase III subunit C3 {ECO:0000256|RuleBase:RU367076};
GN Name=101894069 {ECO:0000313|EnsemblMetazoa:MDOA003883-PA};
GN Synonyms=LOC101894069 {ECO:0000313|RefSeq:XP_005175452.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA003883-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA003883-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA003883-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005175452.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005175452.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific core component of RNA polymerase III which synthesizes small
CC RNAs, such as 5S rRNA and tRNAs. {ECO:0000256|RuleBase:RU367076}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits. {ECO:0000256|RuleBase:RU367076}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367076}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase
CC subunit family. {ECO:0000256|ARBA:ARBA00007206,
CC ECO:0000256|RuleBase:RU367076}.
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DR RefSeq; XP_005175452.1; XM_005175395.3.
DR STRING; 7370.A0A1I8MDW6; -.
DR EnsemblMetazoa; MDOA003883-RA; MDOA003883-PA; MDOA003883.
DR GeneID; 101894069; -.
DR KEGG; mde:101894069; -.
DR VEuPathDB; VectorBase:MDOA003883; -.
DR eggNOG; KOG2587; Eukaryota.
DR OrthoDB; 2875034at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 6.10.140.1450; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 4.
DR InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR InterPro; IPR039748; RPC3.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR12949:SF0; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3; 1.
DR PANTHER; PTHR12949; RNA POLYMERASE III DNA DIRECTED -RELATED; 1.
DR Pfam; PF08221; HTH_9; 1.
DR Pfam; PF05645; RNA_pol_Rpc82; 1.
DR Pfam; PF20912; RPC3_helical; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU367076}; Nucleus {ECO:0000256|RuleBase:RU367076};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU367076}.
FT DOMAIN 7..66
FT /note="RNA polymerase III subunit RPC82-related helix-turn-
FT helix"
FT /evidence="ECO:0000259|Pfam:PF08221"
FT DOMAIN 143..324
FT /note="RNA polymerase III Rpc82 C -terminal"
FT /evidence="ECO:0000259|Pfam:PF05645"
SQ SEQUENCE 522 AA; 59568 MW; 3FD0237927664AF6 CRC64;
MSIDYGNLCS VILKQCFGET VQLVGDCLFA ANARSLGNIV KSTNLTRREV STALGILIKY
QLVTFQANDV NPFMAEYSLK RDEILYILRY SRYVHLIQTK YGSVGAAIAE ELLYSGSQTA
SNTLLKCLSN NEINEKVETI RDTFVQMIRD NYLIKLPMLV PTETGEPELV PKLHIEDYDL
FNPPEIDLAM LAKVQAGTVQ ASQLRDAAVF WQLNFKRFHQ DFRDQCMISA VERKLGSSAA
ECFKYILKQM YERTDPWQRQ CSNPFTVVEV KQVVEKNSSN LDLIRHLDQY VALLADDSLH
FIRKIGEMGG GQYVVDLAPA FESLALACIE NVITERFGSK ASRIFRVVRM KKYIEQEDLQ
KEAMVPAKEA KLLSYNLFQE QFVQIKTIRK AGGGGTGPAK AFYLFYLKYK QIAKMLLDIC
FKALYNDITR SNYEKNEHKR LIEKSQKLDS IVATMKERGE SLEYIAEILE TLTPPEREIL
DKVKNRIKTL SKAELSLDDT IFLLQMYLYH SAQVSVAPAT KK
//
