ID A0A1I8ME04_MUSDO Unreviewed; 339 AA.
AC A0A1I8ME04;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN Name=101888781 {ECO:0000313|EnsemblMetazoa:MDOA003918-PA};
GN Synonyms=LOC101888781 {ECO:0000313|RefSeq:XP_005187529.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA003918-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA003918-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA003918-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005187529.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005187529.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR RefSeq; XP_005187529.1; XM_005187472.2.
DR STRING; 7370.A0A1I8ME04; -.
DR EnsemblMetazoa; MDOA003918-RA; MDOA003918-PA; MDOA003918.
DR VEuPathDB; VectorBase:MDOA003918; -.
DR eggNOG; KOG3913; Eukaryota.
DR OrthoDB; 2874082at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0048699; P:generation of neurons; IEA:UniProt.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF91; PROTO-ONCOGENE WNT-1; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT REGION 202..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 37206 MW; D8CD7FBE4515AAF5 CRC64;
CRETGFIYAI TSAAVTHSIA RACSEGSIES CTCDYSHQTR SPQANAQAGS VAGVRDWEWG
GCSDNIGFGF KFSREFVDTG ERGRNLREKM NLHNNEAGRA HVQAEMRQEC KCHGMSGSCT
VKTCWMRLAN FRVIGDNLKD RFDGASRVMM SNSVRASGSA NAVGGANISP NAVGVSPNAL
SPNAASPNAY DEERMLNDEH VVKHHPNMPS PNSLPNQSGV SRNSVRGRQG RQGRKNNRYS
FVLKPHNPDH KPPGTKDIVY LEPSPSFCEK NLRLGIQGTH GRQCNDTSIG VDGCDLMCCG
RGYRTQEVVV VERCACTFHW CCEVKCKLCR TKKTIHTCL
//
