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Database: UniProt
Entry: A0A1I8ME14_MUSDO
LinkDB: A0A1I8ME14_MUSDO
Original site: A0A1I8ME14_MUSDO 
ID   A0A1I8ME14_MUSDO        Unreviewed;       637 AA.
AC   A0A1I8ME14;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   05-DEC-2018, entry version 16.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   Name=101890434 {ECO:0000313|VectorBase:MDOA003927-PA,
GN   ECO:0000313|VectorBase:MDOA003927-PB,
GN   ECO:0000313|VectorBase:MDOA003927-PC};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003927-PA};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA003927-PA, ECO:0000313|VectorBase:MDOA003927-PB}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA003927-PA};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA003927-PA, ECO:0000313|VectorBase:MDOA003927-PB, ECO:0000313|VectorBase:MDOA003927-PC}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA003927-PA,
RC   ECO:0000313|VectorBase:MDOA003927-PB};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   RefSeq; XP_005185049.1; XM_005184992.3.
DR   RefSeq; XP_011293144.1; XM_011294842.2.
DR   RefSeq; XP_011293145.1; XM_011294843.2.
DR   GeneID; 101890434; -.
DR   KEGG; mde:101890434; -.
DR   VectorBase; MDOA003927-RA; MDOA003927-PA; MDOA003927.
DR   VectorBase; MDOA003927-RB; MDOA003927-PB; MDOA003927.
DR   VectorBase; MDOA003927-RC; MDOA003927-PC; MDOA003927.
DR   KO; K12309; -.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 2.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    637       Beta-galactosidase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5014271552.
FT   DOMAIN       40    358       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      544    613       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
FT   ACT_SITE    188    188       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
FT   ACT_SITE    266    266       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
SQ   SEQUENCE   637 AA;  72053 MW;  5360665E760F175A CRC64;
     MHRTTLHAAL LIFAVVILGH ATDEVTAKRT FEVDWANDRF LKDGKPFRFI AGSFHYFRSH
     PDTWQRKLRT MRAAGLNAVT TYVEWSLHNP KDGVYVWDGI ANLERFIKYA IDEDLLVILR
     PGPYICAERD FGGFPYWLLS KYPNIKLRTS DINYLYEVRI WYSQLMAKMD TYLYGNGGPI
     IMVQVENEYG SYYACDKKYR AWLRDETLGH VKDKAVLFTN DGPSVLHCGH IDGVVSAMDF
     GATNNLTDIW NKLRRVQPRG PLVNAEYYPG WLTHWGEGMA RVNTKSITNT FIEMLNDGAS
     VNFYMFYGGT NFGFTAGAND GGPGRYMADI TSYDYDAPMT EAGDPTSKYY ALREIISRYL
     PMPNISVPDP VPKKKYGTIK LQSCCSLLSK AGRQQLATGV VMSNKPKSFE ALGQFSGLVL
     YETYLPNTRK DPGVLHIPGL RDRALVYVEN DFVGMLSRES VIFDLPIPLR SGKKLQILVE
     NQGRINYGPI TDAKGIIGDV AFDKKILTNW NMTKFPLESY EDIERLIQQE GSRLNEIDSY
     KMLNDGPTIF YGSFEIKDLH TCDTYLDTTG WSKGIAFVNG ENLGRYWPMV GPQVTLYVPA
     EVLKVGVNNV VLIEYQSAAA TAEITFTDKP NLDGLRN
//
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