ID A0A1I8ME82_MUSDO Unreviewed; 1395 AA.
AC A0A1I8ME82;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Uncharacterized protein LOC101895123 {ECO:0000313|RefSeq:XP_005177479.1};
GN Name=101895123 {ECO:0000313|EnsemblMetazoa:MDOA003997-PA};
GN Synonyms=LOC101895123 {ECO:0000313|RefSeq:XP_005177479.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA003997-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA003997-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA003997-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005177479.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005177479.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_005177479.1; XM_005177422.3.
DR STRING; 7370.A0A1I8ME82; -.
DR EnsemblMetazoa; MDOA003997-RA; MDOA003997-PA; MDOA003997.
DR VEuPathDB; VectorBase:MDOA003997; -.
DR eggNOG; KOG0039; Eukaryota.
DR OrthoDB; 367877at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR PANTHER; PTHR11972:SF58; NADPH OXIDASE 5; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SFLD; SFLDS00052; Ferric_Reductase_Domain; 1.
DR SFLD; SFLDG01169; NADPH_oxidase_subgroup_(NOX); 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 660..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 443..478
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 518..553
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 723..871
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..964
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1395 AA; 157738 MW; A88EC7A5B0A06964 CRC64;
MENNYKLTIN TTNAEQHRGS VSSTNSLEVP ATPTRSPKKV SFSDDLPYDN GAGDKAGSAA
NQQHNTNNHN NNALSKSSDK MINSLNLNST TTSDQQQRNT STIRPSTTTT TLEHQVQLMV
EKEPPSQNPV EFMLTQAAQY LEKMHAPNVA KVVVPQESHS KNQANDSHKF KSSLNIDLVD
GGHHQSSGNA TTTTTTNPQI ITTPTQTMSP PLNATTATTI LSYTPPSPVP AVLHLTSRSG
SISPSGLSTP STEAARSTKS STSSAESTTS LETPYKPPRS SMINSGAAAA NKSTPCNNAP
LQECSSDMQE ISEEQAEHAI KYMEGYNLNL DKNNCSAMEL EAKRDKIRWL LISECSALLG
EGKHTREGFR KQFLQEEFQK KLFHLFDLDG NGYLVQDRWI EHLKGRLTDD RQMDYAEQLE
SVAYVICGEN SKITFKNFTD IWHARGILDK LYRLIDSDGT NSISTNQIME FISHLTNSRP
RTGFDKSSLA RLEQLFRNTV GNEREIRREE FKKIVISKNP FFTERVFQIF DKDNSGSISL
QEFIDAIQQF SGQSADDKIR FLFKVYDIDG QCLNFNCAWI LVLMLRNSLT YLRSRGLSTY
LPLDNHIYLH KLTGIVVSVL SLVHTVMHLF NFSIIVVNDP QINAGHYTIG EWLLTDRPGL
FGLIPGCANP TGMALFIILL IMYICSQPFV RRKGSFEVFY WTHLLYIPFW ILVLFHGPNF
WKWFFIPGII YTVERILRFV WMRGDHGKTY ISSGLLLPSK VVHLVIKRPN NFNFRPGDYV
FVNIPVIANY EWHPFTISSA PEQEDYMWLH IRTVGEWTNR LYRYFEKEQQ RLHNGKIIAH
KQAIPTSSLL QISEENSKTI SSTPQTDFLA QNLAKIQQSS SFDSNVVAKT LQDVPTNPMR
PPRHNYTPSK LATESISASH VAEQARASNS SSGDRIRSFK KTLQRTFSRK DVASKEKRLS
GHSNDGFVTD DSDLASITEL GKRRKLKKLM GDKPPLEKSV SLPDIAVKTK RRERFKALHT
LGRSESERSF DETRIRRARL SSGFAYMSPQ NKSLAQSFRY MRNKPTIIAF KTPSVEESET
EFTPKQNHTE QTCNAIQAEE GRVSTDHSNN NKDTNHDDAD MVVSKPLEDH TNHHYNSRSS
TTTNNRVGRF RRPTFLRSLS TSIKNRGSSG SIPANGTTNS GGKVILDAGV LEIFIDGPYG
APSSHIFMAQ HAVLIGTGIG VTPFASILQS IMHRYWKARH HCPRCLFEWA SDIPKSVMNL
RKVDFFWINR DQRSFEWFVN LLSQLEIEQA ELGGAMERFL DMHMYITSAL QRTDMKAVGL
QLALDLLHEK GKRDLITGLK TRTNAGRPNW DKVFKQLQAQ KKGKVTVFYC GPPQLAKTLR
IKCDQYGFAF RKECF
//
