GenomeNet

Database: UniProt
Entry: A0A1I8MEI0_MUSDO
LinkDB: A0A1I8MEI0_MUSDO
Original site: A0A1I8MEI0_MUSDO 
ID   A0A1I8MEI0_MUSDO        Unreviewed;      3563 AA.
AC   A0A1I8MEI0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   05-JUN-2019, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:MDOA004074-PD};
GN   Name=101888489 {ECO:0000313|VectorBase:MDOA004074-PD};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA004074-PD};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA004074-PD}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA004074-PD};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:RESEARCH0466.1-RESEARCH0466.16(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA004074-PD}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA004074-PD};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   VectorBase; MDOA004074-RD; MDOA004074-PD; MDOA004074.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00033; CCP; 4.
DR   CDD; cd00041; CUB; 3.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.120.290; -; 3.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR003410; HYR_dom.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR001759; Pentraxin-related.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR   Pfam; PF00431; CUB; 3.
DR   Pfam; PF00008; EGF; 9.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF07699; Ephrin_rec_like; 7.
DR   Pfam; PF00754; F5_F8_type_C; 2.
DR   Pfam; PF12661; hEGF; 2.
DR   Pfam; PF02494; HYR; 3.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   Pfam; PF00084; Sushi; 4.
DR   SMART; SM00032; CCP; 9.
DR   SMART; SM00034; CLECT; 1.
DR   SMART; SM00042; CUB; 3.
DR   SMART; SM00181; EGF; 22.
DR   SMART; SM00179; EGF_CA; 16.
DR   SMART; SM01411; Ephrin_rec_like; 7.
DR   SMART; SM00231; FA58C; 2.
DR   SMART; SM00192; LDLa; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF49854; SSF49854; 3.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   SUPFAM; SSF57184; SSF57184; 5.
DR   SUPFAM; SSF57424; SSF57424; 1.
DR   SUPFAM; SSF57535; SSF57535; 7.
DR   PROSITE; PS00010; ASX_HYDROXYL; 11.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR   PROSITE; PS01180; CUB; 3.
DR   PROSITE; PS00022; EGF_1; 15.
DR   PROSITE; PS01186; EGF_2; 12.
DR   PROSITE; PS50026; EGF_3; 18.
DR   PROSITE; PS01187; EGF_CA; 6.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS50022; FA58C_3; 2.
DR   PROSITE; PS50825; HYR; 3.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
DR   PROSITE; PS51828; PTX_2; 1.
DR   PROSITE; PS50923; SUSHI; 8.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00438935}; Membrane {ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29   3563       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5009323118.
FT   TRANSMEM   3414   3440       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       42    167       C-type lectin. {ECO:0000259|PROSITE:
FT                                PS50041}.
FT   DOMAIN      209    321       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      325    437       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      438    550       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      549    610       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      611    671       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      672    732       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      733    791       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      791    829       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      828    976       F5/8 type C. {ECO:0000259|PROSITE:
FT                                PS50022}.
FT   DOMAIN      983   1019       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1048   1107       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1184   1247       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1297   1443       F5/8 type C. {ECO:0000259|PROSITE:
FT                                PS50022}.
FT   DOMAIN     1462   1548       HYR. {ECO:0000259|PROSITE:PS50825}.
FT   DOMAIN     1549   1632       HYR. {ECO:0000259|PROSITE:PS50825}.
FT   DOMAIN     1633   1697       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2020   2056       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2058   2094       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2096   2134       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2136   2175       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2177   2213       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2215   2250       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2252   2288       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2290   2326       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2328   2366       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2368   2404       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2406   2443       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2445   2481       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2483   2519       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2521   2557       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2798   2880       HYR. {ECO:0000259|PROSITE:PS50825}.
FT   DOMAIN     2881   2951       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3335   3372       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     3374   3409       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID    171    183       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    178    196       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    190    205       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    438    465       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID    551    594       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    674    717       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    703    730       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   1078   1105       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2046   2055       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2084   2093       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2105   2122       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2124   2133       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2165   2174       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2203   2212       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2219   2229       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2240   2249       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2278   2287       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2316   2325       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2337   2354       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2356   2365       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2394   2403       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2433   2442       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2471   2480       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2509   2518       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2547   2556       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   3339   3349       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   3343   3360       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   3377   3387       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   3399   3408       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   3563 AA;  389579 MW;  E1B9E61E3A03A7E0 CRC64;
     MGSLTAASLQ WLSAFVCLLL LSCCCVRAAD DVFSCPNGWE LRGLYCYKYF NIKHSWEKSA
     ELCRRYGAEL VAIDNYAENN NTLSIARLND PNHRASDKYW LGLASLDELR TNTLESASGA
     LISQYSGFWS LHQPNPQSGE CVAATFTSVI QSWNLGTCES LLPFMCRASA CPVNSIHCAN
     GKCVNQSFKC DGSDDCGDGS DELDCPAQCH YHMQSGGDVI ESPNYPHKYG ALSKCKWTLE
     GPLGSNIILQ FQDFETEKTF DTVQVLVGGR TEEKSVSLAT LSGKHDLTTQ PLVSASNFMI
     VKFTSDGSVE RKGFRATWKT ESKVCGGTLK ATLQRQTLTS PNYPKQYPGG LECLYIIKAQ
     PGRIISIEVD DLDIVEGRDY MLIRDGESPM SRPIAKLTGK TGTNEKVIIS TGNALYLYFK
     SSLGDSGKGF SLRYIQGCKA TITARNGTVT SPAFGLADYP KNQECYFTIR NSMGSPLSLK
     FVKFMVHKSD NVQVYDGSST SGLRLHSGDG FTGTAVPKLT LTASSGEMLI KFTSDALHNA
     AGWSATFSAD CPELQPGIGA LASSRDTAFG TVVTFTCPIG QEFATGKSKI VTECMKGGNW
     SVSYIPKCQE VYCGPVPQID NGFSIGSSNV TYRGVAMYQC YAGFTFSSGL PIEKISCLPD
     GRWERKPTCM ASQCAPLPEV PHANITLLNG GGRSYGTIVQ YECEPGYERT GHPVLTCMSN
     GTWSGEVPRC SRKRCYEFPK IENGFVVDSD RAYYYSDDAR VQCFKGYKLI GSNIIRCNSD
     QIFENPPTCE DINECTSTQC DLATTECVNT AGSFHCQCRA GFTATSECRP VGDLGLSNGG
     IPDESITTSA SEEGFSKGMV RLTSGGWCGA SAEPGANWIL IDLKAPTILR GFRTMSVQRF
     DGNIAFTSAV RLQYTDDLTD VFKDYTNPDG TAVEFRILEP TLSILNLPMP IEARYVRFRI
     QDYVGAPCIR FEAMGCTRLD CVDINECAKN NGGCDQKCVN SPGSYSCSCN TGYQLYTANG
     TAGYYVEKTE TGERDGDTYQ RNKTCVPLMC PNLEEPENGK LLTDKDTHHF GDIVNFQCNF
     GYIMSGSSSL LCLSSGQWNG SVPECNYAKC VSLPDDKMEG LSVLRPDPES VLVPFRENVS
     ITCNAPGRQL RSTASSGFRQ CVYDPKPGLP DYWLSGSQPS CPRVDCYEPM PTPGAEYGQY
     VDTRYQSNFF FGCQNTFKLA GQTSHHDNVV RCQQDGIWDF GDLRCEGPVC DDPGRPSDGR
     QIAKSYEQGS EVYFGCNRPG YILINPRPIT CIREPECKVI KPLGLTSGKI PDSAINATSE
     RPNYEAKNIR LNSATGWCGK QEAFTYVSVD LGQIYRVKAI LVKGVVTNDI VGRPTEIRFF
     YKQAENENYV VYFPNFNLTM RDPGNYGELA MITLPKYVQA RFVILGIVSY MDNACLKFEL
     MGCEEPKKEP LLGYDYGYSP CVDNEPPIFQ NCPQQPIIVK RDEFGAILPV NFTEPTAVDN
     SGSIARLEVK PQNFKTPSFI FRDTVVKYVA FDYDGNVAIC EINITVPDVT PPLLQCPQSY
     VIELAERQDR YNVNFNDTRN RIKTSDESGE VRLSFSPESA VIPIRGFENV TVTAIDKFGN
     KAFCNYQVSV QASPCVDWEL QPPANGAINC LPGDRGIECI ATCKPGFRFT DGEPIKSFSC
     ETSRLWKPTS VVPDCVSENT EQADYQVTAT ITYRANGAVA QSCLGKYQDA LAQNYAGLNQ
     LLSQRCSAVN VNMNVTFLKS IPSLKEENVV KMDFILSILP AIRQPQLYEL CGSTMNLIFD
     LSVPYASAVI DSLLNISNIG NQCPPLRALN SNISRGFTCS VGEVLNMDTS DVPRCLHCPA
     GTYVATGQNV CTNCPRGYYQ NRDRQGTCMR CPAGTYTKEE GSKSLNDCIP VCGYGTYSPT
     GLVPCLECPR NSFTSDPPTG GFKDCQACPQ NTFTFQPAAS TKSLCRQKCP PGTYSTTGLA
     PCSPCPMNFY QSAIGAQTCN ECPTNMRTEA PGAKGREECK PVVCGEGACQ HGGLCVPMGH
     GIQCFCPAGF SGKRCEIDID ECASQPCYNG GSCVDQPQGY RCECPPGYSG INCQEEASDC
     REDTCPTRAM CKNEPGYKNY TCLCRSGYTG ENCDVTIDPC TANGNPCSNG ASCRALQQGR
     YKCECLPGWE GFHCEANIND CAENPCLLGA NCTDLVNDFQ CTCPPGFTGK RCEEKIDLCL
     SEPCKHGTCV DRLFDHECVC HPGWTGPACD VNIDDCEDRP CANDGVCIDL VNGYSCNCEP
     GYTGKNCQHT IDDCESNPCQ NGATCVDQLD GFVCKCRPGF VGLNCEAEID ECLSDPCNPV
     GTERCLDLDN KFKCACRDGF TGELCETDID DCESNPCLNY GKCTDRVGGF DCECEKGWSG
     LHCEHQITTC DTQSPCQNDA KCIDLFQDYF CVCPSGTDGK NCETAPERCI GNPCMHGGKC
     QDFGSGLNCT CPMDYSGIGC QYEFDACEAH LCQNGATCID VGEGYTCVCP QGFTGVNCEE
     DIVDCKDNSC PPGATCIDLT NGFYCQCPFN MTGDDCRKTI QVDYDLYFSD ATRSTAAQVV
     PFYTGEATSL TIAMWVQFSQ KDDTGIFFTL YGVESPNMAS NRRLMLQAHS SGVQVSLFAD
     YQDVFLSFGE YTSVNDGQWH HVAIVWDGMS GQLQLITEGL IASKIEYAQG RTLPPYLWSV
     LGRPQPDDSK YALSYSESGF QGTMTKVQVW ARALDTTSEI QKQVRDCRSE PVLYNGLILN
     WSGYEITVGG VERNVPSMCG QRRCPNGYTG PNCQQLEVDK EPPVVEHCPG DLWVIAKNGS
     AVVSWDEPHF SDNIGVTKIV ERNGHRPGTT LLWGSYDITY IASDAAGNTA TCSFKVSLLT
     DFCPPLADPV GGVQVCKDWG TGGQFKVCEI SCNPGLRFSE EVPEFYTCGA EGFWRPTPDP
     SMPLVYPACS PSKLAQRVFR IKMLFPSDVL CNKAGQGVLR QKVTSSVNSL NRDWNFCSYS
     VEGSRECKDI QIDVKCDHYR GTQSNRVRRQ AKDGGVYVLE AEIPVLNDPV VHTSTGERST
     VKALLEKLIL EDDQFAVQDI LPNTVPDPAS LELGSEYACP VGQVVMIPDC VPCAIGTFYD
     TRNNTCVPCE RGTYQSEAGQ LQCSKCPIIA GRPGVTAGPG ARSAASCKER CPAGKYFDSE
     TGLCRSCGHG FFQPNEGSFS CELCGLGQTT RSAEATSRKE CRDECSSGQQ LGVDGRCEPC
     PRGTYRAQGV QPSCAACPLG RTTPKVGAKS VEECTLPVCS PGTYLNSTIN MCEECRKGYY
     QPETQQTSCI QCPPNHSTKI TGATSKSECT NPCEQVAEGR PHCDPNAYCI LVPETSDFKC
     ECKPGFNGTG MECTDVCDGF CENQGNCVKD LKGTPSCRCV GSFTGPHCAE RSEFAYIAGG
     IAGAVIFIIV IVLLIWMICV RSTKRRDPKK MLSPAIDQTG SQVNFYYGAH TPYAESIAPS
     HHSTYAHYYD DEEDGWEMPN FYNETYMKDD VVYSTGLHGG GKMSTLARSN ASLYGTKDDL
     YDRLKRHAYT GKKEKSDSDS EVQ
//
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