ID A0A1I8MFI3_MUSDO Unreviewed; 2105 AA.
AC A0A1I8MFI3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Afadin isoform X1 {ECO:0000313|RefSeq:XP_005190697.1, ECO:0000313|RefSeq:XP_019894879.1};
GN Name=101892464 {ECO:0000313|EnsemblMetazoa:MDOA004370-PA};
GN Synonyms=LOC101892464 {ECO:0000313|RefSeq:XP_005190697.1,
GN ECO:0000313|RefSeq:XP_019894879.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA004370-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA004370-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA004370-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005190697.1, ECO:0000313|RefSeq:XP_019894879.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005190697.1,
RC ECO:0000313|RefSeq:XP_019894879.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005190697.1; XM_005190640.3.
DR RefSeq; XP_019894879.1; XM_020039320.1.
DR STRING; 7370.A0A1I8MFI3; -.
DR EnsemblMetazoa; MDOA004370-RA; MDOA004370-PA; MDOA004370.
DR GeneID; 101892464; -.
DR KEGG; mde:101892464; -.
DR VEuPathDB; VectorBase:MDOA004370; -.
DR eggNOG; KOG1892; Eukaryota.
DR OrthoDB; 2881454at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005911; C:cell-cell junction; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd15471; Myo5p-like_CBD_afadin; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01782; RA1_Afadin; 1.
DR CDD; cd01781; RA2_Afadin; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR028842; Afadin.
DR InterPro; IPR037977; CBD_Afadin.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10398; AFADIN; 1.
DR PANTHER; PTHR10398:SF2; AFADIN; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 2.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 2.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 41..135
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 245..337
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 677..905
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT DOMAIN 1000..1085
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 148..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1200..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1399..1569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1719..1805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1823..1868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1917..1944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2047..2105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1399..1456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1473..1509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1516..1556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1719..1741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1743..1757
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1823..1854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2066..2105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2105 AA; 233801 MW; A4FA861B38EDCD8E CRC64;
MSHDTNKKML DREAVRSVIQ QWNANRLDLF ALSEPDENLL FHGVMRFYFQ DAGQKVATKC
IRVASDATVI DVIDTLIEKF RPDMRMLSVP NYALYEVHAN GEERRLNPDE KPLLVQLNWH
IDDREGRFLL KNIDQKTTPI EQNDINFKRK LSKREKKEQK KKEKLAKLNT DGSNTTTNSQ
TNGLNGSHGT DAGETQVAGK LYTELPETSF TRSISNPEAV MRRRRQQKLE KKLQQFRSRD
GGPDTGGTLK IYGESLCQDV PYKTLLLSIR DCAQAVVREM LTKYGLDKAD PLHYCLVQVN
SDGSEYILDD DECPLSILMN HPTSRGSIMF HVRRRPADSQ PRRRKKKPLG AANGANNISQ
DREGPMLVEV THSGDGGRRI KLGSDPIEVG SANTNCLQLF GPSIQARHCL ISLVEGVCTV
TPLHADALTF VNGHHISQPT ILHNGSVVMF GRVASYRFVD SPTDGRYNLA LSQSQLDSAC
LYESRSPASP GSWNDEDGAL SSTHKSDYDA HNPNAGGGNG DHTEIDGKLR TSANGSSDNT
NPSGNGNFSG GGGGGGGDTQ SLEGNLENET KSISSLKSGG SNSQERSPKM PLSSTSAAAH
IEPQGQEPIL PAVLEFPETH QELFLRHIIT ELDVNAPHFK LAPVYSLYLC ARYRASTHYR
PELQPTERAH KLTIFLHHVA NLIYNVVQEQ YTDPRILAFW MANSSEFLHF LKSDRHISAF
SVQAQEVLAE SVQTAFRNLV NCFRVELSQT LNQFLSETID HDSAAGLVLT VLGSAMALLR
RCRVNAALTI QLFSQLFHYI NVICFNTIVA NSHMCTGEWG KVMTERLQLL ELWAERQGLE
LAADCHLAKI NQCAQFLQAP KTSVEEIQQL ACSCFRLNSL QMAALLQQEK IPRNLVDTAI
RMAESVADEL TRADGREVRL EESPELHLAL LLPDDGFSCD VVRGIPSGLV DFLNPLQQQA
MCRLAAQPTS IGLWTVYMHQ FNARSSSAMS NKLPQPEVQV IKLHKNSNGM GLSIVAAKGA
GQDRLGIYIK SVVPGGAADA DGRLQAGDQL LRVDGQSLIG ITQERAADYL VRTGPVVTLD
VAKQGAIYHG LATLLQQPSP VIQRGNRRMS ERDLTRMGAD GKNAGGPLIA NNHLANSKSV
PALHHHMGSG TISMANSKSR STHSLANPAT NLNNTLNNNN TNNNNEQGFY QNLSVYRNQN
QNQSQPILSE RPPMPSHSAM NAYNGNSQQN TQNPILSPTN GTGPTGNQHP NHPYQQQQQQ
QHPNSQHPMI TSPHTSNMLP SRPQSAYYQQ QQQQPSQHQH LSQQQQFAQH GHNFSASTTN
LSTMQHQTQQ QQQQQHSQHP MHHMTAQQQQ LYREQQQQQS MTLGNRSKST QNFQRDMQAQ
QSLRMQQMMA PSMPNISNMY QQQQQHQQQQ QSHPGQHNMS MAASQSMQNV SSMGDALDQN
NGGYLSQAQH SPAGGAQTLR RNMRPDYMDG GAQHSPNMTQ MQQQQQQGNF MTLPPKPGQQ
QQQQLTPPKQ QQPPTAPKPQ QNRLSGTQQQ FPPQSYLGQT LYSQQQQQQQ QQPQSAEEKP
PLPPTTTHPL YKATQQITPG MNYIASTLDP PKGGYVPVSA SALQQNKNLL GTNPWEREER
EKEVEMRREH IRQWREQQIN ELSSIAQRTP QQDEQLKTLI LERDFERRAQ EMEEHEDESE
PSYEKENVQE VFRLNHQQNV IQTPVTNFRQ TEVKIASVVA DQRSNNSNET SPMSSARNSA
AEPIQPPPIP VNPPPSTIPT TIVTGTTTVQ PKSILKNNRY DGSSTAPSSP SKSQKSASFA
DEKHLQTEHP ISSLVRDISH MSITNTNSST SASTTTTTST SSTSYDNNMN MENTSGAPPP
PPPERNSSYL IMSQQKQRSS SIGLLKTATI NSADMQKKSS AASILLNNNN NNIQNNLISS
QQSSPSSSTM DMYSATSSSS PSSILMRDNK RVSFHDEENN YVVGGSVSSY HQMEYNNNSA
MDMMTGNNGA ASDLNTIRED SGFLPQNVDT SMLPSMPATP DTAAWNTTVQ STPGVIGAQE
VYRDPRTRRL AEKQQQQQQR NTEAVPEKLS FKEKMKMFAL ESGEDNTPKD KLKISRAQRD
IDAVH
//
