ID A0A1I8MFP1_MUSDO Unreviewed; 180 AA.
AC A0A1I8MFP1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Adenosine 5'-monophosphoramidase HINT3 {ECO:0000256|ARBA:ARBA00039802};
DE AltName: Full=Histidine triad nucleotide-binding protein 3 {ECO:0000256|ARBA:ARBA00042361};
GN Name=101889070 {ECO:0000313|EnsemblMetazoa:MDOA004418-PA};
GN Synonyms=LOC101889070 {ECO:0000313|RefSeq:XP_005184956.1,
GN ECO:0000313|RefSeq:XP_011293110.1, ECO:0000313|RefSeq:XP_011293111.1,
GN ECO:0000313|RefSeq:XP_011293112.1, ECO:0000313|RefSeq:XP_019892800.1,
GN ECO:0000313|RefSeq:XP_019892801.1, ECO:0000313|RefSeq:XP_019892802.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA004418-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA004418-PA}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA004418-PA};
RX PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G., Giers S.D.,
RA Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M., Meisel R.P.,
RA Minx P., Murphy T.D., Nelson D.R., Reid W.R., Rinkevich F.D.,
RA Robertson H.M., Sackton T.B., Sattelle D.B., Thibaud-Nissen F.,
RA Tomlinson C., van de Zande L., Walden K.K., Wilson R.K., Liu N.;
RT "Genome of the house fly, Musca domestica L., a global vector of diseases
RT with adaptations to a septic environment.";
RL Genome Biol. 15:RESEARCH0466.1-RESEARCH0466.16(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:MDOA004418-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA004418-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005184956.1, ECO:0000313|RefSeq:XP_011293110.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005184956.1,
RC ECO:0000313|RefSeq:XP_011293110.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine 5'-phosphoramidate + H2O = AMP + NH4(+);
CC Xref=Rhea:RHEA:67916, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:57890, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00024472};
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DR RefSeq; XP_005184956.1; XM_005184899.3.
DR RefSeq; XP_011293110.1; XM_011294808.2.
DR RefSeq; XP_011293111.1; XM_011294809.2.
DR RefSeq; XP_011293112.1; XM_011294810.2.
DR RefSeq; XP_019892800.1; XM_020037241.1.
DR RefSeq; XP_019892801.1; XM_020037242.1.
DR RefSeq; XP_019892802.1; XM_020037243.1.
DR STRING; 7370.A0A1I8MFP1; -.
DR EnsemblMetazoa; MDOA004418-RA; MDOA004418-PA; MDOA004418.
DR EnsemblMetazoa; MDOA004418-RB; MDOA004418-PB; MDOA004418.
DR EnsemblMetazoa; MDOA004418-RC; MDOA004418-PC; MDOA004418.
DR EnsemblMetazoa; MDOA004418-RD; MDOA004418-PD; MDOA004418.
DR EnsemblMetazoa; MDOA004418-RE; MDOA004418-PE; MDOA004418.
DR GeneID; 101889070; -.
DR KEGG; mde:101889070; -.
DR VEuPathDB; VectorBase:MDOA004418; -.
DR eggNOG; KOG4359; Eukaryota.
DR OrthoDB; 2782915at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR001310; Histidine_triad_HIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR12486:SF5; ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3; 1.
DR PANTHER; PTHR12486; APRATAXIN-RELATED; 1.
DR Pfam; PF11969; DcpS_C; 1.
DR PRINTS; PR00332; HISTRIAD.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 49..157
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 140..144
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PIRSR:PIRSR601310-3,
FT ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 142
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR601310-1"
SQ SEQUENCE 180 AA; 20577 MW; 7A2060F3DBB1B594 CRC64;
MKETKKNPKT KQLKKYLCCA VFTLAILLPI ILYKIALAPP PFDPMAPCIF CQIASHTKGA
EIEVETDEYV IFKDIKPAST HHYLAVPKRH VESLKTMTKD DIPLVNDLEK AMKEFFISKG
IDIEDALFGF HMPPCISVHH LHLHGIAPRS AMGFMNSFVF KPHTPWFKLV EDARKYLENK
//
