ID A0A1I8MGN6_MUSDO Unreviewed; 906 AA.
AC A0A1I8MGN6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=dynamin GTPase {ECO:0000256|ARBA:ARBA00011980};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN Name=101894249 {ECO:0000313|EnsemblMetazoa:MDOA004705-PB};
GN Synonyms=LOC101894249 {ECO:0000313|RefSeq:XP_005177383.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA004705-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA004705-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA004705-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005177383.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005177383.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR RefSeq; XP_005177383.1; XM_005177326.3.
DR EnsemblMetazoa; MDOA004705-RB; MDOA004705-PB; MDOA004705.
DR GeneID; 101894249; -.
DR KEGG; mde:101894249; -.
DR VEuPathDB; VectorBase:MDOA004705; -.
DR OrthoDB; 1052588at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR CDD; cd01256; PH_dynamin; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF212; DYNAMIN; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 23..289
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 513..621
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 654..745
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 623..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..641
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..827
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 101136 MW; 7DDE7A09001B842A CRC64;
MDTLIPIVNK LQDAFTQLGV HMQLDLPQIA VVGGQSAGKS SVLENFVGKD FLPRGSGIVT
RRPLILQLIN GITEYGEFLH CKGKKFTSFD EIRKEIEDET DRVTGSNKGI SNIPINLRVY
SPHVLNLTLI DLPGLTKVAI GDQPVDIEQQ IRNMILQFIR KETCLILAVT PANTDLANSD
ALKLAKEVDP QGIRTIGVIT KLDLMDEGTD ARDILENKLL PLRRGYIGVV NRSQKDIEGR
KDIHAALAAE RKFFLSHPSY RHIADRLGTP YLQRVLNQQL TNHIRDTLPG LRDKLQKQML
ALEKDVQEFK HFQPGDTSIK TKAMLQMIQQ LQSDFERTIE GSGSALVNTN ELSGGAKINR
IFHERLRFEI VKMSCDEKEL RREISFAIRN IHGIRVGLFT PDMAFEAIVK RQIAQLKEPV
IKCVDLVVQE LSAVVRLCTD KMSRYPRLRE ETERIITTHI REREQMCKEQ ILLLIDFELA
YMNTNHEDFI GFANAQNKSE NANKTGTRQL GNQVIRKGHM VIQNLGIMKG GSRPYWFVLT
SESISWYKDE DEKEKKFMLP LDGLKLRDIE QGFMSMSRRV TFALFSPDGR NVYKDYKQLE
LSCETVEDVE SWKASFLRAG VYPEKQETQE NGDEEGREQT SVETSTDPQL ERQVETIRNL
VDSYMKIVTK TTRDMVPKAI MMLIINNTKD FINGELLAHL YASGDQAQMM EESAEAASKR
EEMLRMYHAC KDALRIIGDV SMATVSAPLP PPVKNDWLPS GLDNPRLSPP SPGGPRKPAP
SAQPAAGGRG PPPPPASGRP APAIPNRPGG GAPPLPGGRP GGALPPPLLP SRVTGAVGGA
ITQQTGANRY IPESMRGQVN QAVGQAAMNE LSNVFAQRFN RPVPNAPPKL PERPSYYGNT
TNGRPF
//
