ID A0A1I8MH70_MUSDO Unreviewed; 773 AA.
AC A0A1I8MH70;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN Name=101896635 {ECO:0000313|EnsemblMetazoa:MDOA004848-PA};
GN Synonyms=LOC101896635 {ECO:0000313|RefSeq:XP_005181328.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA004848-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA004848-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA004848-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005181328.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005181328.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
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DR RefSeq; XP_005181328.1; XM_005181271.2.
DR STRING; 7370.A0A1I8MH70; -.
DR EnsemblMetazoa; MDOA004848-RA; MDOA004848-PA; MDOA004848.
DR VEuPathDB; VectorBase:MDOA004848; -.
DR eggNOG; KOG1311; Eukaryota.
DR OrthoDB; 5480099at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR22883:SF43; PALMITOYLTRANSFERASE APP; 1.
DR PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU079119}; Membrane {ECO:0000256|RuleBase:RU079119};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 43..62
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 74..91
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 190..215
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 235..257
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 144..269
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 424..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..447
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 84106 MW; 7B8AEDF490AF69FE CRC64;
MNLFCCCCCN MAPNTRVTRK WELFAGRNKF YCDGLLMSAP HTGVFYLTCI LITGTSALFF
AFDCPFLATR INPIIPIVGA ILYFFTMSSL LRTTFTDPGV IPRASYDEAA YIEKQIEVPN
SLNSPTYRPP PRTKEVLVKG QTVKLKYCFT CKIFRPPRAS HCSLCDNCVD RFDHHCPWVG
NCVGKRNYRF FYLFLVSLAF LAVFIFSCSV THLVLLMKTE QEVFEVIKKA PFTVIVVFIC
FFSIWSVIGL AGFHTYLTTS DQTTNEDLKG SFSSKGGQRN LNPYSRGNIC LNCCHILCGP
MTPSLIDRRG IATDEYILQM QQHSSPRHPL SDVISATHVS SGAMITSQPM IGGAGGGISI
GGGDLKSRYY DESNTSSSAM EAGSAATAGG VYRPRSYDNL QNGNSNSLAH LVDNEIPLSQ
MDVPAAPHHH SQTHLQQSRR FRHHKQQRNH LDSSGDELDD LELGNANGLM PGSNENLDDD
DVVVVGTTEV VAAVSAIAAT NKARERHNLS DSYNNLFNGD FESPLSNEAT PANSPLSEMP
NLTSAGSGAN LLAAAIMGVA TTHSGNGTLP KSISQSENMY SNIPPVAVAN GKGETPQDNN
IHVYSNLIDE HQHQHNNNKI NTPSAMPPTP TSHGAHNPLD LSSTLMCDDL DLDDPVSIMI
QHPPKSMGEK RNFNFSTNVP DVLSSTTATS TPKSLIASSS ATDNVKLQKM SANELSSSRL
RMLHDTTMID TALDLDSLDD ASLANTSQSC LVKTQQNSPS PPAASASNMG FKV
//
