ID   A0A1I8MI94_MUSDO        Unreviewed;       375 AA.
AC   A0A1I8MI94;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Uncharacterized protein LOC101891785 {ECO:0000313|RefSeq:XP_005175357.1};
GN   Name=101891785 {ECO:0000313|EnsemblMetazoa:MDOA005163-PA};
GN   Synonyms=LOC101891785 {ECO:0000313|RefSeq:XP_005175357.1};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA005163-PA};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA005163-PA}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA005163-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_005175357.1}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|RefSeq:XP_005175357.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   RefSeq; XP_005175357.1; XM_005175300.1.
DR   STRING; 7370.A0A1I8MI94; -.
DR   EnsemblMetazoa; MDOA005163-RA; MDOA005163-PA; MDOA005163.
DR   VEuPathDB; VectorBase:MDOA005163; -.
DR   eggNOG; KOG4294; Eukaryota.
DR   OrthoDB; 3076593at2759; -.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   Proteomes; UP000694905; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF179; PICKPOCKET 10; 1.
DR   Pfam; PF00858; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        346..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   375 AA;  44370 MW;  3133A956BC867C6B CRC64;
     SHYITGKNQD DLWDLLEHLA NSTYMNFDDI PNHSSLERTL DKLQLKPNKY MELIYNLTVD
     HTLNPVDKLR IRCIDNDEYI HSRQVLTEYG LCYLTNNNID DRYSSKYLLF GEMPEPNEYE
     IKHNVRRIQT GSYPDKYIDF NFIGFQSPID VYAHSSYEVM KVDNNYGYTT ENLYYEPFSP
     EITTDHNFET GASVRQRNCR FSHESNLTHF PVYTKNLCLQ ECRLNLVYKV CKCIPHFYPN
     RLRNPKPVCD YKTLRECMPQ HESYFLKLYR ERPNSNKLDM APCYCEQNCV GSVLSLKVSL
     YTRSKQLYGS YGATMTEKEW PTVRYKREIY LTFTDLMVNI GGSAGFFLGF SVLGAIEIFY
     FFTMRLLFHL FGYKL
//