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Database: UniProt
Entry: A0A1I8MKE3_MUSDO
LinkDB: A0A1I8MKE3_MUSDO
Original site: A0A1I8MKE3_MUSDO 
ID   A0A1I8MKE3_MUSDO        Unreviewed;       626 AA.
AC   A0A1I8MKE3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   05-DEC-2018, entry version 14.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   Name=101899571 {ECO:0000313|VectorBase:MDOA005843-PA};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA005843-PA};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA005843-PA}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA005843-PA};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA005843-PA}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA005843-PA};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   RefSeq; XP_005177839.1; XM_005177782.3.
DR   GeneID; 101899571; -.
DR   VectorBase; MDOA005843-RA; MDOA005843-PA; MDOA005843.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 2.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301}.
FT   DOMAIN       16    337       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      528    600       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
FT   ACT_SITE    165    165       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
FT   ACT_SITE    246    246       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
SQ   SEQUENCE   626 AA;  71748 MW;  3C170AE10D36339B CRC64;
     MNVIKPSFTV DHKENTFLLD GKPFQYISGS FHYFRAHPRA WQKRLRTMKA AGLNAIETYV
     EWSLHNPHDG EYVWTDIANV ERFIELAQAE GFYIILRPGP FICAERDNGG LPHWLFTKYP
     GIQMRTNDAN YTHEVSVWYS KLMPRIQRFL YGNGGPIIMV QVENEYGAFY ACDHDYLNWL
     RDETRKYVKD NALLFTTDIP NDRIQCGKIE GVFATIDFGF DRVNEIDNLW KILRSVQPTG
     PLVNSEFYPG WLTHWQEENQ RRDPKSVAEG FRKLLEYKAN VNFYMFFGGT NFGFTAGAND
     FGDSKYTPDI TSYDYDAVMD EMGNVTKKFE LIREVIRDFR EVPKIEIVPE KSFAYGRVEM
     APVMNLLSQE ARAILAKGKA RSSLKPMTFE ELDQYSGLIL YETSLQGIIA GETYVLTLND
     LRDRALVYVD QQFKGILSRQ NANFSITLND LHDSKLQLLV ENQGRINFNI ANDTKGILGA
     ITLQPLNADK VTILNDWLNT AFPLEEPQVT DILTGVQNNS LSFMEDDTTA SLHRGPVIYY
     GEFVVTEEHH TYLNPSGWGK GVAFVNGFNI GRYWPLAGPQ ITLYVPQEIL HKGRNSLVLL
     EYEQTNRKEP GTNPHITLDD KAQLDG
//
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