ID A0A1I8ML51_MUSDO Unreviewed; 251 AA.
AC A0A1I8ML51;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Ribosomal RNA small subunit methyltransferase NEP1 {ECO:0000313|RefSeq:XP_005177296.1};
GN Name=101895994 {ECO:0000313|EnsemblMetazoa:MDOA006079-PA};
GN Synonyms=LOC101895994 {ECO:0000313|RefSeq:XP_005177296.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA006079-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA006079-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA006079-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005177296.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005177296.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase NEP1 family.
CC {ECO:0000256|ARBA:ARBA00008115}.
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DR RefSeq; XP_005177296.1; XM_005177239.3.
DR STRING; 7370.A0A1I8ML51; -.
DR EnsemblMetazoa; MDOA006079-RA; MDOA006079-PA; MDOA006079.
DR GeneID; 101895994; -.
DR KEGG; mde:101895994; -.
DR VEuPathDB; VectorBase:MDOA006079; -.
DR eggNOG; KOG3073; Eukaryota.
DR OrthoDB; 275493at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0070037; F:rRNA (pseudouridine) methyltransferase activity; IEA:InterPro.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0070475; P:rRNA base methylation; IEA:InterPro.
DR CDD; cd18088; Nep1-like; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR005304; Rbsml_bgen_MeTrfase_EMG1/NEP1.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR12636; NEP1/MRA1; 1.
DR PANTHER; PTHR12636:SF5; RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1; 1.
DR Pfam; PF03587; EMG1; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|RefSeq:XP_005177296.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW rRNA-binding {ECO:0000256|ARBA:ARBA00022730};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 251 AA; 28369 MW; E18732E475DEA441 CRC64;
MGGQGKVIRK KRKFQGHKED DPEFDLAKKH LKTSHVRSME KRLIIVLESA QLETVKVGNT
FELLNCDDHA NIMRKNNRDP GSCRPDITHQ CLLMLFDSPL NRAGLLQVYI RTEKNVLIEI
NPQTRIPRTF KRFAGLMVQL LHKFSVRAND TSTKLMKVIK NPITDHLPVG CKKYAMSFSG
KLLSNIRDIV PKKNEEGEEE EPIVLVVGAF AHGVLKSDYT EGLFSFSNYP LSGAIACCKL
CSAFEEVWGI V
//
